Overview of Biologic Agents Used in Skin and Soft Tissue Reconstruction

Parham, Matthew J.; Grush, Andrew E.; Smerica, Abel M; Wen, Yuan Edward; Depani, Monal; Ferry, Andrew M.; Jones, Lloyd M.; Thornton, James F.

doi:10.1055/s-0042-1742736

Cited by 2 publications

(2 citation statements)

References 52 publications

(67 reference statements)

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“… 15 Various expensive skin substitutes and wound dressings have also been developed; however, their effectiveness is currently limited. 16 NPWT with instillation and dwelling, which has the additional function of continuous wound cleansing, is gradually becoming more available. 17 This also has significant healthcare economic disadvantages.…”

Section: Discussionmentioning

confidence: 99%

A novel intervention for wound bed preparation in severe extremity trauma: Highly concentrated carbon dioxide bathing

Hihara,

Himejima,

Takeji

et al. 2024

JPRAS Open

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Section: Discussionmentioning

confidence: 99%

A novel intervention for wound bed preparation in severe extremity trauma: Highly concentrated carbon dioxide bathing

Hihara,

Himejima,

Takeji

et al. 2024

JPRAS Open

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“…Although their indications for use have substantially broadened, biologic wound treatments were traditionally used in burn and abdominal wall restoration [43]. Several dermoinductive and dermoconductive wound agents have currently been approved by the United States Food and Drug Association (FDA) for the purpose of soft tissue reconstruction; nevertheless, many reconstructive surgeons use them off-label to fix defects not explicitly permitted by the FDA [44].…”

Section: Applicationsmentioning

confidence: 99%

Skin Substitutes and Biologic Agents for Wound Closures after Melanoma Resection

Depani¹,

Thornton²

2023

Melanoma - Standard of Care, Challenges, and Updates in Clinical Research

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Wound healing is a highly complex process mediated by microscopic cellular interactions. An improved understanding of the physiology of wound healing has laid the groundwork for translational research to create biologic wound care technologies that have significantly impacted patient care. Biologic wound technologies have broad applications and have had a significant impact on the reconstructive ladder, as the reader will see throughout this chapter. Despite their frequent use, many surgeons are unfamiliar with the plethora of products on the market, as well as each product’s relative advantages and disadvantages. This chapter will go over oncologic reconstruction of the nose, scalp, lip, cheek, and extremities after wide local excision of melanomas in these areas, which is a significant challenge for plastic surgeons. Traditional methods for reconstructing these defects include primary closure techniques, skin grafts, local flaps, pedicled flaps, and free tissue transfer; however, the increased risk of metastasis associated with melanoma makes it difficult to use biologic wound healing agents like Integra and Cytal as alternative reconstructive options without causing additional donor site morbidity. In this chapter, we examine the use of biological agents in soft tissue reconstruction, including the surgical approaches, complications, and limitations of various reconstructive methods.

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Overview of Biologic Agents Used in Skin and Soft Tissue Reconstruction

Cited by 2 publications

References 52 publications

A novel intervention for wound bed preparation in severe extremity trauma: Highly concentrated carbon dioxide bathing

A novel intervention for wound bed preparation in severe extremity trauma: Highly concentrated carbon dioxide bathing

Skin Substitutes and Biologic Agents for Wound Closures after Melanoma Resection

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