Overview and guidelines of off-label use of methotrexate in ectopic pregnancy: report by CNGOF

Predicting success of methotrexate treatment by pretreatment HCG level and 24‐hour HCG increment

“…The present negative predictive value of 100% for β‐HCG levels above 4000 IU/L is lower than the threshold reported by Menon et al., who stated that the failure rate rises above 5000 IU/L. Marret et al . noted the same value of 5000 IU/L as an upper limit for methotrexate treatment (in any regimen).…”

Hysteroscopic treatment of cervical pregnancy: case report

“…5 Previously, evacuation was performed with instrumented uterine curettage, causing incoercible bleeding, which required to be controlled with different methods such as tamponade, cerclages or impingement, with unsatisfactory results that concluded in surgical treatment with hysterectomy. [6][7][8] Heredofamilial history without relevance for the condition, blood group O positive, chronic degenerative diseases and allergies denied, appendectomy open at 10 years, menarche at 12 years with regular cycles at the rate of 28 × 3 days, onset of sexual life at 15 years, number of sexual partners: 7, family planning method: condom, one pregnancy. Go to the emergency department in a second level unit, with little transvaginal bleeding not corresponding to your period, with amenorrhea of 5 weeks, without abdominal pain.…”

Early predictive factors of single dose methotrexate outcome in patients with ectopic pregnancy

“…However, high-quality data comparing the efficacy of single dose MTX treatment according to MTX dosage are still lacking. Hence, recent French guidelines have recommended the use of both dosages [3].…”