Overview of rotavirus infections in Korea

Seo, Jeong Kee; Sim, Jay G

doi:10.1046/j.1442-200x.2000.01250.x

Cited by 63 publications

(60 citation statements)

References 10 publications

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“…The highest prevalence was found in April (57/134, 42.5%), followed by March (64/184, 34.8%) and May (21/85, 24.7%), respectively. The results of this study are in agreement with previous findings that group A RoVs were detected more frequently in March and April in Japan (24,25).…”

Section: Discussionsupporting

confidence: 93%

Genotypes of rotavirus associated with acute gastroenteritis in Seoul, Korea

Park

Lee

et al. 2011

Microbiology and Immunology

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Acute viral gastroenteritis is one of the most common infectious diseases in infants and young children. Rotavirus is mainly important in childhood. The present study determined the detection rate, seasonality and G and P genotypes of rotaviruses in children hospitalized for acute gastroenteritis in Seoul, Korea in 2009. A total of 1,423 stool specimens were screened by ELISA for the presence of rotavirus antigens and the rotavirus-positive stools genotyped by RT-PCR. The G genotype was determined for 90% of samples (242/269) and the P genotype for 93.3% (251/269). During the study, 25 G-P combinations were detected with G1P[8] in 38.3% (n = 103) and G4P[6] in 5.9% (n = 16) cases. These data provided information on rotavirus in patients with acute gastroenteritis in Seoul, Korea and provided baseline data to motivate for the implementation of control measures for rotavirus disease. Key words gastroenteritis, G and P types, rotavirus.Rotaviruses are recognized as the major etiological agents among infants and young children, and are the leading cause of life-threatening diarrhoeal disease in many countries (1,2,3). The virus is a member of the family Reoviridae and its genome is composed of 11 segments of double-stranded RNA that encode for the six structural proteins that make up the virus particles (viral proteins [VPs]) and six nonstructural proteins (NSPs) (3). The outer capsid is composed of two proteins, glycoprotein VP7 and protease-sensitive VP4 that confer protective immunity (4). Thus, VP7 and VP4 are used to classify RoVs (3). Semi-nested PCR, based on type-specific primers, is used to determine G and P genotypes. As VP7 and VP4 genes can and do segregate independently, a dual typing system is necessary in order to characterize the strains of RoVs co-circulating during different seasons in different locations (4). It is generally accepted that at least 23 G types [4] and 32 P types (5) are known. Among them, G1-4 are common human genotypes, though increase in prevalence of G12 and G9 strains have been reported worldwide (6). Epidemiological studies have shown that four G (G1-G4) and three P (P[4], P [6], and P[8]) are the most frequent VP7 and VP4 types (7). The distribution of different G and P genotypes and RoV strains varies from country and area to area and, therefore, knowledge of the molecular epidemiology of RoVs in circulation is important in the effort to develop a suitable and efficacious vaccine (7). The aims of this study were to investigate the detection rate of RoV infections and the prevalence of the G and P genotypes of RoV strains detected in children hospitalized with acute gastroenteritis in Seoul, Korea in 2009.

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Section: Discussionsupporting

confidence: 93%

Genotypes of rotavirus associated with acute gastroenteritis in Seoul, Korea

Park

Lee

et al. 2011

Microbiology and Immunology

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“…Rotavirus infections occurred almost all year in the south, with less distinct seasonal differences (13,20,23,24). Our results are similar to those of studies conducted in Korea, China, and Thailand but differed from those of a Japanese study, in which rotavirus was rarely detected from September to December (9,20,29,33).…”

Section: Rotavirus Infectionsupporting

confidence: 72%

“…Other studies also showed a low prevalence of rotavirus detection in fecal samples in this group (21,27,31). It was reported that asymptomatic infection with rotavirus was not infrequent, especially in neonates, in whom only mild or subclinical symptoms were seen (17,29). However, most of children infected with rotavirus showed one or several clinical symptoms.…”

Section: Rotavirus Infectionmentioning

confidence: 99%

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Diarrhea Caused by Rotavirus in Children Less than 5 Years of Age in Hanoi, Vietnam

et al. 2004

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Group A rotaviruses are the major cause of diarrhea in young children worldwide. From March 2001 to April 2002, 836 children less than 5 years of age were investigated in Hanoi, Vietnam. This included 587 children with diarrhea and 249 age-matched controls. Group A rotavirus was identified in 46.7% of the children with diarrhea and 3.6% of the controls, which was a significant difference. Within the diarrhea group, the highest prevalence was seen in children from 13 to 24 months of age, and the prevalence was higher in males than in females. The symptoms of acute diarrhea caused by rotavirus were watery diarrhea, vomiting, fever, and dehydration. A higher prevalence of rotavirus detection was obtained for children who had all of these symptoms, followed by those who had diarrhea with vomiting-dehydration, fever-dehydration, and dehydration. The high rates occurred from September to December, although the infection was encountered all year round. In 58 patients (21.2% of the rotavirus-infected children), rotavirus infection was detected in association with either diarrheagenic Escherichia coli or Shigella spp. The most frequent combinations were rotavirus-enteroaggregative E. coli and rotavirus-enteropathogenic E. coli. At least one enteropathogen was identified from about 64% percent of the samples. The bacterial infection may not have given rise to clinical symptoms of such severity. The present study demonstrates the burden of rotavirus diarrhea in Hanoi, Vietnam. Continuous surveillance of diarrhea caused by rotavirus in young children would play an important role in diagnosis, treatment, and prophylaxis in order to improve the health of children in Vietnam.

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“…구조 단백질들 중 VP6은 inner capsid protein으로 rotavirus들이 공통적으로 가지는 항원 결정기이기 때문에 혈청학 적 진단에 사용되며, A~G 혈청군(group)으로 나누는 기준이 된다. 혈청군 중 A, B, C group만 사람과 동물, 모두에게 질병 을 유발하는데, 이 중 group A rotavirus는 세계적으로 가장 높은 분포를 보인다 [3,7,8,24] …”

Section: 서 론unclassified