Overview of the therapeutic strategies for ER positive breast cancer

Blakely, Brianna; Shin, Seobum; Jin, Kideok

doi:10.1016/j.bcp.2023.115552

Cited by 9 publications

(2 citation statements)

References 131 publications

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“…IL-8 has been linked with resistance to certain treatments in breast cancer ( Shi et al, 2012 ). It can promote the survival of cancer cells and protect them from the cytotoxic effects of therapy, thereby contributing to treatment resistance ( Blakely et al, 2023 ). Elevated IL-8 levels have been associated to a worse outcome in breast cancer patients ( Mohammed Bakheet et al, 2024 ).…”

Section: Introductionmentioning

confidence: 99%

Investigating mechanistic insights of curcumin in blocking the Interleukin-8 signaling pathway associated with Breast Cancer: An in-silico approach

Alotaibi,

Hakami,

Hazazi

et al. 2024

Saudi Journal of Biological Sciences

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Section: Introductionmentioning

confidence: 99%

Investigating mechanistic insights of curcumin in blocking the Interleukin-8 signaling pathway associated with Breast Cancer: An in-silico approach

Alotaibi,

Hakami,

Hazazi

et al. 2024

Saudi Journal of Biological Sciences

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“…BC is the most common cancer in women worldwide [ 22 ]. Treatment depends on the expression of the estrogen, progesterone, and/or HER2 receptors [ 23 , 24 ]. It can also be guided by the molecular subtypes basal-like, HER2-positive, and luminal A and B that are based on the tumors’ gene expression patterns [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

High Atlastin 2-2 (ATL2-2) Expression Associates with Worse Prognosis in Estrogen-Receptor-Positive Breast Cancer

Reynisdottir,

Arason,

Freysteinsdottir

et al. 2023

Genes

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The disruption of endoplasmic reticulum (ER) homeostasis occurs in many human diseases. Atlastins (ATLs) maintain the branched network of the ER. The dysregulation of ATL2, located at ER network junctions, has been associated with cancer. ATL2 is necessary for lipid droplet formation in murine breast tissue. Thus, we analyzed whether ATL2 has a role in human breast cancer (BC) pathology. The expression of ATL2 variant ATL2-2 was analyzed in breast tumors from the BC cohorts of the TCGA, METABRIC, and two independent Icelandic cohorts, Cohort 1 and 2; its association with clinical, pathological, survival, and cellular pathways was explored. ATL2-2 mRNA and protein expression were higher in breast tumors than in normal tissue. ATL2-2 mRNA associated with tumor characteristics that indicate a worse prognosis. In METABRIC, high ATL2-2 mRNA levels were associated with shorter BC-specific survival (BCSS) in patients with estrogen-receptor-positive luminal breast tumors, which remained significant after correction for grade and tumor size (HR 1.334, CI 1.063–1.673). Tumors with high ATL2 mRNA showed an upregulation of hallmark pathways MYC targets v1, E2F targets, and G2M checkpoint genes. Taken together, the results suggest that high levels of ATL2-2 may support BC progression through key cancer driver pathways.

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Identification of LRG1 targeting peptide and its application in targeted imaging for breast cancer

Chen,

Zhu,

Zhu

et al. 2023

Nano Res.

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Overview of the therapeutic strategies for ER positive breast cancer

Cited by 9 publications

References 131 publications

Investigating mechanistic insights of curcumin in blocking the Interleukin-8 signaling pathway associated with Breast Cancer: An in-silico approach

Investigating mechanistic insights of curcumin in blocking the Interleukin-8 signaling pathway associated with Breast Cancer: An in-silico approach

High Atlastin 2-2 (ATL2-2) Expression Associates with Worse Prognosis in Estrogen-Receptor-Positive Breast Cancer

Identification of LRG1 targeting peptide and its application in targeted imaging for breast cancer

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