Overview for Pattern and Results of Herbal Medicine-derived Atopic Dermatitis Clinical Researches

Abstract

ObjectivesTo make comprehensive feature of clinical trials using herbal medicine and their results by today, then help a strategy for herbal medication-derived clinical studies in the future. MethodsThrough medical website (Pubmed․EBSCO․Medline), foreign clinical literatures about atopic dermatitis and herbal medicine were searched. And domestic clinical literatures about atopic dermatitis using internet website (OASIS) and hand-searching. Analysis was performed according to distribution mainly by subject, study design, number by year and its efficacy. Results and ConclusionsSeventy-nine (Domestic literatures: Fifty, Foreign literatures: Twenty-nine) literatures were selected according to inclusion criteria of clinical study. 80% of domestic clinical literatures were observational studies, 50% of foreign were intervention. There were six adverse effect case studies, two follow-ups, one case report, four translational and four uncontrolled clinical trials in foreign literatures. And nineteen case reports, eighteen case series, two follow-up and five uncontrolled clinical studies in domestic. Six RCTs have established by four external herb therapy and two decoctions in Korea, showed positive effects. Three out of four external applications RCTs, four out of seven decoctions showed positive results in foreign studies. This study revealed the current status of atopic dermatitis clinical research using herbal drugs. To put clinical trials to use of herbal medicine in the treatment atopic dermatitis, scientific and objective-based studies should be needed.

Retrospective Study about the Effectiveness of a long-term Korean Medicine Treatment on 511 Atopic Dermatitis Patients

“…또한 증례 보고를 넘 어선 특정 처방 및 한방 외용제의 효과에 대한 연구 도 이루어지고 있다 6) . 국내와 국외 모두 RCT 연구가 증가하는 등 양적, 질적으로 향상된 연구가 늘어나고 있으며 대규모 연구는 대부분 국외에서 이루어지고 있다 [7][8][9][10][11][12] . (Table 3).…”