Overview of the preparation of organic polymeric nanoparticles for drug delivery based on gelatine, chitosan, poly(d,l-lactide-co-glycolic acid) and polyalkylcyanoacrylate

Lai, Patrick; Daear, Weiam; Löbenberg, Raimar; Prenner, Elmar J.

doi:10.1016/j.colsurfb.2014.03.017

Cited by 153 publications

(93 citation statements)

References 63 publications

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“…NPs were formed immediately upon mixing TPP and CS solutions as molecular linkages between TPPs and CS amino groups. 30,31 The adjustment of parameters such as CS concentration, the CS:TPP polymer ratio, and mixing conditions control CS-TPP NP size. [32][33][34] Initial studies aiming to optimize NP formation were conducted.…”

Section: Preparation Of Cs-tpp Npsmentioning

confidence: 99%

Chitosan–tripolyphosphate nanoparticles as Arrabidaea chica standardized extract carrier: synthesis, characterization, biocompatibility, and antiulcerogenic activity

Servat-Medina¹,

González-Gómez²,

Reyes-Ortega³

et al. 2015

IJN

100

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Natural products using plants have received considerable attention because of their potential to treat various diseases. Arrabidaea chica (Humb. & Bonpl.) B. Verlot is a native tropical American vine with healing properties employed in folk medicine for wound healing, inflammation, and gastrointestinal colic. Applying nanotechnology to plant extracts has revealed an advantageous strategy for herbal drugs considering the numerous features that nanostructured systems offer, including solubility, bioavailability, and pharmacological activity enhancement. The present study reports the preparation and characterization of chitosan–sodium tripolyphosphate nanoparticles (NPs) charged with A. chica standardized extract (AcE). Particle size and zeta potential were measured using a Zetasizer Nano ZS. The NP morphological characteristics were observed using scanning electron microscopy. Our studies indicated that the chitosan/sodium tripolyphosphate mass ratio of 5 and volume ratio of 10 were found to be the best condition to achieve the lowest NP sizes, with an average hydrodynamic diameter of 150±13 nm and a zeta potential of +45±2 mV. Particle size decreased with AcE addition (60±10.2 nm), suggesting an interaction between the extract’s composition and polymers. The NP biocompatibility was evaluated using human skin fibroblasts. AcE-NP demonstrated capability of maintaining cell viability at the lowest concentrations tested, stimulating cell proliferation at higher concentrations. Antiulcerogenic activity of AcE-NP was also evaluated with an acute gastric ulcer experimental model induced by ethanol and indomethacin. NPs loaded with A. chica extract reduced the ulcerative lesion index using lower doses compared with the free extract, suggesting that extract encapsulation in chitosan NPs allowed for a dose reduction for a gastroprotective effect. The AcE encapsulation offers an approach for further application of the A. chica extract that could be considered a potential candidate for ulcer-healing pharmaceutical systems.

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Section: Preparation Of Cs-tpp Npsmentioning

confidence: 99%

Chitosan–tripolyphosphate nanoparticles as Arrabidaea chica standardized extract carrier: synthesis, characterization, biocompatibility, and antiulcerogenic activity

Servat-Medina¹,

González-Gómez²,

Reyes-Ortega³

et al. 2015

IJN

100

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“…The highest encapsulation efficiency was obtained with F6 formulation (89.7%±0.9) which is one of the most critical finding of this research. As indicated by Lai et al 1 (2014) PVA was found the best stabilizer for the second emulsification step for PLGA nanoparticles and increased encapsulation of DS in F5 and F6 formulations.…”

Section: Encapsulation Efficiencymentioning

confidence: 77%

“…Poly(lactic-co-glycolic acid) (PLGA) and poly(ε-caprolactone) (PCL) are two major examples of polyester based polymer family and usually preferred to formulate nanoparticle based drug delivery systems due to their biodegradation to non-toxic and biodegradable monomers. By the approval of United States Food and Drug Administration, 1,2 they have started to used in market and brought immense potential as a drug delivery carrier.…”

Section: Introductionmentioning

confidence: 99%

<i>In Situ</i> Hydrogel Formulation for Intra-Articular Application of Diclofenac Sodium-Loaded Polymeric Nanoparticles

