Overnight 5% Lidocaine Ointment for Treatment of Vulvar Vestibulitis

Partner Behavioral Responses to Pain Mediate the Relationship Between Partner Pain Cognitions and Pain Outcomes in Women With Provoked Vestibulodynia

“…Partner attributions about the women's pain were measured with the Extended Attributional Style Questionnaire 3,12,27,40 , adapted for use with partners of women experiencing pain during intercourse. The partner version has been used in a previous sample of PVD couples, but has not been properly validated 20 .…”

Randomized clinical trial of multimodal physiotherapy treatment compared to overnight lidocaine ointment in women with provoked vestibulodynia: Design and methods

“…However, when comparing lidocaine to other treatments, its efficacy was found nonsignificantly different than biofeedback in the study of Danielsson et al [27] and desipramine and/or placebo in the study of Foster et al [28]. The latter's posology and technique of application differed from those of Zolnoun et al [26], which may explain the lower efficacy. In fact, Danielsson et al [27] instructed women to apply lidocaine 2% and 5% five to seven times per day while Foster et al [28] recommended four-five daily applications of lidocaine 2% or 5% diluted in hydrating cream.…”

“…The primary aim is to compare the efficacy of multimodal PFM physiotherapy to overnight topical lidocaine for reducing pain during sexual intercourse in women with PVD. Considering the reported effectiveness of the two treatments [24], [25] and [26] and the opinion of experts, the main hypothesis is that, in comparison to lidocaine, women having physiotherapy will show a greater reduction of pain (post-treatment and at 6-month follow-up compared to baseline assessment). Secondary aims include comparing the effects of the two treatments on: 1) pain quality (affective, sensory and evaluative components); 2) sexual function; 3) psychological variables (catastrophizing, anxiety, depression, fear of pain); 4) PFM morphology and function and 5) patients' global impression of change.…”

“…The hypothesized mechanism of action is that repeated application of this anesthetic could act on nociceptor proliferation and sensitization [10]. Reducing their hyperexcitability is presumed to yield long-lasting pain reduction [10] and [26]. In a prospective uncontrolled study, Zolnoun et al [26] showed that overnight use of 5% lidocaine ointment applied for eight weeks significantly reduced pain and improved sexual function in 59% of participants with PVD.…”

“…Reducing their hyperexcitability is presumed to yield long-lasting pain reduction [10] and [26]. In a prospective uncontrolled study, Zolnoun et al [26] showed that overnight use of 5% lidocaine ointment applied for eight weeks significantly reduced pain and improved sexual function in 59% of participants with PVD. Other studies using lidocaine showed improvement in pain and sexual function.…”