Overview of Radiosensitivity of Human Tumor Cells to Low-Dose-Rate Irradiation

Immune Response During Therapy With Cisplatin or Radiation for Human Papillomavirus–Related Head and Neck Cancer

“…sitivity of human tumor cell lines was correlated with the genotype-that is, cells with more mutations, such as p53 mutations, were more sensitive to radiation therapy. 18 Carcinoma cells (RKO) transformed with E6 and E7 exhibited alterations in cell cycle progression but not in radiosensitivity compared with baseline RKO cells. 19 This is similar to the findings that HPV-positive HNSCC and MTECs are more resistant to radiation therapy than are HPV-negative cells.…”

The DNA-dependent protein kinase (DNA-PK): More than just a case of making ends meet?

“…[143][144][145] While p53 loss (either by mutation abolishing p53 binding to DNA or at the gene level ablating p53 protein expression) correlated with dramatically increased resistance to IR, ablated p21 expression did not correlate with IR sensitivity. 144 This result was controversial as the loss of p21 has been shown to dramatically sensitize a range of cell lines to many other types of DNA damage 119,146,147 suggesting that the default cellular response to DNA damage is to induce apoptosis and that cells express p21 to mediate cell cycle arrest and inhibit apoptosis.…”

Evaluation of cytotoxic and tumor targeting capability of 177Lu-DOTATATE-nanoparticles: a trailblazing strategy in peptide receptor radionuclide therapy

“…Interestingly, this cell line displayed a seesaw behavior in survival rate in response to irradiation. Irradiation of U87MG with IR triggers complex cellular response and cellular radio-sensitivity and redistribution in cell cycle are strongly time dependent [7,8]. During cell cycle, cells pass through checkpoints: G1 and G2, that allow cellular damage to be repaired before proceeding to next phase.…”