Overview: N-Nitroso Compounds as Carcinogens for Experimental Animals and Man

Odashima, Shigeyoshi

doi:10.1159/000225453

Cited by 17 publications

(8 citation statements)

References 9 publications

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“…Processed meat contains nitrates and nitrites and is a major source of N-nitroso compounds (NOCs) and NOC precursors [20]. Nitrites or nitrates (e.g., sodium nitrite) added to meat for preservation can also form NOCs endogenously in animals and humans, and NOCs have been proved to be carcinogenic [21, 22]. Nitrites and nitrates from processed meat intake have been shown to increase the risk of colorectal adenoma, and higher level of intake of nitrite and nitrate was associated with an increased risk of colorectal adenoma compared with no or low level of intake [23].…”

Section: Discussionmentioning

confidence: 99%

A Case-Control Study of Risk Factors for Salivary Gland Cancer in Canada

Pan

Groh

Morrison

2017

Journal of Cancer Epidemiology

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Aim. To assess the effect of various lifestyle risk factors on the risk of salivary gland cancer in Canada using data from a population-based case-control study. Methods. Data from a population-based case-control study of 132 incident cases of salivary gland cancer and 3076 population controls were collected through self-administered questionnaire and analysed using unconditional logistic regression. Results. Four or more servings/week of processed meat product was associated with an adjusted odds ratio (OR) and corresponding 95% confidence interval (CI) of 1.62 (1.02–2.58). Nonsignificantly increased ORs were also related to obesity, >7 drinks/week of alcohol consumption, and occupational exposure to radiation. Furthermore, nonsignificantly decreased ORs were found to be associated with high education level (>12 years) (OR = 0.65), high consumption of spinach/squash (OR = 0.62) and all vegetables/vegetable juices (OR = 0.75), and >30 sessions/month of recreational physical activity (OR = 0.78). Conclusions. This study suggests positive associations with consumption of processed meat, smoking, obesity, alcohol drinking, and occupational exposure to radiation as well as negative associations with higher education, consumption of spinach/squash, and physical activity, which suggest a role of lifestyle factors in the etiology of salivary gland cancer. However, these findings were based on small number of cases and were nonsignificant. Further larger studies are warranted to confirm our findings.

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Section: Discussionmentioning

confidence: 99%

A Case-Control Study of Risk Factors for Salivary Gland Cancer in Canada

Pan

Groh

Morrison

2017

Journal of Cancer Epidemiology

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“…Because of its role in ecosystem dynamics and its potential impact on human health (2,3), nitrate levels in water are regulated and carefully monitored in engineered and environmental systems. There are many methods for measuring aqueous nitrate concentrations, including spectroscopic (4)(5)(6), chromatographic (7), and electrochemical (8,9) techniques.…”

Section: Nitrate (Nomentioning

confidence: 99%

A Sensitive Nitrate Ion-Selective Electrode from a Pencil Lead. An Analytical Laboratory Experiment

Bendikov

Harmon

2005

J. Chem. Educ.

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Nitrate ion is an important environmental and human health analyte and thus its detection and quantification is considered essential. This article summarizes a simple procedure for preparing and testing a nitrate ion-selective electrode based on doped polypyrrole films. Everyday pencil leads were used as a substrate for the electrochemical deposition of polypyrrole. Nitrate-doped polypyrrole electrodes, tested potentiometrically for their response to varying NO3 –concentrations, exhibited Nernstian behavior (slopes of 54–55 mV per log cycle of nitrate concentration at T = 22°C), with a linear response to nitrate concentrations spanning three orders of magnitude (0.1–1× 10–4 M of NO3 –) and a detection limit of 5 ± 1 × 10–5 M of nitrate. The procedure outlined here has the potential to initiate and motivate students with interests in sensor development, micro-fabrication procedures, advanced monitoring of environmental problems, and creating solutions to those problems.

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“…For example, excessive amounts of nitrite typically used for food preservation have been proved to be carcinogenic, teratogenic, or mutagenic because nitrite reacts with amines and results in the formation of N-nitroso compounds. [38][39][40] Nitrites irreversibly react with oxyhemoglobin to produce methemoglobin in the bloodstream, thereby interfering with oxygen transport in the blood and causing a condition called methemoglobinemia. 41 The nitrite ion is also of interest as a nitric oxide metabolite in numerous physiological processes related to neurotransmission, vasodilatation, inammation, cell proliferation, and apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Nitrite ion-induced fluorescence quenching of luminescent BSA-Au₂₅nanoclusters: mechanism and application

Unnikrishnan

Wei

Chiu

et al. 2014

Analyst

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Fluorescence quenching is an interesting phenomenon which is highly useful in developing fluorescence based sensors. A thorough understanding of the fluorescence quenching mechanism is essential to develop efficient sensors. In this work, we investigate different aspects governing the nitrite ion-induced fluorescence quenching of luminescent bovine serum albumin stabilized gold nanoclusters (BSA-Au NCs) and their application for detection of nitrite in urine. The probable events leading to photoluminescence (PL) quenching by nitrite ions were discussed on the basis of the results obtained from ultraviolet-visible (UV-Vis) absorption spectroscopy, X-ray photoelectron spectroscopy (XPS), fluorescence measurements, circular dichroism (CD) spectroscopy, zeta potential and dynamic light scattering (DLS) studies. These studies suggested that PL quenching mainly occurred through the oxidation of Au(0) atoms to Au(i) atoms in the core of BSA-Au NCs mediated by nitrite ions. The interference caused by certain species such as Hg(2+), Cu(2+), CN(-), S(2-), glutathione, cysteine, etc. during the nitrite determination by fluorescence quenching was eliminated by using masking agents and optimising the conditions. Based on these findings we proposed a BSA-Au NC-modified membrane based sensor which would be more convenient for the real life applications such as nitrite detection in urine samples. The BSA-Au NC-modified nitrocellulose membrane (NCM) enabled the detection of nitrite at a level as low as 100 nM in aqueous solutions. This Au NC-based paper probe was validated to exhibit good performance for nitrite analysis in environmental water and urine samples, which makes it useful in practical applications.

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Overview: N-Nitroso Compounds as Carcinogens for Experimental Animals and Man

Cited by 17 publications

References 9 publications

A Case-Control Study of Risk Factors for Salivary Gland Cancer in Canada

A Case-Control Study of Risk Factors for Salivary Gland Cancer in Canada

A Sensitive Nitrate Ion-Selective Electrode from a Pencil Lead. An Analytical Laboratory Experiment

Nitrite ion-induced fluorescence quenching of luminescent BSA-Au₂₅nanoclusters: mechanism and application

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Overview: N-Nitroso Compounds as Carcinogens for Experimental Animals and Man

Cited by 17 publications

References 9 publications

A Case-Control Study of Risk Factors for Salivary Gland Cancer in Canada

A Case-Control Study of Risk Factors for Salivary Gland Cancer in Canada

A Sensitive Nitrate Ion-Selective Electrode from a Pencil Lead. An Analytical Laboratory Experiment

Nitrite ion-induced fluorescence quenching of luminescent BSA-Au25nanoclusters: mechanism and application

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Nitrite ion-induced fluorescence quenching of luminescent BSA-Au₂₅nanoclusters: mechanism and application