Küçüktürkmen

Öz

Bozkır

2017

tjps

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Objectives: The world's population is getting older and the number of people suffering from arthritis is a major problem according to World Health Organization's data. In this respect, the need for more efficient treatment for arthritis becomes an urgent issue. In this research, nanoparticle bearing in situ gelling hydrogel formulation was developed for prolonged local delivery of diclofenac sodium (DS). Materials and Methods: Emulsion-solvent evaporation technique was used for the preparation of nanoparticles. Particle size, encapsulation efficiency, morphology, and drug release profile of DS loaded biodegradable nanoparticles as well as gel viscosity and gelation time of in situ gelling hydrogel formulations were optimized to increase the time interval between each dose application for enhanced patience compliance. Results:The spherical nanoparticles with a mean particle diameter of 168 nm was obtained and confirmed by both transmission electron microscope and atomic force microscope. Different types of surfactants were tested in the first emulsification step of nanoparticle production process and Arlacel ® -C significantly increased the encapsulation efficiency to 89.7%. Thirty days prolonged in vitro release of DS was achieved by using the combined formulation of polymeric nanoparticles and in situ hydrogel prepared by using poloxomer 407 and chitosan. Conclusion: Local administration of DS with this novel delivery system could be considered of having potential to minimize side effects associated with decreased amount of drug in dosage form compared to conventional oral dose. Key words: Diclofenac sodium, drug delivery, PLGA, Poly(ε-caprolactone), thermosensitive hydrogel, poloxamers ABSTRACT ÖZ Amaç: Dünya Sağlık Örgütü'nün verilerine göre dünya çapında insanların yaş ortalaması ve bağlantılı olarak artrit hastalığından mağdur olan insan sayısı da artmaktadır. Bu açıdan bakıldığında, artrit tedavisi için daha etkili tedavilerin gerekliliği önemli hale gelmiştir. Bu araştırmada, diklofenak sodyumun (DS) uzatılmış lokal taşınımı için nanopartikül içeren in situ hidrojel formülasyonları geliştirilmiştir. Gereç ve Yöntemler: Nanopartiküllerin hazırlanmasında emülsiyon-çözücü buharlaştırma yöntemi kullanılmıştır. DS yüklü nanopartiküllerin partikül büyüklüğü, enkapsülasyon etkinliği, morfolojisi ve ilaç salım profilleri ile in situ hidrojelin jel viskozitesi ve jelleşme süresi, hasta uyuncunu artırmak için her bir dozun uygulanması arasındaki zamanı artırmak amacıyla optimize edilmiştir. Bulgular: Ortalama partikül büyüklüğü 168 nm olan küresel nanopartiküller elde edilmiş ve geçirimli elektron mikroskobu ve atomik kuvvet mikroskobu ile desteklenmiştir. Nanopartikül üretim sürecinin ilk emülsifikasyon adımında farklı sürfaktanlar denenmiş ve Arlacel ® -C diklofenak sodyumun enkapsülasyon etkinliğini %89.7'ye yükseltmiştir. DS'nin 30 güne uzatılmış in vitro salımı, nanopartiküllerin ve poloksamer 407/kitozan ile hazırlanmış in situ hidrojelin kombine kullanılmasıyla başarılmıştır. Sonuç: DS'nin bu yenilikçi taşıy...

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“…They have a lot of applications in chemical process, pharmaceuticals or in food technology industries. Especially, it is particularly interesting for their potential applications as nanocarriers of biological therapeutics [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Zwitterionic drug nanocarriers: A biomimetic strategy for drug delivery

Jin

Chen

Wang

et al. 2014

Colloids and Surfaces B: Biointerfaces

137

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Overview of the preparation of organic polymeric nanoparticles for drug delivery based on gelatine, chitosan, poly(d,l-lactide-co-glycolic acid) and polyalkylcyanoacrylate

Cited by 153 publications

References 63 publications

Chitosan–tripolyphosphate nanoparticles as Arrabidaea chica standardized extract carrier: synthesis, characterization, biocompatibility, and antiulcerogenic activity

Chitosan–tripolyphosphate nanoparticles as Arrabidaea chica standardized extract carrier: synthesis, characterization, biocompatibility, and antiulcerogenic activity

<i>In Situ</i> Hydrogel Formulation for Intra-Articular Application of Diclofenac Sodium-Loaded Polymeric Nanoparticles

Zwitterionic drug nanocarriers: A biomimetic strategy for drug delivery

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Overview of the preparation of organic polymeric nanoparticles for drug delivery based on gelatine, chitosan, poly(d,l-lactide-co-glycolic acid) and polyalkylcyanoacrylate

Cited by 153 publications

References 63 publications

Chitosan&ndash;tripolyphosphate nanoparticles as Arrabidaea chica standardized extract carrier: synthesis, characterization, biocompatibility, and&nbsp;antiulcerogenic activity

Chitosan&ndash;tripolyphosphate nanoparticles as Arrabidaea chica standardized extract carrier: synthesis, characterization, biocompatibility, and&nbsp;antiulcerogenic activity

<i>In Situ</i> Hydrogel Formulation for Intra-Articular Application of Diclofenac Sodium-Loaded Polymeric Nanoparticles

Zwitterionic drug nanocarriers: A biomimetic strategy for drug delivery

Contact Info

Product

Resources

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Chitosan–tripolyphosphate nanoparticles as Arrabidaea chica standardized extract carrier: synthesis, characterization, biocompatibility, and antiulcerogenic activity

Chitosan–tripolyphosphate nanoparticles as Arrabidaea chica standardized extract carrier: synthesis, characterization, biocompatibility, and antiulcerogenic activity