Overview of recurrent respiratory papillomatosis

Wiatrak, Brian J.

doi:10.1097/00020840-200312000-00005

Cited by 99 publications

(84 citation statements)

References 70 publications

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“…A decrease in cervical dysplasia was noted in approximately 50% of the women given oral I3C, and no significant side effects were observed (28). Both human adults and children have benefited from oral I3C or DIM in the treatment of laryngeal papillomatosis, and I3C and DIM have been reported to be well tolerated in these human studies (29)(30)(31).…”

Section: Introductionmentioning

confidence: 95%

Pilot Study: Effect of 3,3′-Diindolylmethane Supplements on Urinary Hormone Metabolites in Postmenopausal Women With a History of Early-Stage Breast Cancer

Dalessandri¹,

Firestone²,

Fitch³

et al. 2004

Nutrition and Cancer

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Dietary indoles, present in , and cortisol in the first morning urine sample before intervention and 31 days after intervention. Nineteen women completed the study, for a total of 10 in the treatment group and 9 in the placebo group. DIM-treated subjects, relative to placebo, showed a significant increase in levels of 2-OHE 1 (P = 0.020), DIM (P = 0.045), and cortisol (P = 0.039), and a nonsignificant increase of 47% in the 2-OHE 1 /16 α-OHE 1 ratio from 1.46 to 2.14 (P = 0.059). In this pilot study, DIM increased the 2-hydroxylation of estrogen urinary metabolites.

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Section: Introductionmentioning

confidence: 95%

Pilot Study: Effect of 3,3′-Diindolylmethane Supplements on Urinary Hormone Metabolites in Postmenopausal Women With a History of Early-Stage Breast Cancer

Dalessandri¹,

Firestone²,

Fitch³

et al. 2004

Nutrition and Cancer

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“…Several studies have shown that 3,3V -diindolylmethane can inhibit the development of both carcinogen-induced and implanted tumors in rodents (3,4). In addition, 3,3V -diindolylmethane and its precursor indole-3-carbinol (I3C) are considered to be the preferred treatment for recurrent respiratory papillomatosis in humans (5).…”

Section: Introductionmentioning

confidence: 99%

3,3′-Diindolylmethane Is a Novel Mitochondrial H+-ATP Synthase Inhibitor that Can Induce p21Cip1/Waf1 Expression by Induction of Oxidative Stress in Human Breast Cancer Cells

Gong

Sohn²,

Xue³

et al. 2006

Cancer Research

132

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Epidemiologic evidence suggests that high dietary intake of Brassica vegetables, such as broccoli, cabbage, and Brussels sprouts, protects against tumorigenesis in multiple organs. 3,3V -Diindolylmethane, one of the active products derived from Brassica vegetables, is a promising antitumor agent. Previous studies in our laboratory showed that 3,3V -diindolylmethane induced a G 1 cell cycle arrest in human breast cancer MCF-7 cells by a mechanism that included increased expression of p21. In the present study, the upstream events leading to p21 overexpression were further investigated. We show for the first time that 3,3V -diindolylmethane is a strong mitochondrial H + -ATPase inhibitor (IC 50 f20 Mmol/L). 3,3V -Diindolylmethane treatment induced hyperpolarization of mitochondrial inner membrane, decreased cellular ATP level, and significantly stimulated mitochondrial reactive oxygen species (ROS) production. ROS production, in turn, led to the activation of stress-activated pathways involving p38 and c-Jun NH 2 -terminal kinase. Using specific kinase inhibitors (SB203580 and SP600125), we showed the central role of p38 and c-Jun NH 2 -terminal kinase (JNK) pathways in 3,3V -diindolylmethaneinduced p21 mRNA transcription. In addition, antioxidants significantly attenuated 3,3V -diindolylmethane-induced activation of p38 and JNK and induction of p21, indicating that oxidative stress is the major trigger of these events. To further support the role of ROS in 3,3V -diindolylmethane-induced p21 overexpression, we showed that 3,3V -diindolylmethane failed to induce p21 overexpression in mitochondrial respiratory chain deficient R 0 MCF-7 cells, in which 3,3V -diindolylmethane did not stimulate ROS production. Thus, we have established the critical role of enhanced mitochondrial ROS release in 3,3V -diindolylmethane-induced p21 up-regulation in human breast cancer cells. (Cancer Res 2006; 66(9): 4880-7)

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“…Juvenil papillomatozis çok sayıda, küçük bazen birleşen papillomalardan oluşur ve genellikle çocuklarda bazen de yetişkin yaş grubunda görülür. Laringoskopik incelemede papillomlar pembe renkli görülür ve tipik olarak vokal kordları, bant ventrikülleri tutar, diğer tüm laringeal yapılarda, trakeobronşiyal havayolunda da yerleşebilirler (9). Laringeal verruka vulgaris ise genellikle tek, beyaz renkli keratotik lezyonlar olarak görülmekte-dir.…”

Section: Discussionunclassified

Laryngeal Verruca Vulgaris Presenting with Dysphonia: A Case Report

Yıldırım¹,

Tezcaner²,

Fatullayev³

et al. 2017

Turk Arch Otorhinolaryngol

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Verruca vulgaris is a common skin lesion that is associated with human papilloma virus and is observed on the surface of skin. Verruca vulgaris is rarely seen in mucosal membranes. Atypical locations may be confused with verrucous carcinoma. The incidence of laryngeal verruca vulgaris has not yet been reported in the literature. Differential diagnoses in histopathological examinations include keratosis, squamous papilloma, verrucous hyperplasia, and verrucous carcinoma. Distinguishing disease from verrucous carcinoma is particularly important because the treatment approach can be altered. In this report, we present a rare case of laryngeal verruca vulgaris that was diagnosed on the basis of histopathological features.

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Overview of recurrent respiratory papillomatosis

Cited by 99 publications

References 70 publications

Pilot Study: Effect of 3,3′-Diindolylmethane Supplements on Urinary Hormone Metabolites in Postmenopausal Women With a History of Early-Stage Breast Cancer

Pilot Study: Effect of 3,3′-Diindolylmethane Supplements on Urinary Hormone Metabolites in Postmenopausal Women With a History of Early-Stage Breast Cancer

3,3′-Diindolylmethane Is a Novel Mitochondrial H+-ATP Synthase Inhibitor that Can Induce p21Cip1/Waf1 Expression by Induction of Oxidative Stress in Human Breast Cancer Cells

Laryngeal Verruca Vulgaris Presenting with Dysphonia: A Case Report

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