Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics

Chamoli, Ambika; Gosavi, Abhishek; Shirwadkar, Urjita P.; Wangdale, Khushal V.; Behera, Santosh Kumar; Kurrey, Nawneet K.; Kalia, Kiran; Mandoli, Amit

doi:10.1016/j.oraloncology.2021.105451

Cited by 161 publications

(93 citation statements)

References 93 publications

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“…The most elevated excess absolute risk of developing solid cancer was observed for tumors of the oral cavity (overall 2.66 EAR, of which 1.08 tongue, 0.68 lip, 0.47 gum, and 0.43 salivary gland) [ 30 ]. GvHD is not present only in FA patients and it is one of the main risk factors for oral cancer [ 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

Tongue cancer following hematopoietic cell transplantation for Fanconi anemia

et al. 2022

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Objectives The aim of this retrospective study was to determine the incidence and the clinical outcome of tongue cancer (TC) in patients affected by Fanconi anemia (FA) who received an allogeneic hematopoietic cell transplantation (HCT). Materials and methods The patient database from the Bone Marrow Transplant Center of Pescara was reviewed to enroll FA patients. Patients’, donors’, HCT’s, and screening’s data were collected as well to look for the incidence and the treatment of TC. Results Twelve patients affected by FA were identified. Three patients died for transplant-related causes. Five of nine surviving patients were diagnosed with TC at a median of 21.7 years since transplantation and at a median age of 32.10 years. Interestingly, no patient manifested graft-versus-host-disease (GvHD). The 28-year cumulative incidence function of TC was 46.9% (95% CI, 36.9–56.9%). Two patients were treated with chemotherapy alone, two patients were treated with surgery alone, and one with surgery followed by chemotherapy. Overall, 4 patients with TC showed a clinical course characterized by a marked aggressiveness of the tumor disease which led to death due to cancer progression between 2 and 13 months. One patient is surviving 8 months after diagnosis of TC. Conclusions Our study confirms the high incidence of tumors and in particular tongue tumors in allotransplanted FA patients. A careful screening has to be life-long maintained. Clinical relevance Considering the rarity of FA and the frailty of FA patients, this study may add important information for the cancer management of these patients.

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Section: Discussionmentioning

confidence: 99%

Tongue cancer following hematopoietic cell transplantation for Fanconi anemia

et al. 2022

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“…Also, human saliva presents organic and inorganic molecules, proteins, peptides, and electrolytes, representing more than 100 biomarkers [22][23][24], pointing to pathological predictors such as viruses, cytokines (IL-1b, IL-8, TNF-α), protein receptors (CD44) [23,24], and DNA and RNA markers [24][25][26]. Also, self-examination is an effective strategy for reducing the levels of mortality and morbidity caused by this pathology, making clear the importance of health education in improving people's living conditions [1,2]. The dentist discloses the information, in addition to providing guidance, and encouraging self-examination so that it can be diagnosed early, preventive work, giving the chance of cure [1][2].…”

Section: Vol 3 Suppl 4 Year 2022mentioning

confidence: 99%

“…Also, self-examination is an effective strategy for reducing the levels of mortality and morbidity caused by this pathology, making clear the importance of health education in improving people's living conditions [1,2]. The dentist discloses the information, in addition to providing guidance, and encouraging self-examination so that it can be diagnosed early, preventive work, giving the chance of cure [1][2].…”

Section: Vol 3 Suppl 4 Year 2022mentioning

confidence: 99%

“…The etiology of Oral Cancer (OC) is multifactorial, resulting from several factors that predispose to the development of this pathology, with a high incidence and mortality, and is among the 10 most common pathologies in the world [1,2]. The areas that suffer most from the disease are the tongue, specifically the posterior lateral border, mouth floor, gums, mucosa, tonsils, retromolar region, dorsum of the tongue, soft palate, and hard palate [3,4].…”

Section: Introductionmentioning

confidence: 99%

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Investigation of the incidence of oral cancer in the municipalities of the state of Sao Paulo-Brazil: a retrospective observational cross-sectional study

