Overview of Caffeine Effects on Human Health and Emerging Delivery Strategies

Saraiva, Sofia M.; Jacinto, Telma A.; Gonçalves, Ana C.; Gaspar, Dário; Silva, Luís

doi:10.3390/ph16081067

Cited by 11 publications

(4 citation statements)

References 201 publications

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“…Intriguingly, caffeine metabolism has been implicated in frailty. Caffeine is known for its antioxidant, anti-inflammatory, and anti-aging effects, and its beneficial impacts on diseases like CVD ( Saraiva et al, 2023 ). A population-based study revealed a nonlinear association between caffeinated coffee consumption and reduced frailty, especially among non-smokers ( Pang et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Metabolic clues to aging: exploring the role of circulating metabolites in frailty, sarcopenia and vascular aging related traits and diseases

Qian,

Huang,

Zhang

et al. 2024

Front. Genet.

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Background: Physical weakness and cardiovascular risk increase significantly with age, but the underlying biological mechanisms remain largely unknown. This study aims to reveal the causal effect of circulating metabolites on frailty, sarcopenia and vascular aging related traits and diseases through a two-sample Mendelian Randomization (MR) analysis.Methods: Exposures were 486 metabolites analyzed in a genome-wide association study (GWAS), while outcomes included frailty, sarcopenia, arterial stiffness, atherosclerosis, peripheral vascular disease (PAD) and aortic aneurysm. Primary causal estimates were calculated using the inverse-variance weighted (IVW) method. Methods including MR Egger, weighted median, Q-test, and leave-one-out analysis were used for the sensitive analysis.Results: A total of 125 suggestive causative associations between metabolites and outcomes were identified. Seven strong causal links were ultimately identified between six metabolites (kynurenine, pentadecanoate (15:0), 1-arachidonoylglycerophosphocholine, androsterone sulfate, glycine and mannose) and three diseases (sarcopenia, PAD and atherosclerosis). Besides, metabolic pathway analysis identified 13 significant metabolic pathways in 6 age-related diseases. Furthermore, the metabolite-gene interaction networks were constructed.Conclusion: Our research suggested new evidence of the relationship between identified metabolites and 6 age-related diseases, which may hold promise as valuable biomarkers.

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Section: Discussionmentioning

confidence: 99%

Metabolic clues to aging: exploring the role of circulating metabolites in frailty, sarcopenia and vascular aging related traits and diseases

Qian,

Huang,

Zhang

et al. 2024

Front. Genet.

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“…Caffeine acts as a stimulant, antioxidant, anti-inflammatory, and even an aid in pain management, and is found in several over-the-counter medications. Currently, caffeine’s effect on cancer and cardiovascular, immunological, inflammatory, and neurological diseases is intensively studied [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Caffeine on the Inflammatory-Dependent Changes in the GnRH/LH Secretion in a Female Sheep Model

Herman,

Tomczyk,

Wójcik

et al. 2024

IJMS

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Caffeine is one of the most widely consumed psychoactive drugs in the world. It easily crosses the blood–brain barrier, and caffeine-interacting adenosine and ryanodine receptors are distributed in various areas of the brain, including the hypothalamus and pituitary. Caffeine intake may have an impact on reproductive and immune function. Therefore, in the present study performed on the ewe model, we decided to investigate the effect of peripheral administration of caffeine (30 mg/kg) on the secretory activity of the hypothalamic–pituitary unit which regulates the reproductive function in females during both a physiological state and an immune/inflammatory challenge induced by lipopolysaccharide (LPS; 400 ng/kg) injection. It was found that caffeine stimulated (p < 0.01) the biosynthesis of gonadotropin-releasing hormone (GnRH) in the hypothalamus of ewe under both physiological and inflammatory conditions. Caffeine also increased (p < 0.05) luteinizing hormone (LH) secretion in ewes in a physiological state; however, a single administration of caffeine failed to completely release the LH secretion from the inhibitory influence of inflammation. This could result from the decreased expression of GnRHR in the pituitary and it may also be associated with the changes in the concentration of neurotransmitters in the median eminence (ME) where GnRH neuron terminals are located. Caffeine and LPS increased (p < 0.05) dopamine in the ME which may explain the inhibition of GnRH release. Caffeine treatment also increased (p < 0.01) cortisol release, and this stimulatory effect was particularly evident in sheep under immunological stress. Our studies suggest that caffeine affects the secretory activity of the hypothalamic–pituitary unit, although its effect appears to be partially dependent on the animal’s immune status.

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“…Indeed, xanthines have been recognized as therapeutically potent compounds for the treatment of various diseases [4] and are effective in the treatment of neurodegenerative and respiratory diseases, diabetes and cancer [5] .The most widely known methylxanthine is caffeine, which can be found in coffee, tea, cocoa, cola and other beverages and foods, being the most consumed psychostimulant worldwide [6] . Caffeine is used therapeutically to treat various headache conditions and respiratory depression in neonates, among other conditions [7,8] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Medicinal Applications of N-Heterocyclic Carbene Complexes Based on Caffeine and Other Xanthines

Petronilho,

Francescato,

Leitao

et al. 2024

Preprint

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Xanthines are purine derivatives predominantly found in plants. Xanthines include compounds such as caffeine, theophylline, and theobromine and exhibit a variety of pharmacological properties, demonstrating efficacy in treating neurodegenerative disorders, respiratory dysfunctions, and also in cancer. The versatile attributes of these materials render them privileged scaffolds for the development of compounds for various biological applications. Xanthines are N-heterocyclic carbene precursors that combine a pyrimidine and an imidazole ring. Owing to their biological relevance, xanthines have been employed as N-heterocyclic carbenes in the development of metallodrugs for anticancer and antimicrobial purposes. In this conceptual review, we examine key examples of N-heterocyclic carbene complexes derived from caffeine and other xanthines, elucidating their synthetic methods and describing their pertinent medicinal applications.

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Overview of Caffeine Effects on Human Health and Emerging Delivery Strategies

Cited by 11 publications

References 201 publications

Metabolic clues to aging: exploring the role of circulating metabolites in frailty, sarcopenia and vascular aging related traits and diseases

Metabolic clues to aging: exploring the role of circulating metabolites in frailty, sarcopenia and vascular aging related traits and diseases

Effect of Caffeine on the Inflammatory-Dependent Changes in the GnRH/LH Secretion in a Female Sheep Model

Synthesis and Medicinal Applications of N-Heterocyclic Carbene Complexes Based on Caffeine and Other Xanthines

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