Overview of the Diagnosis and Treatment of Stuttering

Maguire, Gerald A.; Yeh, Christopher Y.; Ito, Brandon S.

doi:10.1016/j.jecm.2012.02.001

Cited by 33 publications

(25 citation statements)

References 51 publications

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“…Another possible explanation is the indirect effect of balcofen on the dopamine system. It has been shown that stuttering is related to higher levels of dopamine activity25 and that dopamine antagonists like haloperidol or risperidone can improve stuttering 26. Baclofen will lead to a stimulation of GABA-B receptors , resulting in the inhibition of dopamine release in the surrounding dopaminergic neurons, which in turn may cause an amelioration of stuttering.…”

Section: Discussionmentioning

confidence: 99%

Speaking fluently with baclofen?

Beraha

Bodewits

Brink³

et al. 2017

BMJ Case Reports

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Baclofen is a new and promising pharmacological compound for the treatment of alcohol dependence (AD). Although several randomised trials found a reduction of craving and higher abstinence rates with low and high doses of baclofen, others failed to show positive effects. In this case study, the successful treatment of a patient with AD with daily 120 mg of baclofen is described. In addition to a decrease in alcohol use, we observed the cessation of stuttering during treatment with baclofen, reoccurrence of stuttering following discontinuation, and cessation of stuttering after reinstatement of the treatment. Based on this observation, the direct effects of baclofen on muscle relaxation and anxiety reduction and its indirect effect on dopaminergic inhibition, we believe that baclofen might be a new treatment for stuttering. Further research into the effect of baclofen on stuttering is warranted.

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Section: Discussionmentioning

confidence: 99%

Speaking fluently with baclofen?

Beraha

Bodewits

Brink³

et al. 2017

BMJ Case Reports

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“…Stutterers are likely to exhibit a hypometabolism of the striatum and increased dopamine activity 1,24. Overactivity in the area of the basal ganglia in PDS has been reported in several studies, suggesting that the dopaminergic system plays an important role in the development of stuttering 25,26.…”

Section: Discussionmentioning

confidence: 99%

“…Coexisting symptoms may include facial grimacing and tremors of the muscles involved in speech 1. Stuttering affects approximately 5% of children and 1% of the adult population 1. Most stuttering undergoes spontaneous recovery 1.…”

Section: Introductionmentioning

confidence: 99%

Anterior capsulotomy improves persistent developmental stuttering with a psychiatric disorder: a case report and literature review

Zhang¹,

Peng²,

Zhang³

et al. 2014

NDT

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Stuttering is characterized by disrupted fluency of verbal expression, and occurs mostly in children. Persistent developmental stuttering (PDS) may occur in adults. Reports of the surgical management of PDS are limited. Here we present the case of a 28-year-old man who had had PDS since the age of 7 years, was diagnosed with depression and anxiety disorder at the age of 24 years, and had physical concomitants. He underwent a bilateral anterior capsulotomy 4 years after the diagnosis. Over one year of follow-up, his physical concomitants resolved, and significant improvements in his psychiatric disorders and PDS were observed. To the best of our knowledge, this is the first report of simultaneous improvement in a patient’s PDS and psychiatric disorder after a bilateral anterior capsulotomy.

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“…“The smaller polarity of affected males versus females near the time of onset as compared with the polarity at more advanced ages suggests that recovery from stuttering is considerably more frequent in girls than in boys” [1]. Recovery from developmental stuttering without any intervention occurs in about 75% of persons [2]. Acquired stuttering which can occur at any age is resulted from secondary causes such as drugs, head trauma, stroke, and brain tumors [2-4].…”

Section: Introductionmentioning

confidence: 99%

“…Recovery from developmental stuttering without any intervention occurs in about 75% of persons [2]. Acquired stuttering which can occur at any age is resulted from secondary causes such as drugs, head trauma, stroke, and brain tumors [2-4]. Most published reports of drug induced stuttering have noted psychotropics such as bupropion [5], clozapine [6,7], topiramate [8], lithium [4], tricyclic antidepressants [5,9], phenothiazines [5,9,10], selective serotonin reuptake inhibitors (sertraline and fluoxetine) [5,9], risperidone [11], olanzapine [7], stimulants [9,10,12] as responsible agents.…”

Section: Introductionmentioning

confidence: 99%

Memantine-induced speech problems in two patients with autistic disorder

et al. 2013

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Stuttering is a complex speech disorder. There are two forms of stuttering: developmental stuttering and acquired stuttering. Developmental stuttering is a disorder of early childhood but acquired stuttering can develop at any age. Some medications can induce or deteriorate stuttering as an adverse effect. There are several reports of stuttering due to psychotropic drugs. Memantine, a glutamate antagonist used in the treatment of Alzheimer’s disease, has also been studied for the treatment of autism spectrum disorders. This report presents deterioration of stuttering and speech problem in two children with autistic disorder who were receiving memantine. Based on our knowledge, this is the first time these adverse drug reactions have been attributed to memantine. In conclusion clinicians should consider that speech problems including stuttering may be due to the consumption of memantine, especially, in children may be a side effect of memantine especially in children.

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Overview of the Diagnosis and Treatment of Stuttering

Cited by 33 publications

References 51 publications

Speaking fluently with baclofen?

Speaking fluently with baclofen?

Anterior capsulotomy improves persistent developmental stuttering with a psychiatric disorder: a case report and literature review

Memantine-induced speech problems in two patients with autistic disorder

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