Overview and recent advances in PET/CT imaging in lymphoma and multiple myeloma

Zanoni, Lucia; Mattana, Francesco; Calabrò, Diletta; Paccagnella, Andrea; Broccoli, Alessandro; Nanni, Cristina; Fanti, Stefano

doi:10.1016/j.ejrad.2021.109793

Cited by 18 publications

(12 citation statements)

References 118 publications

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“…FDG-PET/CT is most frequently employed for diagnosing and staging cancer, monitoring response to treatment, and detecting recurrence in various malignancies [ 55 ]. For these patients, and others who are already undergoing this modality, FDG-PET/CT imaging can provide vital information at the cellular level and may allow for the earliest detection of asymptomatic COVID-19 infection [ 5 , 38 , 46 – 51 , 56 , 57 ].…”

Section: Fdg-petmentioning

confidence: 99%

The value of FDG-PET/CT imaging in the assessment, monitoring, and management of COVID-19

et al. 2023

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The pathogenesis of Coronavirus Disease 2019 (COVID-19) involves cytokine-driven recruitment and accumulation of inflammatory cells at sites of infection. These activated neutrophils, monocytes, and effector T cells are highly glycolytic and thus appear as [18]F-labeled fluorodeoxyglucose (FDG) avid sites on positron emission tomography (PET) imaging. FDG-PET-computed tomography (FDG-PET/CT) is a highly sensitive modality for the detection, monitoring, and assessing response related to COVID-19 disease activity that holds significant clinical relevance. To date, concerns over cost, access, and undue radiation exposure have limited the use of FDG-PET/CT in COVID-19 to a small number of individuals where PET-based interventions were already indicated. In this review, we summarize the existing literature on the use of FDG-PET in the detection and monitoring of COVID-19 with particular focus on several areas of clinical relevance that warrant future research: (1) incidental early detection of subclinical COVID-19 in patients who have undergone FDG-PET for other underlying diseases, (2) standardized quantitative assessment of COVID-19 disease burden at specific points in time, and (3) analysis of FDG-PET/CT data leading to better characterization of COVID-19 pathogenesis. Employing FDG-PET/CT for these purposes may allow for the earliest detection of COVID-19-associated venous thromboembolism (VTE), standardized monitoring of disease progression and response to treatment, and better characterization of the acute and chronic complications of this disease.

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Section: Fdg-petmentioning

confidence: 99%

The value of FDG-PET/CT imaging in the assessment, monitoring, and management of COVID-19

et al. 2023

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“…18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) is currently essential for accurate staging and for early and late therapy response assessment. The widely adopted visual Deauville 5-point scale and Lugano Classification recommendations have recently standardized PET scans interpretation and allowed improvement in the management of lymphoma patients [5]. The CT as part of a PET-CT scan may be performed with contrast enhancement (ceCT) at full dose to obtain high quality images, or without contrast using a lower dose.…”

Section: Introductionmentioning

confidence: 99%

“…Contrast-enhanced CT is also preferred for radiation planning. Variably FDG-avid histologies should be staged with CT [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Computed Tomography Structured Reporting in the Staging of Lymphoma: A Delphi Consensus Proposal

Granata

Pradella

Cozzi

et al. 2021

JCM

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Structured reporting (SR) in radiology is becoming increasingly necessary and has been recognized recently by major scientific societies. This study aims to build structured CT-based reports for lymphoma patients during the staging phase to improve communication between radiologists, members of multidisciplinary teams, and patients. A panel of expert radiologists, members of the Italian Society of Medical and Interventional Radiology (SIRM), was established. A modified Delphi process was used to develop the SR and to assess a level of agreement for all report sections. The Cronbach’s alpha (Cα) correlation coefficient was used to assess internal consistency for each section and to measure quality analysis according to the average inter-item correlation. The final SR version was divided into four sections: (a) Patient Clinical Data, (b) Clinical Evaluation, (c) Imaging Protocol, and (d) Report, including n = 13 items in the “Patient Clinical Data” section, n = 8 items in the “Clinical Evaluation” section, n = 9 items in the “Imaging Protocol” section, and n = 32 items in the “Report” section. Overall, 62 items were included in the final version of the SR. A dedicated section of significant images was added as part of the report. In the first Delphi round, all sections received more than a good rating (≥3). The overall mean score of the experts and the sum of score for structured report were 4.4 (range 1–5) and 1524 (mean value of 101.6 and standard deviation of 11.8). The Cα correlation coefficient was 0.89 in the first round. In the second Delphi round, all sections received more than an excellent rating (≥4). The overall mean score of the experts and the sum of scores for structured report were 4.9 (range 3–5) and 1694 (mean value of 112.9 and standard deviation of 4.0). The Cα correlation coefficient was 0.87 in this round. The highest overall means value, highest sum of scores of the panelists, and smallest standard deviation values of the evaluations in this round reflect the increase of the internal consistency and agreement among experts in the second round compared to first round. The accurate statement of imaging data given to referring physicians is critical for patient care; the information contained affects both the decision-making process and the subsequent treatment. The radiology report is the most important source of clinical imaging information. It conveys critical information about the patient’s health and the radiologist’s interpretation of medical findings. It also communicates information to the referring physicians and records this information for future clinical and research use. The present SR was generated based on a multi-round consensus-building Delphi exercise and uses standardized terminology and structures, in order to adhere to diagnostic/therapeutic recommendations and facilitate enrolment in clinical trials, to reduce any ambiguity that may arise from non-conventional language, and to enable better communication between radiologists and clinicians.

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“…1,2 However, survivors of pediatric HL are at high risk of potentially life-limiting second cancers related to the radiation doses and fields: impaired fertility, especially in boys secondary to cumulative doses of alkylating agents, and treatment-associated cardiovascular diseases. 1,2 For this reason, the goal of a risk-adapted therapy is to minimize toxicities and maximize disease control. To this end, a functional imaging with 18 fluorinefluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) is fundamental.…”

mentioning

confidence: 99%

“…HL is one of the most curable pediatric cancers with long-term survival rates exceeding 90% following treatment with chemotherapy alone or in combination with radiotherapy. 1,2 However, survivors of pediatric HL are at high risk of potentially life-limiting second cancers related to the radiation doses and fields: impaired fertility, especially in boys secondary to cumulative doses of alkylating agents, and treatment-associated cardiovascular diseases. 1,2 For this reason, the goal of a risk-adapted therapy is to minimize toxicities and maximize disease control.…”

mentioning

confidence: 99%

Metabolic tumor volume as prognostic factor in pediatric Hodgkin lymphoma: Dream or reality?

Albano

2021

Pediatric Blood & Cancer

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Overview and recent advances in PET/CT imaging in lymphoma and multiple myeloma

Cited by 18 publications

References 118 publications

The value of FDG-PET/CT imaging in the assessment, monitoring, and management of COVID-19

The value of FDG-PET/CT imaging in the assessment, monitoring, and management of COVID-19

Computed Tomography Structured Reporting in the Staging of Lymphoma: A Delphi Consensus Proposal

Metabolic tumor volume as prognostic factor in pediatric Hodgkin lymphoma: Dream or reality?

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