Overview of telepathology, virtual microscopy, and whole slide imaging: prospects for the future

Weinstein, Ronald S.; Graham, Anna R.; Richter, Lynne; Barker, Gail; Krupiński, Elizabeth A.; Lopez, Ana Maria; Erps, Kristine A.; Bhattacharyya, Achyut K.; Yagi, Yukako; Gilbertson, John R.

doi:10.1016/j.humpath.2009.04.006

Cited by 341 publications

(257 citation statements)

References 40 publications

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“…Virtual microscopy, also known as digital slide technology (DST) or whole slide imaging, is a way of creating dynamic images from glass slide specimens, which are viewed and manipulated by using computer-based technology, closely mimicking traditional light microscopy (12,13,18). While examining the virtual slides, the user can change the field of view by panning in the x-y axis and zooming from one magnification to another, just as viewing a glass slide with a traditional optical microscope.…”

Section: Discussionmentioning

confidence: 99%

Transition to virtual microscopy in medical undergraduate pathology education: first experience of turkey in dokuz eylül university hospital

Sağol¹,

Yörükoğlu²,

Lebe³

et al. 2015

TJPATH

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Objective: Pathology education includes an important visual part supporting a wide range of theoretical knowledge. However, the use of traditional microscopes in pathology education has declined over the last decade and there is a lack of interest for microscopy. Virtual microscopy, which was first described in 1985 and has experienced a revolution since 2000, is an alternative technique to conventional microscopy, in which microscopic slides are scanned to form digital images and stored in the web. The aim of this study was to evaluate the use of virtual microscopy in practical pathology sessions and its effects on our students and undergraduate education at our faculty. Material and Method:Second and third year medical students who were used to conventional microscopes were included in the study. The practical sessions were carried out via virtual slides and the effect of the new technique was investigated by a scale at the end of each session. Academic staff from the pathology department joined sessions to promote discussion and respond to questions. Student ratings were analysed statistically. Results:The evaluation of the ratings showed that the students were easily adapted to the use of virtual microscopy. They found it user-friendly and thought that the opportunity of viewing slides at home was advantageous. Collaboration between students and interactive discussions was also improved with this technique. Conclusion:It was concluded that the use of virtual microscopy could contribute to the pathology education of our students.

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Section: Discussionmentioning

confidence: 99%

Transition to virtual microscopy in medical undergraduate pathology education: first experience of turkey in dokuz eylül university hospital

Sağol¹,

Yörükoğlu²,

Lebe³

et al. 2015

TJPATH

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“…[10][11][12] Whole slide imaging has already played an important role in research and education, and undoubtedly will be essential in future pathology practice, such as off-site frozen section interpretation, telepathology consultations, and laboratory quality assurance. [13][14][15][16][17] Even with its stunning success, however, the general adoption of WSI in the pathology community has been slow. It has been proposed that in the future, pathology textbooks and journal articles will incorporate links to WSI, 18 but mainstream journals appear to still be puzzled about or unable to cost justify any potential benefits of adding this capability to the publication.…”

Section: Commentmentioning

confidence: 99%

Educational Value of Digital Whole Slides Accompanying Published Online Pathology Journal Articles: A Multi-Institutional Study

Yin

Han²,

Gibbs³

et al. 2016

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Despite great interest in using whole slide imaging (WSI) in pathology practice and education, few pathology journals have published WSI pertinent to articles within their pages or as supplemental materials.Objective.-To evaluate whether there is measurable added educational value of including WSI in publications.Design.-Thirty-seven participants, 16 (43.3%), 15 (40.5%), and 6 (16.2%) junior pathology residents (postgraduate year 1-2), senior pathology residents (postgraduate year 3-4), and board-certified pathologists, respectively, read a sequence of 10 journal articles on a wide range of pathology topics. A randomized subgroup also reviewed the WSI published with the articles. Both groups completed a survey tool assessing recall of textbased content and of image-based material pertinent to the diseases but not present in the fixed published images.Results.-The group examining WSI had higher performance scores in 72% of image-based questions (36 of 50 questions) as compared with the non-WSI group. As an internal study control, the WSI group had higher performance scores in only 40% of text-based questions (6 of 15 questions). The WSI group had significantly better performance than the non-WSI group for image-based questions compared with text-based questions (P , .05, Fisher exact test).Conclusion.-Our study provides supporting evidence that WSI offers enhanced value to the learner beyond the text and fixed images selected by the author. We strongly encourage more journals to incorporate WSI into their publications.

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“…15,16 Advances in the technology and the high quality of the slides have allowed for a potential reduction of the overall turnaround time required for slide review at the central location. [17][18][19][20] A WSI represents a high-resolution image of the entire glass slide, which is scanned with a high-resolution robotic scanner. The resulting scanned images can be stored on a server for remote viewing using specialized viewing software.…”

Section: Whole Slide Imaging and Its Application In Pathologymentioning

confidence: 99%

Central Pathology Review for Phase III Clinical Trials: The Enabling Effect of Virtual Microscopy

Mróz

Parwani

Kulesza

2013

Archives of Pathology &Amp; Laboratory Medicine

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Context.—Central pathology review (CPR) was initially designed as a quality control measure. The potential of CPR in clinical trials was recognized as early as in the 1960s and quickly became embedded as an integral part of many clinical trials since. Objective.—To review the current experience with CPR in clinical trials, to summarize current developments in virtual microscopy, and to discuss the potential advantages and disadvantages of this technology in the context of CPR. Data Sources.—A PubMed (US National Library of Medicine) search for published studies was conducted, and the relevant articles were reviewed, accompanied by the authors' experience at their practicing institution. Conclusions.—The review of the available literature strongly suggests the growing importance of CPR both in the clinical trial setting as well as in second opinion cases. However, the currently applied approach significantly impedes efficient transfer of slides and patient data. Recent advances in imaging, digital microscopy, and Internet technologies suggest that the CPR process may be dramatically streamlined in the foreseeable future to allow for better diagnosis and quality assurance than ever before. In particular, whole slide imaging may play an important role in this process and result in a substantial reduction of the overall turnaround time required for slide review at the central location. Above all, this new approach may benefit the large clinical trials organized by oncology cooperative groups, since most of those trials involve complicated logistics owing to enrollment of large number of patients at several remotely located participating institutions.

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Overview of telepathology, virtual microscopy, and whole slide imaging: prospects for the future

Cited by 341 publications

References 40 publications

Transition to virtual microscopy in medical undergraduate pathology education: first experience of turkey in dokuz eylül university hospital

Transition to virtual microscopy in medical undergraduate pathology education: first experience of turkey in dokuz eylül university hospital

Educational Value of Digital Whole Slides Accompanying Published Online Pathology Journal Articles: A Multi-Institutional Study

Central Pathology Review for Phase III Clinical Trials: The Enabling Effect of Virtual Microscopy

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