Overview of VI-RADS in Bladder Cancer

Pecoraro, Martina; Takeuchi, Mitsuru; Vargas, Hebert Alberto; Muglia, Valdair Francisco; Cipollari, Stefano; Catalano, Carlo; Panebianco, Valeria

doi:10.2214/ajr.20.22763

Cited by 64 publications

(52 citation statements)

References 88 publications

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“…NMIBC is commonly diagnosed and treated with transurethral resection of bladder tumor (TURBT) and/or intravesical therapy [3,29,30]. NMIBC is considered a stage precursor to MIBC, if undetected or left untreated [31]. MIBC (≥T2 disease) may be treated with partial or radical cystectomy with pelvic lymph node dissection, neoadjuvant or adjuvant chemotherapy, and radiation.…”

Section: Why Mri For Bladder Cancer?mentioning

confidence: 99%

“…A multiparametric MRI (mpMRI) examination consists of anatomic T2-weighted (T2W) images, functional diffusion-weighted images (DWI), and dynamic contrast-enhanced (DCE) images ( Figure 2). Using mpMRI has further improved MRI for BC staging [31].…”

Section: Multiparametric Bladder Mrimentioning

confidence: 99%

“…Multiplanar fast or turbo spin-echo two-dimensional (2D) T2W images should be acquired in at least two planes (axial, sagittal, and/or coronal) with a slice thickness of 3-4 mm to maximize spatial resolution while maintaining an adequate signal-to-noise ratio. These T2W images should be acquired without fat saturation [31,35]. Similar to the recommendations for Prostate Imaging-Reporting and Data System (PI-RADS) version 2.1 used for prostate cancer detection and risk stratification, Vesical Imaging-Reporting and Data System (VI-RADS) recommends that isotropic three-dimensional (3D) T2W images serve as an adjunct [35].…”

Section: Multiparametric Bladder Mrimentioning

confidence: 99%

“…For accurate anatomic localization, the DWI planes and field of view (FOV) should match those used for the T2W and DCE images. An ADC map should be generated with at least two b-value sequences required; the b-values should include a high b-value of 800-1000 s/mm 2 to achieve sufficient contrast resolution compared with surrounding tissues [31,35,37]. There are multiple strategies for accelerating the acquisition of DWI that can be employed, including parallel imaging, increasing the number of excitations, and potentially using the simultaneous multislice (SMS) technique [38].…”

Section: Multiparametric Bladder Mrimentioning

confidence: 99%

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The Role of Imaging in Bladder Cancer Diagnosis and Staging

et al. 2020

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Bladder cancer (BC) is the most common cancer of the urinary tract in the United States. Imaging plays a significant role in the management of patients with BC, including the locoregional staging and evaluation for distant metastatic disease, which cannot be assessed at the time of cystoscopy and biopsy/resection. We aim to review the current role of cross-sectional and molecular imaging modalities for the staging and restaging of BC and the potential advantages and limitations of each imaging modality. CT is the most widely available and frequently utilized imaging modality for BC and demonstrates good performance for the detection of nodal and visceral metastatic disease. MRI offers potential value for the locoregional staging and evaluation of muscular invasion of BC, which is critically important for prognostication and treatment decision-making. FDG-PET/MRI is a novel hybrid imaging modality combining the advantages of both MRI and FDG-PET/CT in a single-setting comprehensive staging examination and may represent the future of BC imaging evaluation.

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Section: Why Mri For Bladder Cancer?mentioning

confidence: 99%

Section: Multiparametric Bladder Mrimentioning

confidence: 99%

Section: Multiparametric Bladder Mrimentioning

confidence: 99%

Section: Multiparametric Bladder Mrimentioning

confidence: 99%

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The Role of Imaging in Bladder Cancer Diagnosis and Staging

et al. 2020

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“…The indications for multiparametric magnetic resonance imaging (mpMRI) for bladder cancer (BCa) are recently expanding and have demonstrated reliable accuracy in staging applications [ 1 , 2 , 3 , 4 , 5 , 6 ]. The Vesical Imaging-Reporting and Data System (VI-RADS) has been introduced to provide preoperative BCa staging and has been prospectively shown to be reliable in assessing the presence of muscle invasion in the pre-TURBT (trans-urethral resection of bladder tumor) setting [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Systematic Review and Meta-Analysis of Vesical Imaging-Reporting and Data System (VI-RADS) Inter-Observer Reliability: An Added Value for Muscle Invasive Bladder Cancer Detection

