Overnutrition during lactation leads to impairment in insulin signaling, up-regulation of GLUT1 and increased mitochondrial carbohydrate oxidation in heart of weaned mice

Bernardo, Amélia Faustino; Cortez, Erika; Neves, Fabiana Alves; Vieira, Anatalia Kutianski Gonzalez; Soares, Vivian de Melo; Rodrigues-Cunha, Alessandra Cordeiro de Souza; Andrade, Daniela Caldas de; Thole, Alessandra Alves; Gabriel-Costa, Daniele; Brum, Patrícia Chakur; Moura, Aníbal Sanchez; Garcia-Souza, Érica Patrícia

doi:10.1016/j.jnutbio.2015.09.021

Cited by 14 publications

(12 citation statements)

References 51 publications

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“…62 More specifically, an increased Bax/Bcl2 ratio has been seen in cardiac fibrosis. 63 Of note, we found a significant increase in the ratio of Bax to Bcl2 (Figure 4F-H), which is indicative for a cellular shift towards a pro-apoptotic phenotype.…”

Section: Aox Improves Mitochondrial Functions 3 Weeks After An Ischmentioning

confidence: 67%

Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia

Szibor

Schreckenberg

Gizatullina

et al. 2020

J Cellular Molecular Medi

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Cardiac ischaemia‐reperfusion (I/R) injury has been attributed to stress signals arising from an impaired mitochondrial electron transport chain (ETC), which include redox imbalance, metabolic stalling and excessive production of reactive oxygen species (ROS). The alternative oxidase (AOX) is a respiratory enzyme, absent in mammals, that accepts electrons from a reduced quinone pool to reduce oxygen to water, thereby restoring electron flux when impaired and, in the process, blunting ROS production. Hence, AOX represents a natural rescue mechanism from respiratory stress. This study aimed to determine how respiratory restoration through xenotopically expressed AOX affects the re‐perfused post‐ischaemic mouse heart. As expected, AOX supports ETC function and attenuates the ROS load in post‐anoxic heart mitochondria. However, post‐ischaemic cardiac remodelling over 3 and 9 weeks was not improved. AOX blunted transcript levels of factors known to be up‐regulated upon I/R such as the atrial natriuretic peptide (Anp) whilst expression of pro‐fibrotic and pro‐apoptotic transcripts were increased. Ex vivo analysis revealed contractile failure at nine but not 3 weeks after ischaemia whilst label‐free quantitative proteomics identified an increase in proteins promoting adverse extracellular matrix remodelling. Together, this indicates an essential role for ETC‐derived signals during cardiac adaptive remodelling and identified ROS as a possible effector.

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Section: Aox Improves Mitochondrial Functions 3 Weeks After An Ischmentioning

confidence: 67%

Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia

Szibor

Schreckenberg

Gizatullina

et al. 2020

J Cellular Molecular Medi

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“…The developmental origins of health and disease (DOHaD) hypothesis describe the process by which environmental stimuli, including altered nutrition, during critical periods of development can program alterations in organogenesis, tissue development, and metabolism, predisposing the offspring to metabolic diseases during adulthood (5). Human and animal studies have demonstrated that exposure to overnutrition in early life may increase adiposity and insulin resistance in adulthood (6)(7)(8). Moreover, substantial evidence has indicated that dietary fatty acids, physical activity, or lower-calorie diets may change the susceptibility of metabolic diseases (9)(10)(11).…”

mentioning

confidence: 99%

Effects of postnatal overfeeding and fish oil diet on energy expenditure in rats

et al. 2017

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BackgroudEarly life nutrition may have a role in the regulation of metabolism in adulthood. The present study aimed to evaluate the effects of postnatal overfeeding and a postweaning fish oil diet on energy expenditure.MethodsOn postnatal day 3, rat litters were adjusted to a litter size of three (small litters, SLs) or ten (normal litters, NLs). After weaning, SLs were fed the standard diet or a fish oil diet enriched with polyunsaturated fatty acids (SL-FOs) for 10 weeks. The metabolic parameters of rats were monitored using the TSE LabMaster at postnatal week 3 (W) and postnatal week 13 (W).ResultsAt W, the O consumption and heat production in SLs were lower than those in NLs, while the respiratory exchange ratio (RER) was higher than NLs. SLs showed obesity, dyslipidemia, and impaired glucose tolerance at W. The postweaning fish oil diet in SLs not only increased O consumption, CO production, heat production, and reduced the RER but it also reduced weight gain, serum triglycerides, and improved glucose tolerance at W.ConclusionPostnatal overfeeding can decrease the level of body energy expenditure and induce obesity, but a fish oil diet can increase the energy expenditure and prevent the development of metabolic dysregulation in adults.

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“…The cardiovascular system is particularly sensitive to nutritional imbalances during lactation [18]. Studies on overfed pups in rodents have shown that overnutrition during lactation results in left ventricular cardiac hypertrophy and increased susceptibility to ischemia-reperfusion injury [20], impaired insulin signalling [21]* and leptin signalling [22], and leads to dysregulation of gene expression of cardiac structural proteins [23].…”

Section: Early Post-natal Life: Nutrition and Growthmentioning

confidence: 99%

Early nutrition, epigenetics, and cardiovascular disease

Loche

Ozanne²

2016

Current Opinion in Lipidology

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The burden of obesity and associated cardiometabolic diseases is believed to arise through interaction between an individual's genetics and the environment. Moreover, the risk of developing poor cardiometabolic health in adulthood is defined by early life exposure to pathological cues and can be inherited by future generations, initiating a vicious cycle of transmission of disease. Elucidating the molecular triggers of such a process will help tackle and prevent the uncontrolled rise in obesity and cardiometabolic disease.

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Overnutrition during lactation leads to impairment in insulin signaling, up-regulation of GLUT1 and increased mitochondrial carbohydrate oxidation in heart of weaned mice

Cited by 14 publications

References 51 publications

Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia

Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia

Effects of postnatal overfeeding and fish oil diet on energy expenditure in rats

Early nutrition, epigenetics, and cardiovascular disease

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