Overview of milling techniques for improving the solubility of poorly water-soluble drugs

Loh, Zhi Hui; Samanta, Asim Kumar; Heng, Paul Wan Sia

doi:10.1016/j.ajps.2014.12.006

Cited by 354 publications

(230 citation statements)

References 140 publications

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“…When reaching the critical speed the balls can achieve the highest point of the mill without detaching the wall. Above the critical velocity, it is possible to observe the cataract effect, as shown in Zone C of Figure 1 [12] .…”

Section: Introductionmentioning

confidence: 99%

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Effect of shrimp shells milling on the molar mass of chitosan

et al. 2017

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Section: Introductionmentioning

confidence: 99%

“…The balls compose the milling elements and drive rollers help to rotate the milling chamber. Adapted from Loh et al [12] . 1000), to be used in determining the PSD.…”

Section: Chitosan Characterizationmentioning

confidence: 99%

Effect of shrimp shells milling on the molar mass of chitosan

et al. 2017

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“…Fine drug particulates are especially desired in formulations designed for parenteral, respiratory and transdermal use. Most drugs after crystallization have to be comminuted and this physical transformation is required to various extents, often to enhance processability or solubility especially for drugs with limited aqueous solubility [48]. Qing Yao et al [49] reported redispersion of the shell-forming nanoparticles to improve oral bioavailability of core-shell structured beads.…”

Section: Dispersion Of Nanoparticles By Beads Millmentioning

confidence: 99%

“…Also, nanocrystalline solid dispersion of coenzyme Q10 prepared with cold wet-milling system to enhance the dissolution and biopharmaceutical properties of CoQ10 [50]. The mechanisms by which milling enhances drug dissolution and solubility altering in the size, specific surface area and shape of the drug particles as well as milling induced amorphization and/or structural disordering of the drug crystal (mechano-chemical activation) [48].…”

Section: Dispersion Of Nanoparticles By Beads Millmentioning

confidence: 99%

Nanotechnology: Development and challenges in Indonesia

Joni

Muthukannan

Hermawan

et al. 2018

AIP Conference Proceedings

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Abstract. Nanotechnology today is regarded as a revolutionary technology that can help to address the key needs related to energy, environment, health and agriculture in developing countries. This paper is a short review on the development and challenges of nanotechnology in Indonesia. Nanotechnology offers great potential benefits, there is emerging concerns arising from its novel physicochemical properties. The main applications of nanotechnology in the different sectors which is vital and its economic impact in Indonesia is also discussed. The achievment and development of nanotechnology including synthesis and dispersion of nanoparticles (NPs) and its applications in various fields is briefly addressed in Nanotehcnology and Graphene Research Center, Universitas Padjadjaran (Unpad). Despite significant progress in developmental goals, many challenges in the development of nanotechnology proccesing need to be resolved such as support infrastructure and evolution of new form of collaborative arrangements between various sectors and policies which is emerged as an important factor enabling development.

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“…Pharmaceutical researchers are constantly working on various approaches for the enhancement of drug solubility and dissolution of BCS Class II drugs which improve the therapeutic responses and overcome the toxic effects related to the higher dose. [1][2][3][4][5][6][7][8] For the enhancement of solubility and dissolution, pharmaceutical scientists have been used various approaches such as particle size reduction, i.e., micronization and nanoformulations, [9] salt formation, [10] prodrug and drug derivatization, [11] cosolvency, [12] use of surfactants, [13] cyclodextrin complexes, [14] change in crystal habit or cocrystals, [6] self-emulsifying drug delivery systems, [15] solid dispersions, [16] etc. Each technique has its own merits and demerits regarding solubility enhancement and selection of suitable one is mainly depends on the type of drug, polymers, therapeutic, and targeted delivery of drug which to be obtained.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Budhwar¹

2018

AJP

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Inclusion complexes have various applications in different fields of drug delivery and pharmaceutical industry due to their ability of complexation with guest molecules and enhancement of the physicochemical properties of guest molecules. Cyclodextrins and their derivatives have the ability to encapsulate the bioactive compounds into its cavity and protect these from the environmental conditions, improve the solubility, bioavailability, and other properties also. The aim of this review is to highlight the advantages of cyclodextrins in the enhancement of physicochemical properties of drugs (such as solubility, stability, bioavailability, permeability, and others), different methods for production and various characterization techniques used for evaluation of complexes. Applications of cyclodextrin complexes in pharmaceutical and other fields are also explained here with examples. Thus cyclodextrins, because of their continuing ability to find several novel applications in drug delivery, are expected to solve many problems accompanied with the delivery of different novel drugs through various delivery routes.

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Overview of milling techniques for improving the solubility of poorly water-soluble drugs

Cited by 354 publications

References 140 publications

Effect of shrimp shells milling on the molar mass of chitosan

Effect of shrimp shells milling on the molar mass of chitosan

Nanotechnology: Development and challenges in Indonesia

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