Giudice

Pecoraro

Vargas

et al. 2020

Cancers

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The Vesical Imaging-Reporting and Data System (VI-RADS) has been introduced to provide preoperative bladder cancer staging and has proved to be reliable in assessing the presence of muscle invasion in the pre-TURBT (trans-urethral resection of bladder tumor). We aimed to assess through a systematic review and meta-analysis the inter-reader variability of VI-RADS criteria for discriminating non-muscle vs. muscle invasive bladder cancer (NMIBC, MIBC). PubMed, Web of Science, Cochrane, and Embase were searched up until 30 July 2020. The Quality Appraisal of Diagnostic Reliability (QAREL) checklist was utilized to assess the quality of included studies and a pooled measure of inter-rater reliability (Cohen’s Kappa [κ] and/or Intraclass correlation coefficients (ICCs)) was calculated. Further sensitivity analysis, subgroup analysis, and meta-regression were conducted to investigate the contribution of moderators to heterogeneity. In total, eight studies between 2018 and 2020, which evaluated a total of 1016 patients via 21 interpreting genitourinary (GU) radiologists, met inclusion criteria and were critically examined. No study was considered to be significantly flawed with publication bias. The pooled weighted mean κ estimate was 0.83 (95%CI: 0.78–0.88). Heterogeneity was present among the studies (Q = 185.92, d.f. = 7, p < 0.001; I2 = 92.7%). Meta-regression analyses showed that the relative % of MIBC diagnosis and cumulative reader’s experience to influence the estimated outcome (Coeff: 0.019, SE: 0.007; p= 0.003 and 0.036, SE: 0.009; p = 0.001). In the present study, we confirm excellent pooled inter-reader agreement of VI-RADS to discriminate NMIBC from MIBC underlying the importance that standardization and reproducibility of VI-RADS may confer to multiparametric magnetic resonance (mpMRI) for preoperative BCa staging.

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Comparison of staging MRI to re‐resection for localised bladder cancer: Narrative review

Klempfner,

Anderson

2024

BJUI Compass

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IntroductionBladder cancer (BCa) is characterised by high prevalence, multifocality, and frequent recurrence, imposing significant clinical and economic burdens. Accurate staging, particularly distinguishing non‐muscle‐invasive bladder cancer (NMIBC) from muscle‐invasive bladder cancer (MIBC) disease, is crucial for guiding treatment decisions. This narrative review explores the potential implications of incorporating multiparametric magnetic resonance imaging (mpMRI) and the Vesical Imaging Reporting Data System (VI‐RADS) into BCa staging, focusing on repeat transurethral resection of bladder tumour (re‐TURBT).MethodsA comprehensive search of PubMed, EMBASE, and MEDLINE databases identified studies published from 2018 to 2023 discussing mpMRI or VI‐RADS in the context of re‐TURBT for BCa staging. Studies meeting inclusion criteria underwent qualitative analysis.ResultsSix recent studies met inclusion criteria. VI‐RADS scoring, accurately predicted muscle invasion, aiding in NMIBC/MIBC differentiation. VI‐RADS scores of ≥3 indicated MIBC with high sensitivity and specificity. VI‐RADS potentially identified patients benefiting from re‐TURBT and those for whom it could be safely omitted.DiscussionmpMRI and VI‐RADS offer promising prospects for BCa staging, potentially correlating more closely with re‐TURBT and radical cystectomy histopathology than initial TURBT. However, validation and careful evaluation of clinical integration are needed. Future research should refine patient selection and optimise mpMRI's role in BCa management.ConclusionVI‐RADS scoring could revolutionise BCa staging, especially regarding re‐TURBT. There is potential that VI‐RADS correlates more with the histopathology of re‐TURBT and radical cystectomy than initial TURBT. While promising, ongoing research is essential to validate utility, refine selection criteria, and address economic considerations. Integration of VI‐RADS into BCa staging holds potential benefits for patients and health care systems.

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Overview of VI-RADS in Bladder Cancer

Cited by 64 publications

References 88 publications

The Role of Imaging in Bladder Cancer Diagnosis and Staging

The Role of Imaging in Bladder Cancer Diagnosis and Staging

Systematic Review and Meta-Analysis of Vesical Imaging-Reporting and Data System (VI-RADS) Inter-Observer Reliability: An Added Value for Muscle Invasive Bladder Cancer Detection

Comparison of staging MRI to re‐resection for localised bladder cancer: Narrative review

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