Overview of the Indications and Contraindications for Liver Transplantation

Abstract

Liver transplantation is the only definitive treatment option for patients with irrevocable acute or chronic liver failure. In the last four decades, liver transplantation has developed from an experimental approach with a very high mortality to an almost routine procedure with good short-and long-term survival rates. Here, we present an up-to-date overview of the indications and contraindications for liver transplantation. It is shown how the evaluation of a candidate and finally listing for transplantation has to be performed in a multidisciplinary setting. Meticulous listing, timing, and organ allocation are the crucial factors to achieve an optimal outcome for the individual patient on the one hand, and reasonably using the limited deceased donor pool on the other hand. Living-donor liver transplantation is demanding but necessarily increasing. Because patients after liver transplantation need lifelong aftercare, it is important for primary care clinicians to understand the basic medical problems and risks.

Evolution of Liver Transplantation Program in Shiraz, Iran

“…Liver transplantation (LT) is considered the only standard treatment for these patients (1). The annual rate of LT was estimated to be 3.63 per million inhabitants globally in 2014, which was performed in 107 centers in 5 continents, but most of these centers had less than 100 patients per year (2).…”

Enlarged selection criteria for hepatocellular cancer: is the upper limit needed?

“…LT is the best treatment option not only for early-stage HCC, but for a wide range of pathologies, like chronic and acute hepatitis, or genetically determined metabolic and developmental liver diseases (10). The success of this treatment determines a high demand for grafts, which translates into a chronic organ shortage worldwide.…”

Naujo Donorystės Modelio Reikšmė Potencialių Mirusių Donorų Skaičiui Kauno Donoriniame Centre

“…Esant kepenų ar plaučių terminaliniam nepakankamumui tai gali būti vienintelis gydymo būdas (5)(6)(7). Pagrindinė kliūtis organų transplantacijai -donorinių organų trūkumas (2,4).…”