Overview of Solid Lipid Nanoparticles in Breast Cancer Therapy

Abstract

Lipid nanoparticles (LNPs), composed of ionized lipids, helper lipids, and cholesterol, provide general therapeutic effects by facilitating intracellular transport and avoiding endosomal compartments. LNP-based drug delivery has great potential for the development of novel gene therapies and effective vaccines. Solid lipid nanoparticles (SLNs) are derived from physiologically acceptable lipid components and remain robust at body temperature, thereby providing high structural stability and biocompatibility. By enhancing drug delivery through blood vessels, SLNs have been used to improve the efficacy of cancer treatments. Breast cancer, the most common malignancy in women, has a declining mortality rate but remains incurable. Recently, as an anticancer drug delivery system, SLNs have been widely used in breast cancer, improving the therapeutic efficacy of drugs. In this review, we discuss the latest advances of SLNs for breast cancer treatment and their potential in clinical use.

A Systematic Review on Nano Drug Delivery System: Solid Lipid Nanoparticles (Sln)

“…Solid lipid nanoparticles can combine particle shape and physical integrity with both physical and chemical stabilization of delicate components. SLN are nanostructures composed of solid lipids such as glyceryl behenate (Compritol), stearic triglyceride (tristearin), cetyl palmitate, and glycerol tripalmitate (tripalmitin) with sizes ranging between 50 and 1,000 nm [28][29][30].…”

Strategies and Recent Advances on Improving Efficient Antitumor of Lenvatinib Based on Nanoparticle Delivery System

“…43 Because of their unique features, NDDS can increase drug stability, optimize body distribution, prolong circulation time, as well as improve drug targeting to increase efficacy and reduce possible side effects from the free drugs. 43,[57][58][59][60][61][62]…”

A Review of the Effectiveness of Using Nanoparticles in the Treatment and Diagnosis of Breast Cancer

“…Therefore, the need to create a system to deliver drugs to tumor tissue without side effects is felt. [1,4] The utilization of nanoparticles in the electronic, medical industries, and food is expanding. Preparation and creation of nano-sized particles (less than 100 nm) increases their surface area and increases the possibility of their reactions or organic and inorganic molecules.…”