Overview of Workplace Exposure to Nanomaterials

Dolez, Patricia I.; Debia, Maximilien

doi:10.1016/b978-0-444-62747-6.00014-2

Cited by 7 publications

(8 citation statements)

References 139 publications

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“…It has been reported that the main route of exposure to CeO 2 -NPs is through inhalation, e.g., during occupational exposure when manufacturing CeO 2 -NP-based products [ 31 , 32 ]. Thus, the lung is the main target organ for toxic effects after airborne CeO 2 -NPs [ 31 , 32 , 33 , 34 , 35 ] exposure.…”

Section: Introductionmentioning

confidence: 99%

A Complete In Vitro Toxicological Assessment of the Biological Effects of Cerium Oxide Nanoparticles: From Acute Toxicity to Multi-Dose Subchronic Cytotoxicity Study

et al. 2021

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Engineered nanomaterials (ENMs) are of significant relevance due to their unique properties, which have been exploited for widespread applications. Cerium oxide nanoparticles (CeO2-NPs) are one of most exploited ENM in the industry due to their excellent catalytic and multi-enzyme mimetic properties. Thus, the toxicological effects of these ENMs should be further studied. In this study, the acute and subchronic toxicity of CeO2-NPs were assessed. First, an in vitro multi-dose short-term (24 h) toxicological assessment was performed in three different cell lines: A549 and Calu3 were used to represented lung tissue and 3T3 was used as an interstitial tissue model. After that, a sub-chronic toxicity assessment (90 days) of these NPs was carried out on a realistic and well-established reconstituted primary human airway epithelial model (MucilAir™), cultured at the Air–Liquid Interface (ALI), to study the long-term effects of these particles. Results showed minor toxicity of CeO2-NPs in acute exposures. However, in subchronic exposures, cytotoxic and inflammatory responses were observed in the human airway epithelial model after 60 days of exposure to CeO2-NPs. These results suggest that acute toxicity approaches may underestimate the toxicological effect of some ENMs, highlighting the need for subchronic toxicological studies in order to accurately assess the toxicity of ENM and their cumulative effects in organisms.

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Section: Introductionmentioning

confidence: 99%

A Complete In Vitro Toxicological Assessment of the Biological Effects of Cerium Oxide Nanoparticles: From Acute Toxicity to Multi-Dose Subchronic Cytotoxicity Study

et al. 2021

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“…The physical, chemical, and biological properties of nanoscale materials are significantly, different from those of bulk materials and single atoms or molecules; therefore, different properties of active pharmaceutical ingredients have been modified in such a way [ 14 , 28 , 29 , 30 , 31 , 32 , 33 ]. In biomedical branches, NPs can be used for nanodiagnostics, as nanomaterials for tissue engineering, as drug carriers for specific delivery/targeted biodistribution or controlled release, and as agents/drugs for prevention/treatment of diseases.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, smaller amounts of substances can be used, which allows decreasing dose-dependent toxicity and various side effects. In addition, many formulations also protect bioactive molecules from degradation [ 19 , 20 , 24 , 25 , 28 , 29 , 31 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ]. The enhancement of bioavailability could be achieved by the improved solubility of bioactive compounds under gastrointestinal (GI) conditions, their protection from the chemical conditions in the GI tract, and controlled release within the GI tract, or by an improved transfer through the intestinal wall, and the particle size, surface properties, and physical state of the nanomaterials used in food supplements are crucial characteristics affecting their final nutritional value [ 43 ].…”

Section: Introductionmentioning

confidence: 99%

Potential of Nanomaterial Applications in Dietary Supplements and Foods for Special Medical Purposes

2019

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Dietary supplements and foods for special medical purposes are special medical products classified according to the legal basis. They are regulated, for example, by the European Food Safety Authority and the U.S. Food and Drug Administration, as well as by various national regulations issued most frequently by the Ministry of Health and/or the Ministry of Agriculture of particular countries around the world. They constitute a concentrated source of vitamins, minerals, polyunsaturated fatty acids and antioxidants or other compounds with a nutritional or physiological effect contained in the food/feed, alone or in combination, intended for direct consumption in small measured amounts. As nanotechnology provides “a new dimension” accompanied with new or modified properties conferred to many current materials, it is widely used for the production of a new generation of drug formulations, and it is also used in the food industry and even in various types of nutritional supplements. These nanoformulations of supplements are being prepared especially with the purpose to improve bioavailability, protect active ingredients against degradation, or reduce side effects. This contribution comprehensively summarizes the current state of the research focused on nanoformulated human and veterinary dietary supplements, nutraceuticals, and functional foods for special medical purposes, their particular applications in various food products and drinks as well as the most important related guidelines, regulations and directives.

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“…The development and exponential growth of nanotechnology-based industries, with an estimation of 6 million workers in 2020 (Roco, 2011), has raised concerns in the potential health risks of exposure to engineered (ENP) or airborne nanoparticles (ANP) (Woskie, 2010). Indeed, over the last years, NP have been regarded as emerging occupational hazards (Dolez and Debia, 2015).…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle exposure and hazard in the ceramic industry: an overview of potential sources, toxicity and health effects

Bessa

Brandão

Viana

et al. 2020

Environmental Research

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The ceramic industry is an industrial sector of great impact in the global economy that has been benefitting from advances in materials and processing technologies. Ceramic manufacturing has a strong potential for airborne particle formation and emission, namely of ultrafine particles (UFP) and nanoparticles (NP), meaning that workers of those industries are risk of potential exposure to these particles. At present, little is known on the impact of engineered nanoparticles (ENP) on the environment and human health and no established Occupational Exposure Limits (OEL) or specific regulations to airborne nanoparticles (ANP) exposure exist raising concerns about the possible consequences of such exposure. In this paper, we provide an overview of the current knowledge on occupational exposure to NP in the ceramic industry and their impact on human health. Possible sources and exposure scenarios, a summary of the existing methods for evaluation and monitoring of ANP in the workplace environment and proposed Nano Reference Values (NRV) for different classes of NP are presented. Case studies on occupational exposure to ANP generated at different stages of the ceramic manufacturing process are described. Finally, the toxicological potential of intentional and unintentional ANP that have been identified in the ceramic industry workplace environment is discussed based on the existing evidence from in vitro and in vivo inhalation toxicity studies.

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Overview of Workplace Exposure to Nanomaterials

Cited by 7 publications

References 139 publications

A Complete In Vitro Toxicological Assessment of the Biological Effects of Cerium Oxide Nanoparticles: From Acute Toxicity to Multi-Dose Subchronic Cytotoxicity Study

A Complete In Vitro Toxicological Assessment of the Biological Effects of Cerium Oxide Nanoparticles: From Acute Toxicity to Multi-Dose Subchronic Cytotoxicity Study

Potential of Nanomaterial Applications in Dietary Supplements and Foods for Special Medical Purposes

Nanoparticle exposure and hazard in the ceramic industry: an overview of potential sources, toxicity and health effects

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