Overview of laboratory diagnostic methods used in nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) at the modern stage

Тарасова, Л. В.; Tsyganova, Julia V.; Opalinskaya, I.V.; Иванова, А. Л.

doi:10.31146/1682-8658-ecg-164-4-72-77

Cited by 7 publications

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References 12 publications

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“…The importance of an adequate and timely assessment of the severity of the pathological process in the liver is beyond doubt: it is necessary in clinical practice to determine the stage, prognosis of the disease and the ability to timely adjust the tactics of treating patients [19,20]. The use of modern instrumental methods has significantly expanded the amount of information received on the detection rate, periods of early development of liver diseases [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Novel Method for Quantifying Hepatic Steatosis in Patients With Metabolically Associated Fatty Liver Disease

Борсуков

Venidiktova

Borsukov

2022

IJIM

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Introduction. The article presents an overview of novel complex algorithm based on methods of ultrasound steatometry, combined elastography and dual-energy X-ray absorbtiometry in “Whole body” mode in diagnostic and monitoring of metabolically associated fatty liver disease.The purpose of the study: to assess the possibility of quantitative ultrasound steatometry using in the detection and monitoring of metabolically associated fatty liver disease.Material and methods. 157 patients were examined. The main group consisted of 47 patients with liver steatosis; 45 patients with steatohepatitis and clinically insigniﬁcant liver ﬁbrosis (F0-F1); 32 patients with steatohepatitis and clinically signiﬁcant liver ﬁbrosis (F2-F3); 33 patients with focal hepatic steatosis. We used complex algorithm based on methods of questionnaires, laboratory tests, ultrasound steatometry, combined elastography and dual-energy x-ray absorbtiometry in “Whole body” mode, liver biopsy. to determine the severity of steatosis, a scale was used: S0 – no steatosis; 2.9 dB/cm.Results and conclusion. It is possible to use quantitative ultrasound steatometry for metabolically associated fatty liver disease, as a reference method both for the initial detection of the disease and for monitoring non-drug treatment (sensitivity 90.7%, speciﬁcity 92.4%). The optimal complex for the diagnosis and monitoring of non-drug treatment of metabolically associated fatty liver disease includes an assessment of the level of compliance, the use of quantitative ultrasound steatometry and dual-energy X-ray absorptiometry in the «Whole body» mode (sensitivity 92.8%, speciﬁcity 92.3%).

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Section: Introductionmentioning

confidence: 99%

Novel Method for Quantifying Hepatic Steatosis in Patients With Metabolically Associated Fatty Liver Disease

Борсуков

Venidiktova

Borsukov

2022

IJIM

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“…Correlation of secreted frizzled related protein-4 adipokin expression and expression of fatty liver changes under the conditions of a chronic experiment * L. V. Tarasova 1, 2, 3 , V. N. Diomidova 1,4 , N. V. Tolmacheva 1 , Yu. V. Tsyganova 1 , A. L. Ivanova 1,4 , J. V. Maslova 1 , E. V. Barsukova 1,3 снижению образования в клетках гликогена, способствует повышению жироотложения, развитию морфофункциональных нарушений внутренних органов и систем. Чаще всего, клинически указанные процессы выражаются в ожирении (в первую очередь, висцеральном), нарушении толерантности к глюкозе, метаболическом синдроме, сахарном диабете, их компонентах и осложнениях [1].…”

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“…Своевременная диагностика и лечение НАЖБП -наиболее актуальная проблема современной гепатологии. Во-первых, вследствие её высокой распространённости [2], во-вторых -отсутствия информативных лабораторных маркёров [3], в-третьих -недостаточной эффективности имеющихся лекарственных препаратов [4].…”

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“…FSBEI of HE "The Chuvash State University n. a. I. N. Ulyanov", 15, Moskow avenue, 428015, Cheboksary, Russia 2. BI of HE "The Surgut State University", 1 Lenina street, 628412, Khanty-Mansi Autonomous Region -Ugra, Surgut, Russia 3. BU ChR "Republican Clinical Hospital" of the Ministry of Health of the Chuvash Republic, 9 Moskovsky prospect, 428018, Chuvash Republic, Cheboksary, Russia 4 BU ChR "City Clinical Hospital No.…”

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Correlation of secreted frizzled related protein-4 adipokin expression and expression of fatty liver changes under the conditions of a chronic experiment

Тарасова

Николаевна

Толмачёва

et al. 2021

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The article highlights the results of a study of a new method for diagnosing non-alcoholic fatty liver disease in a living organism by determining the serum level of the marker Secreted frizzled related protein-4 (SFRP4) with histological confirmation of the results. In a chronic experiment, the parameters of two groups of experimental animals were studied: control and experimental, 15 rats each. The control (reference) group of animals was in the usual feed and drinking mode, the experimental received food with a high content of carbohydrates and fats. The results of biochemical blood tests and autopsy biomaterials on day 180 of the experiment indicated the presence of fatty changes in the liver in the experimental group of animals. The importance of circulating adipokine SFRP4 in the diagnosis of non-alcoholic fatty liver disease (NAFLD) has been confirmed. A histologically confirmed direct correlation of SFRP4 with the degree of liver fibrosis in NAFLD was revealed. The place of SFRP4 in the pathogenesis of non-alcoholic fatty liver damage is explained. It is noted that in case of successful extrapolation of the results of the study on the human body, information will become a successful solution to one of the most pressing problems of modern hepatology.

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A method of diagnosing non-alcoholic fatty liver disease with the calculation of the steatosis index

Bulatova,

Sobol,

Gulyaeva

2024

Perm Medical Journal

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Objective. To work out the index for diagnosing non-alcoholic fatty liver disease (NAFLD) in women with metabolic syndrome (MS) in postmenopause using generally available markers. Materials and methods. 62 females with NAFLD and MS in early postreproductive period took part in the study. They were compared to 24 relatively healthy females not suffering from obesity in postmenopause. The average age of the patients was 49,9 ± 1,1. Hepatic steatosis was diagnosed by ultrasound examination. The mathematic model of hepatic steatosis index (HSI) calculation included: body mass index (BMI), waist size (WS), triglycerides and low-density lipoproteins (LDL). Results. BMI and WS in patients with MS and NAFLD in postmenopause were considerably more than in relatively healthy women. Hypertriglyceridemia and an increase of LDL in blood serum were noted in patients with steatosis. Biometric and laboratory data were included in the mathematical formula which allows to calculate HSI. With HSI 0,5 and more NAFLD is diagnosed in women in post menopause, when HSI is lower than 0,5 it is not diagnosed. Indicators of sensitivity and specificity of the method were 98,4 % and 95,85 % respectively. Conclusions. The minimally invasive method suggested above allows to reveal hepatic steatosis in females with MS in early postreproductive period. High diagnostic characteristics of the method are worth mentioning, as well as the possibility to be widely used thanks to simple biometric and laboratory data employed.

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Overview of laboratory diagnostic methods used in nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) at the modern stage

Cited by 7 publications

References 12 publications

Novel Method for Quantifying Hepatic Steatosis in Patients With Metabolically Associated Fatty Liver Disease

Novel Method for Quantifying Hepatic Steatosis in Patients With Metabolically Associated Fatty Liver Disease

Correlation of secreted frizzled related protein-4 adipokin expression and expression of fatty liver changes under the conditions of a chronic experiment

A method of diagnosing non-alcoholic fatty liver disease with the calculation of the steatosis index

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