Overview of Effective Traditional Medicinal Plants having Antihyperlipidemic Activity

Rayadurgam, Sireesha; Manikandan, K.

doi:10.18311/jnr/2022/29791

Cited by 2 publications

(2 citation statements)

References 28 publications

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“…But as these chemical drugs have various side effects 33 , various chemicals isolated from herbal sources can be used in this therapy due to having fewer side effects. Extracts of gum ghatti Anogeissus latifolia 34 , Mangifera indica, grape seeds 35 , citrus peel 36 have been assessed to have hypo cholesterol activity and have been used traditionally for cholesterollowering activity.…”

Section: Pca Analysis Of 24 Samples Of a Crassna Leaf Extracts Based ...mentioning

confidence: 99%

Untitled

2023

IJPSR

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Iriflophenone 3-C-β-D glucoside is a Benzophenone derivative which can be obtained from various plant sources like Aquilaria crassna, A. sinensis, A. malaccensis, Cyclopia genistoides, Mangifera indica, Dryopteris ramosa etc. It can act as an important herbal active constituent as it has various pharmacological actions, such as Antidiabetic, anti-inflammatory, antioxidant, and antimicrobial agent. Some scientists demonstrated the antioxidant activity of Iriflophenone 3-C-β-D glucoside and have seen that this compound has no radical scavenging ability against DPPH [2,2-diphenylpicrylhydrazyl] but scavenged ABTS [2,2'-azino-bis(3ethylbenzothiazoline-6-sulphonic acid)] and peroxyl radicals. So, it can be used as an anti-oxidant agent. From A. sinensis 8 compounds were isolated among which Iriflophenone 3-C-β-D glucoside was present. It is proved that all the isolated compounds have α-glucosidase inhibition activity stronger than acarbose, that is taken as positive drug control. Aqueous fraction of D. ramosa is used for so long by the inhabitants of the Galliyat region of Pakistan to treat their GIT ailments caused by bacteria. Scientists showed that Iriflophenone 3-C-β-D glucoside that is obtained from Dryopteris ramosa has stronger antibacterial potential against Klebsiella pneumoniae, Staphylococcus aureus, and Escherichia coli. The antiinflammatory activities of this compound are revealed as the aqueous extract of A. crassna expressed strong IL-1α and IL-8 inhibitions and the 70% Ethanolic extract showed IL-1α and NO inhibitions. Apart from this there are many other effects of that compound which are still under research. Such versatile uses make this compound a highly valuable herbal constituent. INTRODUCTION:Iriflophenone 3-C-β-D glucoside is a Benzophenone derivative. The IUPAC name of this compound is (4hydroxyphenyl) -[2, 4, 6trihydroxy -6 -(hydroxyl-methyl) oxan -2 -yl] phenyl] methanone. The molecular weight of this compound is 408.4 g/mol. This compound is obtained through the shikimic acid pathway.

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Section: Pca Analysis Of 24 Samples Of a Crassna Leaf Extracts Based ...mentioning

confidence: 99%

Untitled

2023

IJPSR

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“…They can be genetically modified to use it more beneficially and precisely for the needed specific therapeutic effects. So, medicinal plant can be a noteworthy replacement of available synthetic drugs [5][6][7]. Among these Coccinia grandis demonstrated notable reductions in cholesterol and triglycerides [8].…”

Section: Introductionmentioning

confidence: 99%

An Evaluation of Anti-hyperlipidemic Activity of Ethanolic Extract of Coccinia grandis Leaves in High Fat Induced Rodent Model

Nisu,

Nadvi,

Ankhi

et al. 2024

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In the realm of health research, hyperlipidemia is a condition that has lately become prevalent and is a serious issue. Elevated lipid levels in an individual's body are the primary indicator of hyperlipidemia, a condition defined by increased levels of low-density lipoprotein (LDL), total cholesterol, triglycerides, and high lipoprotein levels. Several pharmacological agents are accessible for the treatment of hyperlipidemia. Nevertheless, human beings throughout the globe also thrive on nature-derived therapeutic items. Coccinia grandis is a noteworthy plant known for its antihyperlipidemic properties among them. In this study, we provided a high-fat diet for the experimental rats to generate hyperlipidemia conditions in this rat model. As per our research methodology, Coccnia grandis was administered to all the rats in the treatment group at three (low, medium and high) distinct dosages. It is eventually revealed that Coccnia grandis may successfully lower (p<0.05) the hyperlipidemic state in both medium and high dosages. Elevated and unusual Triglyceride and Total Cholesterol were observed to be restored following Coccnia grandis medication. However, in the case of HDL and LDL, no substantial drop was detected. A considerable restoration was noted similarly in both instances of SGPT and SGOT. These findings show that our plant has components with antihyperlipidemic action, however the concentrations did not meet the necessary threshold. So, additional investigations are needed to examine the chemical structure and the quantities of the molecule as well as find out about genetic alterations.

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Overview of Effective Traditional Medicinal Plants having Antihyperlipidemic Activity

Cited by 2 publications

References 28 publications

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An Evaluation of Anti-hyperlipidemic Activity of Ethanolic Extract of Coccinia grandis Leaves in High Fat Induced Rodent Model

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