Overview of Operations for Morbid Obesity

Deitel, Mervyn

doi:10.1007/s002689900494

Cited by 73 publications

(49 citation statements)

References 35 publications

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“…The gastrectomy aspect of the BPD was reported to reduce food ingestion in human patients, in whom it has a temporary and perhaps limited effect on weight loss. 10,24 In addition to an initial reduction in food intake, the BPD also led to nutrient malabsorption, which likely contributed to the long-term reducing effects of the surgery on body fat reserves. Indeed, fecal energy density stayed consistently higher in the BPD-operated rats compared to both controls and sham rats.…”

Section: Discussionmentioning

confidence: 99%

Effects of the biliopancreatic diversion on energy balance in the rat

Nadreau

Samson

et al. 2005

Int J Obes

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Objective: This study was carried out to determine the effects of the biliopancreatic diversion (BPD), a bariatric surgery applied to the treatment of morbidly obese humans, on energy balance in rats. Methods: BPD was performed on a group of male Wistar rats. Body weight and food intake were measured daily throughout the study. Feces were also collected to assess energy losses and the determination of digestible energy. Energy expenditure and body composition were also determined for the 50-day length of the protocol. On the day of killing, the brain, the entire intestinal tract and white and brown adipose tissues were collected and weighed. Expression of neuropeptide Y (NPY) and agouti-related protein (AgRP) in the ARC nucleus were assessed by in situ hybridization. Results: Marked changes in the regulation of energy balance were observed in the BPD-operated rats. A decrease in digestible energy and food intake coupled with an increase in the fecal energy density and protein fecal energy led to an important weight loss in the BPD-operated rats. This weight loss was observed in the loss of fat mass (specifically the white epididymal, inguinal, retroperitoneal and brown adipose tissues). The rats modified their food intake pattern to be able to potentially eat more during the entire day. An increase in the surfaces of all intestinal structures (muscular and mucosal layers) was observed in the BPDoperated rats. The NPY and AgRP expression in the brain were both shown to be greater in the BPD-operated rats than in the control animals. At the beginning of the study, the surgery led to an energy expenditure decrease, which, however, did not persist throughout the study despite the fact that BPD-operated rats exhibited persistent lower fat free masses. Conclusion: BPD led to a noticeable reduction in weight and fat gains in rats, which was in large part owing to a decrease in digestible energy intake led to by the gastrectomy, the intestinal malabsorption inherent to the surgery and to potentially a thermogenesis stimulation that occurred in the second end of the study. The reduction in energy gain occurs despite adaptations to thwart the intestinal malabsorption and the hunger signals from the central nervous system.

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Section: Discussionmentioning

confidence: 99%

Effects of the biliopancreatic diversion on energy balance in the rat

Nadreau

Samson

et al. 2005

Int J Obes

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“…2,3 Following the same principle, the Jejunocolic bypass was introduced followed by, the jejunoileal bypass. 4 Along with its side effects of mineral and vitamins loss, purely malabsorption procedures failed to maintain weight loss due to bowel adaptation. 5 The gastric restriction approach followed in the 1960s with gastric pouch and Billroth II gastrectomy.…”

Section: Introductionmentioning

confidence: 99%

Laparoscopic Instruments Marking Improve Length Measurement Precision

Isreb¹,

Hildreth²,

Mahawar³

et al. 2009

WJOLS

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“…Este procedimiento ha mostrado inducir y mantener una pérdida satisfactoria de peso 35,37,41 y en estudios nacionales se han reportado altas tasas de éxito [38][39][40] . La técnica consiste en la fabricación de un reservorio gástrico proximal (aproximadamente 15 a 30 mL) totalmente separado del resto del estómago, que se une a un segmento proximal de yeyuno de 150-200 cm de largo, a través de un estoma de 1 cm de diámetro.…”

Section: Tratamiento Quirúrgico De La Obesidadunclassified

Tratamiento farmacológico o quirúrgico del paciente con sobrepeso u obesidad

Carrasco

Manrique²,

Maza

et al. 2009

Rev. méd. Chile

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This is an updated review of the available treatments for obesity, that can be used when lifestyles modifications fail. Using the available information and the experience of the members of this advisory group, a recommendation is givenA demás de las medidas no farmacológicas, el uso de medicamentos puede ser de utilidad en algunos pacientes con sobrepeso u obesidad.Según consenso internacional, se justifica el uso de fármacos en obesidad cuando fracasa el tratamiento con dieta, ejercicio y manejo conductual en pacientes con IMC >30 kg/m 2 o con IMC >27 kg/ m 2 y comorbilidades de relevancia médica (diabetes tipo 2, hipertensión arterial, dislipidemia, artropatía, etc.) 1 .En la indicación de un tratamiento farmacológico en obesos se deben considerar los factores etiológi-

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Overview of Operations for Morbid Obesity

Cited by 73 publications

References 35 publications

Effects of the biliopancreatic diversion on energy balance in the rat

Effects of the biliopancreatic diversion on energy balance in the rat

Laparoscopic Instruments Marking Improve Length Measurement Precision

Tratamiento farmacológico o quirúrgico del paciente con sobrepeso u obesidad

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