Overview of serpin B9 and its roles in cancer (Review)

Wang, Wenjun; Wang, Jiao; Ouyang, Cheng; Chen, Chong; Xu, Xiaofeng; Ye, Xiaoqun

doi:10.3892/or.2021.8141

Cited by 13 publications

(16 citation statements)

References 104 publications

(131 reference statements)

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“…In general, Sb9 is the only intracellular ovalbumin family serpin that is expressed in certain immune cells. Moreover, it has been reported to function as a vital protector in certain cancer cells, including lung cancer, melanoma, breast cancer, and prostate cancer. ,, Besides, Sb9 is also implicated in tumor apoptosis, carcinogenesis, development, metastasis, drug resistance, and sustaining the stemness of cancer stem cells (CSCs) . Nevertheless, although Sb9 is expressed in OSCC, its role remains unclear …”

Section: Discussionmentioning

confidence: 99%

“…9,40,41 Besides, Sb9 is also implicated in tumor apoptosis, carcinogenesis, development, metastasis, drug resistance, and sustaining the stemness of cancer stem cells (CSCs). 42 Nevertheless, although Sb9 is expressed in OSCC, its role remains unclear. 43 In this study, we observed that Sb9 is widely expressed in OSCC and may modulate the fate of cancer cells.…”

Section: ■ Discussionmentioning

confidence: 99%

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Protocatechuic Acid-Based Supramolecular Hydrogel Targets SerpinB9 to Achieve Local Chemotherapy for OSCC

Cao

Yang

et al. 2022

ACS Appl. Mater. Interfaces

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Protocatechuic acid (PCA) is a natural phenolic acid present in daily vegetables and fruits. Notably, PCA was demonstrated to inhibit the biological function of SerpinB9 (Sb9) and exhibit an excellent antitumor effect, showing great potential in cancer treatment. However, the short half-life time limits PCA's wide application against cancers. To overcome this shortage of PCA, we integrated PCA and another natural product with strong self-assembling properties, isoguanosine (isoG), to develop a novel multifunctional supramolecular hydrogel with good biocompatibility and injectability, which remarkably lengthens the releasing time of PCA and exerts considerable anticancer effects in vitro and in vivo. Besides, we surprisingly found that PCA could not only target Sb9 but also restrain cancer development through activating the JNK/P38 pathway, decreasing the ROS level, and repairing cancer stemness. In all, our results demonstrate that this PCA-based hydrogel could act as a multifunctional hydrogel system equipped with considerable anticancer effects, providing potential local administration integrating with targeted therapy and chemotherapy in one simple modality.

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Section: Discussionmentioning

confidence: 99%

Section: ■ Discussionmentioning

confidence: 99%

Protocatechuic Acid-Based Supramolecular Hydrogel Targets SerpinB9 to Achieve Local Chemotherapy for OSCC

Cao

Yang

et al. 2022

ACS Appl. Mater. Interfaces

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“…The abundance of serine in the body is also related to the occurrence of tumors. 395 For example, study found that serine upregulated in acute myeloid leukemia, 396 as well as primary melanomas. 397 Serine has recently been identified as an allosteric effect factor of M2 isoform of pyruvate kinase (PKM2).…”

Section: Metabolite Sensing and Epigenetic Regulation Of Protein Meta...mentioning

confidence: 99%

Signaling pathways in cancer metabolism: mechanisms and therapeutic targets

You

Xie

Zhang

et al. 2023

Sig Transduct Target Ther

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A wide spectrum of metabolites (mainly, the three major nutrients and their derivatives) can be sensed by specific sensors, then trigger a series of signal transduction pathways and affect the expression levels of genes in epigenetics, which is called metabolite sensing. Life body regulates metabolism, immunity, and inflammation by metabolite sensing, coordinating the pathophysiology of the host to achieve balance with the external environment. Metabolic reprogramming in cancers cause different phenotypic characteristics of cancer cell from normal cell, including cell proliferation, migration, invasion, angiogenesis, etc. Metabolic disorders in cancer cells further create a microenvironment including many kinds of oncometabolites that are conducive to the growth of cancer, thus forming a vicious circle. At the same time, exogenous metabolites can also affect the biological behavior of tumors. Here, we discuss the metabolite sensing mechanisms of the three major nutrients and their derivatives, as well as their abnormalities in the development of various cancers, and discuss the potential therapeutic targets based on metabolite-sensing signaling pathways to prevent the progression of cancer.

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“…Resistance of tumor cells to the cytotoxic effect of cellular and humoral components of the immune system . An example is increased expression of prosurvival proteins allowing prevention of cancer cell destruction: BCL-2 [ 37 ], proteinase inhibitor 9 (PI-9, serpin B9, an inhibitor of granzyme B-mediated apoptosis) [ 38 ] and cellular FLICE inhibiting protein (c-FLIP, CFLAR) [ 39 ].…”

Section: Cancer Immunoediting Hypothesismentioning

confidence: 99%

Cancer immunoediting hypothesis: history, clinical implications and controversies

Lasek¹

2022

cejoi

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The main function of the immune system is to protect against infectious pathogens and to ensure tissue homeostasis. The latter function includes preventing autoimmune reactions, tolerizing cells to nonpathogenic environmental microorganisms, and eliminating apoptotic/damaged, transformed, or neoplastic cells. The process of carcinogenesis and tumor development and the role of the immune system in inhibiting progression of cancer have been the subject of intense research since the end of the 20 th century and resulted in formulation of the cancer immunoediting hypothesis. The hypothesis postulates three steps in oncogenesis: 1) elimination – corresponding to immunosurveillance, 2) equilibrium in which the growth of transformed or neoplastic cells is efficiently controlled by immune effector mechanisms, and 3) escape in which cancer progresses due to an ineffective antitumor response. In parallel, a new field of science – immune-oncology – has arisen. Attempts are also being made to quantify intra-tumoral and peritumoral T cell infiltrations and to define optimal immunological parameters for prognostic/predictive purposes in several types of cancer. The knowledge of relationships between the tumor and the immune system has been and is practically exploited therapeutically in the clinic to treat cancer. Immunotherapy is a standard or supplementary treatment in various types of cancer.

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Overview of serpin B9 and its roles in cancer (Review)

Cited by 13 publications

References 104 publications

Protocatechuic Acid-Based Supramolecular Hydrogel Targets SerpinB9 to Achieve Local Chemotherapy for OSCC

Protocatechuic Acid-Based Supramolecular Hydrogel Targets SerpinB9 to Achieve Local Chemotherapy for OSCC

Signaling pathways in cancer metabolism: mechanisms and therapeutic targets

Cancer immunoediting hypothesis: history, clinical implications and controversies

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