Overview of clinical experiences on carbon ion radiotherapy at NIRS

Tsujii, Hirohiko; Mizoe, Jun Etsu; Kamada, Tadashi; Baba, Masayuki; Kato, Shingo; Kato, Hirotoshi; Tsuji, Hiroshi; Yamada, Shigeru; Yasuda, Shigeo; Ohno, Tatsuya; Yanagi, Takeshi; Hasegawa, Azusa; Sugawara, Toshiyuki; Ezawa, Hidefumi; Kandatsu, Susumu; Yoshikawa, Ken; Kishimoto, Riwa; Miyamoto, Tadaaki

doi:10.1016/s0167-8140(04)80012-4

Cited by 205 publications

(153 citation statements)

References 19 publications

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“…The extent of cell death after charged-particle irradiation may depend on irreparable DNA double-strand breaks (8,9). Therefore, phase I/II studies of heavy carbon-ion beam irradiation have been undertaken for the treatment of esophageal squamous cell carcinoma (SCC) and have produced encouraging results (10,11). Although the local control rate of heavy-ion radiation was better than Xrays alone, it was not better than chemoradiation therapy.…”

Section: Introductionmentioning

confidence: 99%

Synergistic growth suppression induced in esophageal squamous cell carcinoma cells by combined treatment with docetaxel and heavy carbon-ion beam irradiation

Kitabayashi

Shimada²,

Yamada³

et al. 2006

Oncol Rep

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Abstract. Heavy carbon-ion beam therapy has revealed several potential advantages over X-rays. Heavy-ion therapy has been applied for various solid tumors including esophageal squamous cell carcinoma (SCC). Although the local control rate of carbon ion radiotherapy for esophageal cancer has revealed better rates than that of conventional radiotherapy, some patients have shown resistance to the treatment. No study has evaluated whether anti-cancer drugs can enhance the anti-tumor effect of heavy carbon-ion beam irradiation. Therefore, we evaluated the efficacy of docetaxel, fluorouracil, cisplatinum, doxorubicin and gemcitabine to enhance the anti-tumor effects of heavy carbon-ion beam irradiation on human esophageal SCC cells in both in vitro and in vivo experiments. Fluorouracil, cisplatinum, doxorubicin and gemcitabine showed only additive anti-tumor effects. On the other hand, growth suppression was significantly potentiated by the combined treatment with heavy carbon-ion beam and docetaxel as compared to that treated with either agent alone. These data suggest that heavy carbon-ion beam irradiation combined with docetaxel may be a potentially useful therapeutic strategy for locally advanced esophageal SCC.

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Section: Introductionmentioning

confidence: 99%

Synergistic growth suppression induced in esophageal squamous cell carcinoma cells by combined treatment with docetaxel and heavy carbon-ion beam irradiation

Kitabayashi

Shimada²,

Yamada³

et al. 2006

Oncol Rep

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“…Relative biological effectiveness (RBE) values reach a maximum at a LET of 100-200 keV/µm [1,3,8,22]. High-LET heavy ions have a more selective dose distribution as well as a higher RBE, and have been applied to radiotherapy in human patients for the treatment of malignant tumors in the lung [11], brain [12], liver [15], and prostate tissues [26]; this treatment has been shown to be more effective than therapy using conventional low-LET photons [25]. Although it is highly likely that heavy-ion radiotherapy is a promising modality, the application of heavy ions in veterinary clinics is unreported.…”

