Overview of role of survivin in cancer: expression, regulation, functions, and its potential as a therapeutic target

Fang, Xian-long; Cao, Xue-ping; Xiao, Jun; Hu, Yun; Chen, Mian; Raza, Hafiz Khuram; Wang, Huai-yuan; He, Xu; Gu, Jin-fa; Zhang, Kang-jian

doi:10.1080/1061186x.2024.2309563

Journal of Drug Targeting

2024

DOI: 10.1080/1061186x.2024.2309563

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Overview of role of survivin in cancer: expression, regulation, functions, and its potential as a therapeutic target

Xian-long Fang,

Xue-ping Cao,

Jun Xiao

et al.

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2024

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Cited by 2 publications

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Assessment of Serum Survivin in Women with Placenta Previa and Accreta Spectrum.

Yilmaz,

Bakirci,

Sahin

et al. 2024

Preprint

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Background Placenta previa and placenta accreta spectrum (PAS) are characterized by irregular placental implantation and invasion, which can lead to significant maternal and fetal morbidity. Survivin is a critical protein that affects cellular longevity and apoptosis, and plays a crucial role in placental development during pregnancy. This study aimed to examine the maternal serum survivin levels in patients with normal placentation, placenta previa, and PAS. Methods In this prospective cross-sectional study, we enrolled 84 pregnant women categorized into the control (n=42), placenta previa (n=24), and PAS (n=28) groups. Serum survivin levels were quantitatively determined using ELISA. Results A significant elevation in serum survivin levels was observed in the placenta previa and PAS groups compared to the controls, suggesting a role for survivin in the pathophysiological response to against abnormal placental adherence and invasion. Conclusions Elevated serum survivin level may serve as an early biomarker for diagnosing and managing placenta previa and PAS, underscoring the need for a multidisciplinary approach to managing these complex pregnancy complications.

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Assessment of Serum Survivin in Women with Placenta Previa and Accreta Spectrum.

Yilmaz,

Bakirci,

Sahin

et al. 2024

Preprint

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Survivin Promotes Lung Cancer Ferroptosis Resistance by Suppressing Mitophagic Degradation of Gpx4

Dong,

Sai,

Shen

et al. 2024

Preprint

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Overview of role of survivin in cancer: expression, regulation, functions, and its potential as a therapeutic target

Cited by 2 publications

References 204 publications

Assessment of Serum Survivin in Women with Placenta Previa and Accreta Spectrum.

Assessment of Serum Survivin in Women with Placenta Previa and Accreta Spectrum.

Survivin Promotes Lung Cancer Ferroptosis Resistance by Suppressing Mitophagic Degradation of Gpx4

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