Overview of host miRNA properties and their association with epigenetics, long non-coding RNAs, and Xeno-infectious factors

Heydarzadeh, Samaneh; Ranjbar, Maryam; Karimi, Farrokh; Seif, Farhad; Alivand, Mohammad Reza

doi:10.1186/s13578-021-00552-1

Cited by 25 publications

(17 citation statements)

References 195 publications

(108 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…miRNAs are short, conserved noncoding RNAs that post-transcriptionally control the expression of targeted genes. 2 Alteration in miRNA expression has been shown to be associated with various types of cancers, including colorectal and breast cancers. 11,12 However, studies conducted to determine the metastatic miRNAs in clinical samples in primary and metastatic breast and colorectal cancer are limited.…”

Section: Discussionmentioning

confidence: 99%

“…The miRNAs are endogenous, short noncoding RNA of 18 to 25 nucleotides that do not encode proteins, but regulates gene expression by targeting messenger RNAs (mRNAs). 2 The miRNAs can bind complementarily with the 3′ untranslated region (3′UTR) of targeted mRNA transcripts to stimulate the degradation of mRNAs or prevent the translation of mRNAs, thereby controlling the expression of at the post-transcriptional level. They are linked with several cellular process including cell cycle, growth, and apoptosis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

MicroRNA Expression of Primary and Metastatic Colorectal and Breast Carcinoma

et al. 2022

View full text Add to dashboard Cite

Background: Colorectal and breast carcinoma are frequently diagnosed cancers. At advanced stages, cancers metastasize to certain organs resulting in loss of function of these organs, and eventually death. Therefore, there is a specific need for the prognosis of these cancers. Currently, microRNAs (miRNAs), have emerged as a new target of cancer-specific biomarker. Objective: To examine the expression of miRNA in primary and metastatic breast and colorectal cancers. Methods: This study investigated the expression of 6 miRNAs (miR-10b, miR-21, miR-145, miR-155, miR-200c, and miR-373) in formalin fixed paraffin embed tissues from pairs of normal tissues with primary and metastatic tumor samples of breast and colorectal carcinoma cases in Ramathibodi Hospital, Thailand by real-time RT-PCR. Results: Among 6 miRNAs, miR-145 decreased significantly in all samples of primary and metastatic colorectal and breast carcinoma. There was significantly decreased expression of miR-145 in metastatic colorectal carcinoma compared to their primary colorectal carcinoma (P < .05). Whereas miR-10b, miR-155, and miR-200c showed a decreased expression; miR-21, and miR-373 showed an increased expression in the majority of cases. Unlike miR-145, other miRNAs showed no significant difference of expression (P > .05). Conclusions: This finding indicates that miR-145 may be the potential metastatic biomarker. Decrease of miR-145 could be applied to the prognosis and target for therapy of breast and colorectal carcinoma.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

MicroRNA Expression of Primary and Metastatic Colorectal and Breast Carcinoma

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Similarly to canonical miRNAs, isomiR expression can discriminate human cancers, [24]. In addition, recent studies have demonstrated that isomiRs could be used as prognostic and diagnostic biomarkers in various cancers and related subtypes; in fact, they can differentiate between healthy and non-healthy individuals [33]. To analyze the contribution of isomiRs to melanoma pathogenesis, we compared the isomiR profile of benign nevi and early-stage primary cutaneous melanoma FFPE samples, and of primary cutaneous melanoma and melanoma metastasis of fresh-frozen samples.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA Isoforms Contribution to Melanoma Pathogenesis

Broseghini

Dika

Londin

et al. 2021

ncRNA

View full text Add to dashboard Cite

Cutaneous melanoma (CM) is the most lethal tumor among skin cancers, and its incidence is constantly increasing. A deeper understanding of the molecular processes guiding melanoma pathogenesis could improve diagnosis, treatment and prognosis. MicroRNAs play a key role in melanoma biology. Recently, next generation sequencing (NGS) experiments, designed to assess small-RNA expression, revealed the existence of microRNA variants with different length and sequence. These microRNA isoforms are known as isomiRs and provide an additional layer to the complex non-coding RNA world. Here, we collected data from NGS experiments to provide a comprehensive characterization of miRNA and isomiR dysregulation in benign nevi (BN) and early-stage melanomas. We observed that melanoma and BN express different and specific isomiRs and have a different isomiR abundance distribution. Moreover, isomiRs from the same microRNA can have opposite expression trends between groups. Using The Cancer Genome Atlas (TCGA) dataset of skin cancers, we analyzed isomiR expression in primary melanoma and melanoma metastasis and tested their association with NF1, BRAF and NRAS mutations. IsomiRs differentially expressed were identified and catalogued with reference to the canonical form. The reported non-random dysregulation of specific isomiRs contributes to the understanding of the complex melanoma pathogenesis and serves as the basis for further functional studies.

show abstract

“…MicroRNAs are non-coding RNA with an 18-25 nucleotides sequence. Their function is to silence targeted mRNA by binding to coding regions, that is, 3′-untranslated regions (Heydarzadeh et al, 2021). Two mechanisms involved in silencing the targeted mRNA are repressing translation by degradation and promoting deadenylation (O'Brien et al, 2018).…”

Section: Micrornas (Mirna)mentioning

confidence: 99%