Overly Exuberant Innate Immune Response to SARS-CoV-2 Infection

Zhou, Zhuo; Ren, Lili; Zhang, Li; Zhong, Jiaxin; Xiao, Yan; Jia, Zhilong; Guo, Li; Yang, Jing; Wang, Chun; Jiang, Shuai; Yang, Donghong; Zhang, Guoliang; Li, Hongru; Chen, Fuhui; Xu, Yufeng; Chen, Mingwei; Gao, Zhancheng; Yang, Jian; Dong, Jie; Liu, Bo; Zhang, Xiannian; Wang, Weidong; He, Kunlun; Jin, Qi; Li, Mingkun; Wang, Jianwei

doi:10.2139/ssrn.3551623

Cited by 57 publications

(57 citation statements)

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“…https://doi.org/10.1101/2020.04.19.20068015 doi: medRxiv preprint infected patients, as well as the transcripts of its receptor CCR2 and was associated with low circulating inflammatory monocytes (Figure 4I), suggesting a role for the CCL2/CCR2 axis in the monocyte chemoattraction into the inflamed lungs. These observations are in accordance with recently published studies in bronchoalveolar fluids from Covid-19 patients, describing the key role of monocytes 19 . Overall, these results support a framework whereby an ongoing inflammatory cascade, initiated by impaired type I IFN production, may be fueled by both PAMPs and DAMPs.…”

Section: (Which Was Not Certified By Peer Review)supporting

confidence: 93%

Impaired type I interferon activity and exacerbated inflammatory responses in severe Covid-19 patients

Hadjadj

Yatim

Barnabei

et al. 2020

Preprint

269

312

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Section: (Which Was Not Certified By Peer Review)supporting

confidence: 93%

Impaired type I interferon activity and exacerbated inflammatory responses in severe Covid-19 patients

Hadjadj

Yatim

Barnabei

et al. 2020

Preprint

269

312

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“…Bronchoalveolar fluid (BALF) from patients with severe COVID-19 was shown to be enriched in CCL2 and CCL7, two chemokines that are most potent at the recruitment of CC-chemokine receptor 2-positive (CCR2 + ) monocytes 23 . Accordingly, single-cell RNA sequencing (scRNA-seq) analysis of BALF collected from patients with severe or mild COVID-19 revealed increased proportions of MNPs, with these cells accounting for as much as 80% of total BALF cells in patients with severe COVID-19 compared with only approximately 60% and 40%, respectively, of total BALF cells in patients with mild disease or healthy controls 24 .…”

Section: Monocytes/macrophages In Covid-19mentioning

confidence: 99%

Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages

2020

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| The COVID-19 pandemic caused by infection with SARS-CoV-2 has led to more than 200,000 deaths worldwide. Several studies have now established that the hyperinflammatory response induced by SARS-CoV-2 is a major cause of disease severity and death in infected patients. Macrophages are a population of innate immune cells that sense and respond to microbial threats by producing inflammatory molecules that eliminate pathogens and promote tissue repair. However, a dysregulated macrophage response can be damaging to the host, as is seen in the macrophage activation syndrome induced by severe infections, including in infections with the related virus SARS-CoV. Here we describe the potentially pathological roles of macrophages during SARS-CoV-2 infection and discuss ongoing and prospective therapeutic strategies to modulate macrophage activation in patients with COVID-19. volume 20 | June 2020 | 361 nature reviews | ImmunOlOgy P r o g r e s s

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“…Severe acral ischemic lesions due to thrombosis have been observed in COVID-19 patients, usually admitted to intensive care units with very severe disease. 6 23 a link with chilblains has been hypothesized. 24 The acute and self-healing nature of COVID-19- The pathophysiology of acute idiopathic chilblains is unknown.…”

Section: Discussionmentioning

confidence: 99%

Chilblains in children in the setting of COVID‐19 pandemic

Andina

Noguera‐Morel

Bascuas-Arribas

et al. 2020

Pediatric Dermatology

191

328

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BackgroundDifferent skin manifestations of COVID‐19 are being reported. Acral lesions on the hands and feet, closely resembling chilblains, have been recognized during the peak incidence of the COVID‐19 pandemic.Material and methodsA retrospective review of 22 children and adolescents with chilblain‐like lesions seen over a short period of time in the Emergency Department of a children's hospital during the peak incidence of COVID‐19 in Madrid, Spain.ResultsAll patients had lesions clinically consistent with chilblains of the toes or feet, with three also having lesions of the fingers. Pruritus and mild pain were the only skin symptoms elicited, and only 10 had mild respiratory and/or GI symptoms. None had fever. Coagulation tests, hemogram, serum chemistry, and lupus anticoagulant were normal in all patients tested. One out of 16 tested cases had elevated D‐dimer results, but without systemic symptoms or other laboratory anomalies. SARS‐CoV‐2 PCR tested in 19 cases was positive in just one case. Skin biopsies obtained in six patients were consistent with chilblains. On follow‐up, all cases showed spontaneous marked improvement or complete healing.ConclusionAcute chilblains were observed during COVID‐19 pandemic in children and teenagers. It is a mildly symptomatic condition with an excellent prognosis, usually requiring no therapy. Etiopathogenesis remains unknown.

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Overly Exuberant Innate Immune Response to SARS-CoV-2 Infection

Cited by 57 publications

References 0 publications

Impaired type I interferon activity and exacerbated inflammatory responses in severe Covid-19 patients

Impaired type I interferon activity and exacerbated inflammatory responses in severe Covid-19 patients

Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages

Chilblains in children in the setting of COVID‐19 pandemic

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