mentioning

confidence: 99%

Killing of Feline T-Lymphocytes by Gamma-Rays and Energetic Carbon Ions

Kakizaki

Hamada

Funayama

et al. 2006

The Journal of Veterinary Medical Science

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ABSTRACT. High linear energy transfer (LET) heavy charged particles have previously been applied clinically to human cancer radiotherapy because of their excellent physical properties of selective dose distribution and higher relative biological effectiveness (RBE) for human; however, such an approach has yet to be applied to cat patients. The present study investigates the biological effectiveness of low-LET γ-rays (0.2 keV/µm) compared to high-LET carbon ions (114 keV/µm) in feline T-lymphocyte FeT-J cells. Clonogenic survival analysis revealed that the RBE value of carbon ions was 2.98 relative to a 10% survival dose (D 10 ) by γ-rays, and that the inactivation cross-section in cells exposed to γ-rays and carbon ions was 0.023 and 38.9 µm 2 , respectively. Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL) analysis revealed that TUNEL-positive frequency in carbon-irradiation cells is higher than for γ-irradiated cells against exposure to the same physical doses, but that very little difference in TUNEL-positive frequency is observed between cells exposed to the respective D 10 dose of γ-rays. Our data thus indicate that carbon ions are more effective for cell killing than γ-rays at the same physical doses, but kill cells to an extent that is comparable to γ-rays at the same biological doses. Carbon ion radiotherapy is therefore a promising modality for cat patients. KEY WORDS: accelerated carbon ions, apoptosis, feline T lymphocytes, gamma-ray, relative biological effect.

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“…The beam energy will be degraded by bring in the ridge filter [21,22]. After the ridge filter, the Spread-Out Bragg peak will be produced to cover the target in depth with a relatively homogeneous RBE-weighted dose [2][3][4]. The SOBP dose distribution span depends on the period of the ridge filter structure and the angular straggling of the ridge filter placement.…”

Section: Description Of the Treatment Head At Impmentioning

confidence: 99%

“…Over the past 30 years, ion beam radiotherapy using particles like proton, helium, carbon ions has been gradually and slowly increasingly in popularity in radiation oncology [1][2][3].The inverted depth dose profile ⎯the increase of dose along the penetration depth (the Bragg Peak) and a sharp drop after the Bragg Peak ⎯ make ion beams an ideal tool for treatment of the deepseated tumours [1][2][3][4][5][6][7]. For carbon ions, the excellent dose profile is further boosted by an additional increase in the relative biological effectiveness (RBE) along the depth till the end of the particle range [2-4, 6, 8].Because of the distinguished physical and biological properties, carbon ion radiotherapy (CIRT) has become a unique research focus around the world.…”

Section: Introductionmentioning

confidence: 99%

A preliminary Monte Carlo study for the treatment head of a carbon-ion radiotherapy facility using TOPAS

et al. 2017

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Abstract. In medical physics it is desirable to have a Monte Carlo code that is less complex, reliable yet flexible for dose verification, optimization, and component design. TOPAS is a newly developed Monte Carlo simulation tool which combines extensive radiation physics libraries available in Geant4 code, easyto-use geometry and support for visualization. Although TOPAS has been widely tested and verified in simulations of proton therapy, there has been no reported application for carbon ion therapy. To evaluate the feasibility and accuracy of TOPAS simulations for carbon ion therapy, a licensed TOPAS code (version 3_0_p1) was used to carry out a dosimetric study of therapeutic carbon ions. Results of depth dose profile based on different physics models have been obtained and compared with the measurements. It is found that the G4QMD model is at least as accurate as the TOPAS default BIC physics model for carbon ions, but when the energy is increased to relatively high levels such as 400 MeV/u, the G4QMD model shows preferable performance. Also, simulations of special components used in the treatment head at the Institute of Modern Physics facility was conducted to investigate the Spread-Out dose distribution in water. The physical dose in water of SOBP was found to be consistent with the aim of the 6 cm ridge filter.

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Overview of clinical experiences on carbon ion radiotherapy at NIRS

Cited by 205 publications

References 19 publications

Synergistic growth suppression induced in esophageal squamous cell carcinoma cells by combined treatment with docetaxel and heavy carbon-ion beam irradiation

Synergistic growth suppression induced in esophageal squamous cell carcinoma cells by combined treatment with docetaxel and heavy carbon-ion beam irradiation

Killing of Feline T-Lymphocytes by Gamma-Rays and Energetic Carbon Ions

A preliminary Monte Carlo study for the treatment head of a carbon-ion radiotherapy facility using TOPAS

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