Overuse of acid-suppressive therapy in hospitalized patients

Inadequate Use of Acid-Suppressive Therapy in Hospitalized Patients and Its Implications for General Practice

“…In our study, the prevalence of inappropriate use of acid-suppressive drugs was lower than previously reported (1,2,7). This finding is due only in part to the more suitable definition of appropriateness criteria adopted in our study, in particular, the separation of the "not appropriate" group from the "acceptable" group and the lowering of the threshold patient age for appropriate PPI use to 60 years (1,2,7).…”

“…This finding is due only in part to the more suitable definition of appropriateness criteria adopted in our study, in particular, the separation of the "not appropriate" group from the "acceptable" group and the lowering of the threshold patient age for appropriate PPI use to 60 years (1,2,7). Moreover, our patients were generally older than in previous series, frequently affected by severe comorbidities and treated with ASA for cardiovascular prophylaxis.…”

Effects of pharmacy resident led education on resident physician prescribing habits associated with stress ulcer prophylaxis in non-intensive care unit patients

“…2,3,[6][7][8][9][10][11] Studies report 65-69% of non-ICU patients do not meet criteria for SUP nor have an indication for acid-suppressive therapy. A retrospective analysis (n = 279) found that 204 (73%) patients were prescribed SUP without an appropriate indication, with 140 (69%) patients continuing upon discharge.…”

Clostridium perfringens Spontaneous Bacterial Peritonitis: Report of a Case and Implications for Management

“…Further, the study was not primarily designed to detect such a difference and therefore may lack the statistical power to do so. Given the reported overuse of acid suppressive therapy in hospitalized patients and the rise of direct to consumer advertising of proton pump inhibitors, this potential association could be of substantial clinical relevance (22,23). In light of our patient's case, we propose that a relationship between the two may exist and that investigation of this phenomenon is warranted.…”