Overview of some recent research developments in fusarium head blight of wheat

Gilbert, J.; Haber, Stephen

doi:10.1080/07060661.2013.772921

Cited by 156 publications

(109 citation statements)

References 170 publications

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“…However, it is not yet fully understood how this specific induction is regulated in the fungus. As there is no single effective control strategy against F. graminearum to date (Gilbert and Haber, 2013), a better understanding of the regulatory mechanisms of toxin production is crucial for the development of improved disease control strategies.…”

Section: Introductionmentioning

confidence: 99%

High-throughput FACS-based mutant screen identifies a gain-of-function allele of the Fusarium graminearum adenylyl cyclase causing deoxynivalenol over-production

Blum

Benfield

Stiller

et al. 2016

Fungal Genetics and Biology

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., High-throughput FACS-based mutant screen identifies a gain-of-function allele of the Fusarium graminearum adenylyl cyclase causing deoxynivalenol over-production, Fungal Genetics and Biology (2016), doi: http://dx.doi. org/10.1016/j.fgb. 2016.02.005 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. ABSTRACTFusarium head blight and crown rot, caused by the fungal plant pathogen Fusarium graminearum, impose a major threat to global wheat production. During the infection, plants are contaminated with mycotoxins such as deoxynivalenol (DON), which can be toxic for humans and animals. In addition, DON is a major virulence factor during wheat infection. However, it is not fully understood how DON production is regulated in F. graminearum. In order to identify regulators of DON production, a high-throughput mutant screen using Fluorescence Activated Cell Sorting (FACS) of a mutagenized TRI5-GFP reporter strain was established and a mutant over-producing DON under repressive conditions identified. A gain-of-function mutation in the F. graminearum adenylyl cyclase (FAC1), which is a known positive regulator of DON production, was identified as the cause of this phenotype through genome sequencing and segregation analysis. Our results show that the high-throughput mutant screening procedure developed here can be applied for identification of fungal proteins involved in diverse processes.

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Section: Introductionmentioning

confidence: 99%

High-throughput FACS-based mutant screen identifies a gain-of-function allele of the Fusarium graminearum adenylyl cyclase causing deoxynivalenol over-production

Blum

Benfield

Stiller

et al. 2016

Fungal Genetics and Biology

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“…Many biological control agents have been tested in foliar applications to wheat, but their efficacy generally has been lower than that of fungicides. Approaches using microorganisms to break down sources of inoculum in wheat and maize fields has shown some promise (Gilbert and Haber, 2013). However, application may be limited to areas with diverse crop production and smaller, isolated maize and wheat fields.…”

Section: Managing Mycotoxins Pre-and Post-harvestmentioning

confidence: 99%

Mycotoxins that affect the North American agri-food sector: state of the art and directions for the future

Miller

Schaafsma

Bhatnagar

et al. 2014

WMJ

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This paper summarises workshop discussions at the 5 th international MYCORED meeting in Ottawa, Canada ( June 2012) with over 200 participants representing academics, government and industry scientists, government officials and farming organisations (present in roughly equal proportions) from 27 countries. Workshops centred on how mycotoxins in food and feed affect value chains and trade in the region covered by the North American Free Trade Agreement. Crops are contaminated by one or more of five important mycotoxins in parts of Canada and the United States every year, and when contaminated food and feed are consumed in amounts above tolerable limits, human and animal health are at risk. Economic loss from such contamination includes reduced crop yield, grain quality, animal productivity and loss of domestic and export markets. A systematic effort by grain producers, primary, transfer, and terminal elevators, millers and food and feed processers is required to manage these contaminants along the value chain. Workshops discussed lessons learned from investments in plant genetics, fungal genomics, toxicology, analytical and sampling science, management strategies along the food and feed value chains and methods to ameliorate the effects of toxins in grain on animal production and on reducing the impact of mycotoxins on population health in developing countries. These discussions were used to develop a set of priorities and recommendations.

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“…The topic of breeding for resistance and transgenic resistance would require a full manuscript. These topics have been specifically and extensively reviewed by several Authors to which the reader is directed [58,59]. Despite progress made in prevention through breeding of resistant varieties and improvement in agronomic practices [31,57], hazardous concentrations of mycotoxins may further occur as a result of annual weather fluctuations.…”

Section: Preharvest Mitigation Measures and Managementmentioning

confidence: 99%

Mycotoxins in Wheat and Mitigation Measures

Cheli¹,

Pinotti²,

Novacco³

et al. 2017

Wheat Improvement, Management and Utilization

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Latest estimates for world cereal production in 2015 and EU-28 production in 2014 are approximately 2540 and 323 mil tons, respectively. The FAO estimated that the global wheat consumption is about 66 kg/per capita. Among the most important risks associated with wheat consumption are mycotoxins. It has been estimated that up to 25% of the world's crops grown for food and feed may be contaminated with mycotoxins. Despite efforts in controlling fungal growth, mycotoxin co-contamination represents an unavoidable risk, occurring pre-and postharvest and resulting in reduced nutritional value and possible risks for human and animal health. In addition to health risks, mycotoxins have a detrimental effect on the quality and the processing performance of wheat. Mitigation measures to manage the challenge of mycotoxins in wheat include strategies at pre-and postharvest. Preharvest events are predominantly dictated by environmental factors and good agronomic/cultural practices, whereas storage and processing are the major areas where contamination can be prevented at postharvest. Integrating as many management options as possible may minimize the risk of mycotoxin contamination in wheat and wheat products.

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Overview of some recent research developments in fusarium head blight of wheat

Cited by 156 publications

References 170 publications

High-throughput FACS-based mutant screen identifies a gain-of-function allele of the Fusarium graminearum adenylyl cyclase causing deoxynivalenol over-production

High-throughput FACS-based mutant screen identifies a gain-of-function allele of the Fusarium graminearum adenylyl cyclase causing deoxynivalenol over-production

Mycotoxins that affect the North American agri-food sector: state of the art and directions for the future

Mycotoxins in Wheat and Mitigation Measures

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