Souza¹,

Rossini²,

Araujo³

et al. 2022

MedNEXT

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Introduction: The etiology of Oral Cancer (OC) is multifactorial, resulting from several factors that predispose to the development of this pathology, with a high incidence and mortality, and is among the 10 most common pathologies in the world. Objective: It was to carry out a retrospective longitudinal observational study on the incidence of oral cancer in patients treated at public health units in the municipalities of the State of Sao Paulo-Brazil, as well as to present the main clinical and demographic characteristics of these patients. Methods: This study followed a retrospective observational cross-sectional model (2018-2022), following the rules of clinical research of the STROBE. The present study used the database of the public health system in Brazil on the incidence and prevalence of oral cancer in health units in 467 municipalities in the State of São Paulo-Brazil, whose data are available for public consultation and do not require approval. by the research ethics committee. Participants with oral cancer records of different ethnicities, aged over 20 years, and of both genders were included. Participants who had missing registration data were excluded. For data analysis, the database was built in a Microsoft Excel spreadsheet, which was exported to the Minitab 18® statistical program. One-Way ANOVA with p>0.05 was applied without a statistical difference in the CI95%. Results: The total number of municipalities in the State of São Paulo-Brazil analyzed was 467. Suspected oral malignancy did not present a significant statistical difference between the years 2018 and 2019 (0.33% vs. 0.30%), with p>0.05 in CI95 %. The highest incidences of suspected oral malignancy occurred in 2018 and 2019. In addition, it was evidenced that the most frequent histological type was squamous cell carcinoma in all the years analyzed. Also, bad habits such as alcoholism, smoking, excessive exposure to the sun, and also genetic predisposition, the presence of HPV did not show to influence statistically the occurrences of oral neoplasms. Conclusion: Based on the objective of this study, the incidence of oral cancer in the municipalities of the state of São Paulo-Brazil was higher in the years 2018 and 2019, regardless of the action of predictors such as smoking, alcohol consumption, HPV, genetic predisposition and age. However, further studies need to be carried out in the periods from 2020 to 2022 to know the population that was absent due to the COVID-19 pandemic.

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“…Oral squamous cell carcinoma (OSCC) is the most commonly occurred malignancy in the oral cavity [ 1 ]. Most OSCCs are correlated with oral precursor lesions [ 2 ], and the 5-year overall survival of OSCC patients is less than 40% [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

A prognostic Risk Score model for oral squamous cell carcinoma constructed by 6 glycolysis-immune-related genes

Liu

Wang

2022

BMC Oral Health

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Background Oral squamous cell carcinoma (OSCC) is the most frequent tumor of the head and neck. The glycolysis-related genes and immune-related genes have been proven prognostic values in various cancers. Our study aimed to test the prognostic value of glycolysis-immune-related genes in OSCC. Methods Data of OSCC patients were obtained from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Enrichment analysis was applied to the glycolysis- and immune-related genes screened by differential expression analysis. Univariate Cox and LASSO Cox analyses were used to filtrate the genes related to the prognosis of OSCC and to construct Risk Score model. Results A Risk Score model was constructed by six glycolysis-immune-related genes (including ALDOC, VEGFA, HRG, PADI3, IGSF11 and MIPOL1). High risk OSCC patients (Risk Score >−0.3075) had significantly worse overall survival than that of low risk patients (Risk Score <−0.3075). Conclusions The Risk Score model constructed basing on 6 glycolysis-immune-related genes was reliable in stratifying OSCC patients with different prognosis.

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Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics

Cited by 161 publications

References 93 publications

Tongue cancer following hematopoietic cell transplantation for Fanconi anemia

Tongue cancer following hematopoietic cell transplantation for Fanconi anemia

Investigation of the incidence of oral cancer in the municipalities of the state of Sao Paulo-Brazil: a retrospective observational cross-sectional study

A prognostic Risk Score model for oral squamous cell carcinoma constructed by 6 glycolysis-immune-related genes

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