Overview of Magnesium Research: History and Current Trends

Protein Side Chains Facilitate Mg/Al Exchange in Model Protein Binding Sites

“…In fact, post-mortem analysis of brain tissues of patients suffering from neurodegenerative diseases reveals substantial magnesium depletion in some of the most affected areas of the brain, where a high concentration of aluminum has been found. [14][15][16][17] However, the connection between aluminum uptake and development of neurodegenerative disease is still highly speculative. [18] The molecular basis of these interferences have not been addressed, as far as we know.…”

A study of the coordination shell of aluminum(III) and magnesium(II) in model protein environments: Thermodynamics of the complex formation and metal exchange reactions

“…Mg(II) seems to be one of the most affected cations, since the two cations are similar in size, which is a dominant factor over the charge identity in terms of metal ion competition [22,23]. Some authors point out the substitution of Al(III) for Mg(II) in various binding sites as one of the causes of neurodegeneration in some maladies as Alzheimer's disease [21,[24][25][26][27]. In fact, post-mortem analysis of neurodegenerative disease patients reveals a substantial magnesium depletion in some of the most affected areas of the brain [24][25][26][27].…”

Alterações do metabolismo da glicose na deficiência de magnésio

“…Porém, de acordo com a hipótese sobre o controle hormonal da homeostase de Mg, proposto por Durlach & Durlach (1984), durante a deficiência deste cátion ocorreria um aumento da secreção de insulina e adrenalina na tentativa de manter a concentração de Mg celular e, secundariamente, manter o nível de AMPc (adenosina 3', 5'-monofosfato cíclica). Esta indução reativa da secreção de insulina poderia resultar do desaparecimento do efeito inibitório do Mg sobre esta secreção, eventualmente associado à forte estimulação das células β pancreáticas em virtude de um aumento do cálcio (Ca) intracelular.…”