Overview of the Symposium on Public Health Significance of Genomics and Eco-Genetics

Omenn, Gilbert S.

doi:10.1146/annurev.publhealth.012809.103639

Cited by 13 publications

(11 citation statements)

References 28 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…17,18 Family history obtains risk information concerning these shared environmental factors and genetics. 10 One study that explored perceptions of family history found increased perceived risk and worry among those with a family history of diabetes and CVD.…”

Section: Introductionmentioning

confidence: 99%

Perceptions of family history and genetic testing and feasibility of pedigree development among African Americans with hypertension

Pettey

McSweeney

Stewart

et al. 2014

European Journal of Cardiovascular Nursing

View full text Add to dashboard Cite

Background Pedigree development, family history, and genetic testing are thought to be useful in improving outcomes of chronic illnesses such as hypertension (HTN). However, the clinical utility of pedigree development is still unknown. Further, little is known about African Americans’ (AAs’) perceptions of family history and genetic testing. Aims This study examined the feasibility of developing pedigrees for AAs with HTN and explored perceptions of family history and genetic research among AAs with HTN. Methods The US Surgeon General’s My Family Health Portrait was administered, and 30–60 minute in-person individual interviews were conducted. Descriptive statistics were used to analyze pedigree data. Interview transcripts were analyzed with content analysis and constant comparison. Results Twenty-nine AAs with HTN were recruited from one free clinic (15 women, 14 men; mean age 49 years, SD 9.6). Twenty-six (90%) reported their family history in sufficient detail to develop a pedigree. Perceptions of family history included knowledge of HTN in the family, culturally influenced family teaching about HTN, and response to family history of HTN. Most participants agreed to future genetic testing and DNA collection because they wanted to help others; some said they needed more information and others expressed a concern for privacy. Conclusion The majority of AAs in this sample possessed extensive knowledge of HTN within their family and were able to develop a three generation pedigree with assistance. The majority were willing to participate in future genetic research.

show abstract

Section: Introductionmentioning

confidence: 99%

Perceptions of family history and genetic testing and feasibility of pedigree development among African Americans with hypertension

Pettey

McSweeney

Stewart

et al. 2014

European Journal of Cardiovascular Nursing

View full text Add to dashboard Cite

show abstract

“…Why? Because their effects are moderated via gene x gene and gene x environment interactions, whose effects are counted in estimates of broad heritability [114]. High heritability does not imply that specific alleles or combinations of alleles will predict the phenotype.…”

Section: From Evolutionary Medicine To Evolutionary Molecular Medicinementioning

confidence: 99%

Evolutionary molecular medicine

et al. 2012

Self Cite

View full text Add to dashboard Cite

Evolution has long provided a foundation for population genetics, but many major advances in evolutionary biology from the 20th century are only now being applied in molecular medicine. They include the distinction between proximate and evolutionary explanations, kin selection, evolutionary models for cooperation, and new strategies for tracing phylogenies and identifying signals of selection. Recent advances in genomics are further transforming evolutionary biology and creating yet more opportunities for progress at the interface of evolution with genetics, medicine, and public health. This article reviews 15 evolutionary principles and their applications in molecular medicine in hopes that readers will use them and others to speed the development of evolutionary molecular medicine.

show abstract

“…Currently, health promotion programs utilize primary preventative measures such as exercise, diet, weight loss, and stress management [20]. Additionally, clinical indicators and risk factors such as blood pressure, glucose, and lipids are being incorporated into screening, and the potential value of combining these with large-scale genomic and molecular measurements have been discussed [21] but not yet assessed in the context of health promotion. Further, use of these measures is on the 10-year agenda for the United States Department of Health and Human Services Healthy People 2020 health promotion program [22].…”

Section: Introductionmentioning

confidence: 99%

Whole genome sequencing in support of wellness and health maintenance

et al. 2013

View full text Add to dashboard Cite

BackgroundWhole genome sequencing is poised to revolutionize personalized medicine, providing the capacity to classify individuals into risk categories for a wide range of diseases. Here we begin to explore how whole genome sequencing (WGS) might be incorporated alongside traditional clinical evaluation as a part of preventive medicine. The present study illustrates novel approaches for integrating genotypic and clinical information for assessment of generalized health risks and to assist individuals in the promotion of wellness and maintenance of good health.MethodsWhole genome sequences and longitudinal clinical profiles are described for eight middle-aged Caucasian participants (four men and four women) from the Center for Health Discovery and Well Being (CHDWB) at Emory University in Atlanta. We report multivariate genotypic risk assessments derived from common variants reported by genome-wide association studies (GWAS), as well as clinical measures in the domains of immune, metabolic, cardiovascular, musculoskeletal, respiratory, and mental health.ResultsPolygenic risk is assessed for each participant for over 100 diseases and reported relative to baseline population prevalence. Two approaches for combining clinical and genetic profiles for the purposes of health assessment are then presented. First we propose conditioning individual disease risk assessments on observed clinical status for type 2 diabetes, coronary artery disease, hypertriglyceridemia and hypertension, and obesity. An approximate 2:1 ratio of concordance between genetic prediction and observed sub-clinical disease is observed. Subsequently, we show how more holistic combination of genetic, clinical and family history data can be achieved by visualizing risk in eight sub-classes of disease. Having identified where their profiles are broadly concordant or discordant, an individual can focus on individual clinical results or genotypes as they develop personalized health action plans in consultation with a health partner or coach.ConclusionThe CHDWB will facilitate longitudinal evaluation of wellness-focused medical care based on comprehensive self-knowledge of medical risks.

show abstract

Overview of the Symposium on Public Health Significance of Genomics and Eco-Genetics

Cited by 13 publications

References 28 publications

Perceptions of family history and genetic testing and feasibility of pedigree development among African Americans with hypertension

Perceptions of family history and genetic testing and feasibility of pedigree development among African Americans with hypertension

Evolutionary molecular medicine

Whole genome sequencing in support of wellness and health maintenance

Contact Info

Product

Resources

About