Overview and Analysis of the Cost of Drug Programs in Poland: Public Payer Expenditures and Coverage of Cancer and Non-Neoplastic Diseases Related Drug Therapies from 2015–2018 Years

Mela, Aneta; Poniatowski, Łukasz A.; Drop, Bartłomiej; Furtak–Niczyporuk, Marzena; Jaroszyński, J; Wrona, W; Staniszewska, Anna; Dąbrowski, Jan; Czajka, Anna; Jagielska, Beata; Wojciechowska, Monika; Niewada, Maciej

doi:10.3389/fphar.2020.01123

Cited by 22 publications

(18 citation statements)

References 8 publications

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“…The early implementation of palliative care is requested by the reduced cognitive ability of brain tumor patients [ 9 ] and by the heavy distress that is experienced by caregivers. Moreover, in the context of the heavy socioeconomic burden of cancer [ 10 , 11 ], it has been shown that early palliative care activation reduces the costs of hospitalizations [ 12 ] and leads to an increase in home discharge for end-of-life care [ 13 ]. In most of the cases discussed here, caregivers had to face a sudden worsening of patients’ neurological conditions without having the possibility to set up adequate domestic assistance: this can explain the low rate of home deaths in our series.…”

Section: Discussionmentioning

confidence: 99%

Neurosurgical Defeats: Critically Ill Patients and the Role of Palliative Care Service

D’Alessandris

Ricciotti

Palombi

et al. 2022

JPM

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The onco-functional balance in neuro-oncology requires maximizing tumor removal while rigorously preserving patients’ neurological status. When postoperative worsening prevents the implementation of oncologic treatments, palliative care service offers an individualized path for symptom and psychosocial distress relief. Here, we report on a series of 25 patients operated on for malignant brain tumor who did not undergo adjuvant treatments after neurosurgery; they represented 3.9% of the whole institutional surgical series. These patients were significantly older and had a lower preoperative Karnofsky performance status than the whole cohort. Importantly, in 22 out of 25 (88%) cases, a surgical complication occurred, leading to clinical worsening in 21 patients. For the end of life, the majority of patients chose a hospice care facility (72%). While a careful selection of brain tumor patients candidate to neurosurgery is required, palliative care service provided invaluable help in coping with patients’ and caregivers’ needs.

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Section: Discussionmentioning

confidence: 99%

Neurosurgical Defeats: Critically Ill Patients and the Role of Palliative Care Service

D’Alessandris

Ricciotti

Palombi

et al. 2022

JPM

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“…Breast cancer (BC) is the most common cancer, accounting for 11.7% of all new diagnoses in 2020, and is responsible for 7% of all cancer-related deaths [1] . As such, breast cancer is a serious public health concern and can be responsible for considerable costs in healthcare services [2] .…”

Section: Introductionmentioning

confidence: 99%

The safety and efficacy of palbociclib in older patients with advanced breast cancer in a real-world setting

Gouton¹,

Louis²,

Micallef³

et al. 2022

J Cancer Metastasis Treat

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Aims: Palbociclib has been approved in combination with endocrine therapy (ET) for hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC), regardless of age. Even though ABC is one of the most prevalent cancers in older patients, very few patients ≥ 65 years old were included in pivotal trials. Therefore, the current study evaluated the safety and efficacy of palbociclib in “real-world” routine treatment of unselected older patients with HR+/HER2- ABC. Methods: Data were collected on patients > 70 years old who were treated with palbociclib plus ET for HR+/HER2- ABC in our institution. We analyzed safety data (CTCAE v4.0 criteria) and outcomes, such as progression-free survival (PFS) and overall survival (OS), as well as any associations between main geriatric characteristics and our results. Furthermore, we assessed safety at a national level by analyzing all palbociclib-related adverse events (AEs) reported in the French Pharmacovigilance Database (FPVD) during the same period. Results: From February 2016 to July 2019, 52 patients were identified with a median age of 80.9 years, of whom 88% presented an AE. The most common grade 3-4 AE was neutropenia (64%). Median PFS and OS were nine months and not reached, respectively. The FPVD reports 227 cases of palbociclib-related AEs, with older and younger patients sharing similar characteristics. Conclusion: Palbociclib is well tolerated in older patients with efficacy comparable to that in younger patients. However, the addition of palbociclib to ET should be evaluated individually in this older and frailer subgroup.

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“…Excessive alcohol consumption leads to a substantial increase in the number of hospitalization, an increase in social and economic costs and the increase in the prices of alcoholic beverages brings a positive contribution to public health [2,3]. However, a study conducted in 15 Latin American countries tried to make a comparison between the taxes levied on soft drinks and beer.…”

Section: Introductionmentioning

confidence: 99%

Statistical study of changes in motor quality (speed) following a moderate beer consumption

2021

JOMH

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Background and objectives: Beer consumed in moderation (330 mL/day for women and 660 mL/day for men, up to 5% alcohol) may have certain beneﬁts for the human body, due to natural ingredients, but especially due to important sources of protein, ﬁber and antioxidants. According to specialized studies, beer consumed in moderation can have beneﬁcial effects on the body. Materials and methods: The study was conducted on 50 subjects selected based on characteristics such as age, height, weight and not after exercising or doing physical activities. All research subjects beneﬁted from two evaluations (initial and ﬁnal), consisting of: physical examination, EKG examination, body hydration analysis, adipose tissue analysis, muscle tissue analysis, heart rate analysis and speed motor quality. These analyses were performed daily for a period of seven days, both for the initial and the ﬁnal evaluation (a total of 14 days of assessments). Results: Between the two evaluations, subjects consumed 660 mL of beer with up to 5% alcohol daily (WHO recommended dose) for 30 days. The results obtained (at the initial and ﬁnal evaluation) were inventoried and statistically processed using statistical programs. It was found that moderate beer consumption (660 mL of beer with up to 5% alcohol) daily for a period of 30 days can lead to an increase in body hydration, a decrease in adipose tissue as well as an increase in muscle mass. In addition, a decrease in heart rate was observed after physical activity (short running on 100 m), which leads us to a better adaptation of the body after intense physical effort. Discussion and conclusion: Moderate beer consumption (660 mL/day for men, up to 5% alcohol, WHO recommended dose) can have beneﬁcial effects on body hydration, adipose and muscle tissue, and better adaptation of the body after intense physical effort.

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Overview and Analysis of the Cost of Drug Programs in Poland: Public Payer Expenditures and Coverage of Cancer and Non-Neoplastic Diseases Related Drug Therapies from 2015–2018 Years

Cited by 22 publications

References 8 publications

Neurosurgical Defeats: Critically Ill Patients and the Role of Palliative Care Service

Neurosurgical Defeats: Critically Ill Patients and the Role of Palliative Care Service

The safety and efficacy of palbociclib in older patients with advanced breast cancer in a real-world setting

Statistical study of changes in motor quality (speed) following a moderate beer consumption

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