“…Several hypotheses have been suggested to explain the pathophysiology of the medial tibial stress syndrome. A local inflammatory reaction at the musculotendinous attachment of the periosteum, 5,9,13,23,24 chronic posterior compartment syndrome, 1,9,26,28 or a microfracture with increased scintigraphic uptake (but no radiological evidence of stress fracture) 9,10,12,27 have all been proposed. Changes in bone signal in the affected region on MRI support the hypothesis that the skeleton is affected in the syndrome.…”