Overproduction of cordycepin in Saccharomyces cerevisiae by cordycepin synthase screening and metabolic engineering
Haibin Wang,
Xiaomeng Fu,
Xiaoru Zuo
et al.
Abstract:Cordycepin (COR) has attracted extensive attention for its medical value. Currently, separation and extraction from Cordyceps militaris is the main way to obtain COR, but it is time‐consuming and low efficiency. Heterologous synthesis of COR holds great promise for its industrial production. In this work, five COR synthases of different sources were obtained by homology screening, and were integrated into the genome of BY4741. Fermentation and determination of COR found that EA1 and EA2 from Emericellopsis atl… Show more
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