Overview of the Endocannabinoid System and Endocannabinoidome

Cannabis Science and Therapeutics: An Overview for Clinicians

“…7,11 An expanded view of the ECS that includes the endocannabinoids and related molecules, their biosynthetic and metabolic pathways, and the many receptors with which they interact is termed the endocannabinoidome. 12 The Cannabis Plant and Its Components…”

“…In addition to the CB receptors, endocannabinoids appear to interact with myriad other receptors, including transient receptor potential (TRP) ion channels, peroxisome proliferator‐activated nuclear receptors, and orphan GPCRs 7,11 . An expanded view of the ECS that includes the endocannabinoids and related molecules, their biosynthetic and metabolic pathways, and the many receptors with which they interact is termed the endocannabinoidome 12 …”