Overview of Candida albicans and Human Papillomavirus (HPV) Infection Agents and their Biomolecular Mechanisms in Promoting Oral Cancer in Pediatric Patients

Muzio, Lorenzo Lo; Ballini, Andrea; Cantore, Stefania; Bottalico, Lucrezia; Charitos, Ioannis Alexandros; Ambrosino, Mariateresa; Nocini, Riccardo; Malcangi, A; Dioguardi, Mario; Cazzolla, Angela Pia; Brauner, Edoardo; Santacroce, Luigì; Cosola, Michele Di

doi:10.1155/2021/7312611

Cited by 29 publications

(40 citation statements)

References 95 publications

(136 reference statements)

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“…Recent reports have documented changes in the diversity of the oral microbiota of HPV-infected individuals [ 191 ] and changes in the overall microbial community and bacterial abundance among HPV-positive OPC patients [ 192 , 193 ]. There have also been reports on the involvement of Candida albicans in carcinogenesis [ 194 ]. These observations suggest that the pathological progression caused by HPV infection may be due to the local environment caused by functional differences in the microbiota.…”

Section: Hpvmentioning

confidence: 99%

Role of Microbiota in Viral Infections and Pathological Progression

Mizutani

Ishizaka

Koga

et al. 2022

Viruses

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Viral infections are influenced by various microorganisms in the environment surrounding the target tissue, and the correlation between the type and balance of commensal microbiota is the key to establishment of the infection and pathogenicity. Some commensal microorganisms are known to resist or promote viral infection, while others are involved in pathogenicity. It is also becoming evident that the profile of the commensal microbiota under normal conditions influences the progression of viral diseases. Thus, to understand the pathogenesis underlying viral infections, it is important to elucidate the interactions among viruses, target tissues, and the surrounding environment, including the commensal microbiota, which should have different relationships with each virus. In this review, we outline the role of microorganisms in viral infections. Particularly, we focus on gaining an in-depth understanding of the correlations among viral infections, target tissues, and the surrounding environment, including the commensal microbiota and the gut virome, and discussing the impact of changes in the microbiota (dysbiosis) on the pathological progression of viral infections.

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Section: Hpvmentioning

confidence: 99%

Role of Microbiota in Viral Infections and Pathological Progression

Mizutani

Ishizaka

Koga

et al. 2022

Viruses

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“…The most important risk factors for the development of oral cancer are tobacco and alcohol use, and it is estimated that approximately 80% of oral cancers occur due to these factors [ 7 , 8 ]. Other risk factors have been identified concomitantly with other pathologies, such as the presence of oral precancerous diseases (leukoplakia, erythroplakia, and lichen planus) and infectious agents (HPV, HCV, and EBV) [ 9 , 10 , 11 , 12 ]. Moreover, traumatic events may contribute to the pathogenesis of oral cancer, along with nutritional factors, genetic factors, ultraviolet radiation, and immunosuppression [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-21 Expression as a Prognostic Biomarker in Oral Cancer: Systematic Review and Meta-Analysis

Dioguardi

Spirito

Sovereto

et al. 2022

IJERPH

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Oral carcinoma represents one of the main carcinomas of the head and neck region, with a 5-year survival rate of less than 50%. Smoking and tobacco use are recognized risk factors. Prognostic survival biomarkers can be a valid tool for assessing a patient’s life expectancy and directing therapy towards specific targets. Among the biomarkers, the alteration of miR-21 expression in tumor tissues is increasingly reported as a valid prognostic biomarker of survival for oral cancer. The purpose of this meta-analysis was, therefore, to investigate and summarize the results in the literature concerning the potential prognostic expression of tissue miR-21 in patients with OSCC. Methods: The systematic review was conducted following the PRISMA guidelines using electronic databases, such as PubMed, Scopus, and the Cochrane Central Register of Controlled Trials, with the use of combinations of keywords, such as miR-21 AND oral cancer, microRNA AND oral cancer, and miR-21. The meta-analysis was performed using the RevMan 5.41 software. Results: At the end of the article-selection process, 10 studies were included in the meta-analysis, and the result for the main outcome was a pooled HR per overall survival (OS) of 1.29 (1.16–1.44) between high and low expression of miR-21. Conclusions: The data in the literature and the results emerging from the systematic review indicate that miR-21 can provide a prognostic indication in oral cancer.

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“…Topical nasal rinses take advantage of this secretory lining in multiple ways. First, nasal rinses physically disrupt the viscous surface layer, removing the mucus and its associated particulate matter [16], [17], [18], [19], [20], [21], [22]. In addition, the presence of nasal saline is hypothesized to function by thinning mucous, improving mucociliary clearance, decreasing edema, and reducing antigen load in the nasal and sinus cavities.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of a Non-addictive Nasal Irrigation Based on Sea Salt Enriched with Natural Enzymes among Patients with Sinusitis: An In Vivo, Randomized, Controlled Trial

Nocini

Cosola

Cazzolla

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: Chronic rhinosinusitis (CRS) is a common condition that is defined as inflammation of the nose and paranasal sinuses. Nasal irrigation plays an important role in the treatment of CRS. Evidence from basic research favors hypertonic saline over isotonic saline for mucociliary clearance, but evidence from clinical studies is controversial. AIM: This study aims to investigate the hypothesis that the use of daily nasal irrigation based on sea salt, enriched with natural enzymes and lysozyme, may be useful in patients with CRS. PATIENT AND METHODS: Patients (30 men and 30 women) 18–55 years old (mean age 41 ± 3 y.o.), with two episodes of acute sinusitis or one episode of chronic sinusitis per year for 2 consecutive years, were enrolled stratified by sex and age and randomly divided into two groups supplementation: Group A (test) and Group B (control/placebo). Moreover, an exit questionnaire was asked to Group A subjects to report whether their sinus-related quality of life has gotten worse, stayed the same, or improved (scale from 0 to ±100%). RESULTS: The result showed that in the test group (A) from T0 to T1, a reduction of 17.65% for the symptoms related headache and/or facial pressure and a reduction of the 18.18%, for the symptoms relates to congestion and/or nasal discharge. On the other hand, the control group (B) shown less difference between T0 and T1. CONCLUSIONS: This study strengthens the argument that the tested formulation is a safe, well-tolerated, long-term therapy that patients with chronic sinonasal complaints can and will use at home with minimal training and follow-up.

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Overview of Candida albicans and Human Papillomavirus (HPV) Infection Agents and their Biomolecular Mechanisms in Promoting Oral Cancer in Pediatric Patients

Cited by 29 publications

References 95 publications

Role of Microbiota in Viral Infections and Pathological Progression

Role of Microbiota in Viral Infections and Pathological Progression

MicroRNA-21 Expression as a Prognostic Biomarker in Oral Cancer: Systematic Review and Meta-Analysis

Efficacy of a Non-addictive Nasal Irrigation Based on Sea Salt Enriched with Natural Enzymes among Patients with Sinusitis: An In Vivo, Randomized, Controlled Trial

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