Overview of Phosphoinositide Hydrolysis

Kendall, David A.

doi:10.1002/0471141755.ph0203s00

Cited by 1 publication

(1 citation statement)

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“…IP 3 opens the Ca 2+ channels in the platelet dense tubular system (DTS), which triggers Ca 2+ influx through the plasma membrane. DAG activates protein kinase C isoforms in the presence of Ca 2+ , mediating platelet shape changes, platelet granule secretion, and also platelet aggregation [ 139 , 140 ]. Thrombin is the most powerful platelet activator, along with collagen.…”

Section: Overview Of Platelet Functionmentioning

confidence: 99%

Effects of Exogenous Androgens on Platelet Activity and Their Thrombogenic Potential in Supraphysiological Administration: A Literature Review

Roşca

Vlădăreanu

Mititelu

et al. 2021

JCM

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Anabolic androgenic steroids (AAS), simply called “androgens”, represent the most widespread drugs used to enhance performance and appearance in a sporting environment. High-dosage and/or long-term AAS administration has been associated frequently with significant alterations in the cardiovascular system, some of these with severe endpoints. The induction of a prothrombotic state is probably the most life-threatening consequence, suggested by numerous case reports in AAS-abusing athletes, and by a considerable number of human and animal studies assessing the influence of exogenous androgens on hemostasis. Despite over fifty years of research, data regarding the thrombogenic potential of exogenous androgens are still scarce. The main reason is the limited possibility of conducting human prospective studies. However, human observational studies conducted in athletes or patients, in vitro human studies, and animal experiments have pointed out that androgens in supraphysiological doses induce enhanced platelet activity and thrombopoiesis, leading to increased platelet aggregation. If this tendency overlaps previously existing coagulation and/or fibrinolysis dysfunctions, it may lead to a thrombotic diathesis, which could explain the multitude of thromboembolic events reported in the AAS-abusing population. The influence of androgen excess on the platelet activity and fluid–coagulant balance remains a subject of debate, urging for supplementary studies in order to clarify the effects on hemostasis, and to provide new compelling evidence for their claimed thrombogenic potential.

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Section: Overview Of Platelet Functionmentioning

confidence: 99%