Overlooked monkeypox cases among men having sex with men during the 2022 outbreak – a retrospective study

Feinsood, Anat Wieder; Zilberman, Tal; Erster, Oran; Kolasko, Gal Wagner; Biber, Asaf; Gophen, Ruth; Hoffman, Tomer; Litchevsky, Vladislav; Olmer, Liraz; Yahav, Dafna; Levy, Itzchak

doi:10.1016/j.ijid.2022.12.014

Cited by 12 publications

(21 citation statements)

References 9 publications

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“…In addition, we found that most patients were often misdiagnosed as folliculitis, mosquito bites, or skin allergies, especially when the rash initially appeared on the face and limbs. This differs from misdiagnosis trends observed in foreign, where patients were more commonly misdiagnosed with conditions such as bacterial tonsillitis, syphilis, or oral or genital herpes 41 . Several factors might contribute to these variations.…”

Section: Discussioncontrasting

confidence: 68%

“…This differs from misdiagnosis trends observed in foreign, where patients were more commonly misdiagnosed with conditions such as bacterial tonsillitis, syphilis, or oral or genital herpes. 41 Several factors might contribute to these variations. First, variances in the prevalence of diseases among different countries may influence doctors' diagnoses.…”

Section: Discussionmentioning

confidence: 99%

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Mpox patients' experience from infection to treatment and implications for prevention and control: A multicenter qualitative study in China

Zhang,

Qi,

Yang

et al. 2024

Journal of Medical Virology

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Monkeypox (mpox), a viral zoonotic disease, is spreading worldwide. However, evidence that informs prevention and control strategies in the Asia Pacific Region is very limited. Our study aims to investigate the experiences of mpox patients from infection to treatment to provide scientific basis for the prevention and control. A multicenter qualitative design was used. A total of 15 mpox patients were recruited between July 6 and July 25, 2023, from six cities in China. Semistructured interviews were conducted by telephone and analyzed using the thematic analysis. The interview was divided into two sections: patients' experiences (prediagnosis experience, treatment‐seeking experience, and quarantine experience) and advice. Prediagnosis experience was summarized into three themes: symptoms, possible routes of infection, and knowledge of mpox. Treatment‐seeking experience was summarized into three themes: time of visit to hospital, diagnostic difficulties, and attitude toward diagnosis. Quarantine experience was summarized into three themes: body and mind reactions, reluctance to self‐disclose infection status, and factors facilitating recovery. Themes identified from patients' advice were as follows: (1) Increase in testing channels and methods, (2) Development and introduction of vaccines, (3) Adjustment of quarantine program, (4) Improvement of treatment measures, and (5) Improvement of publicity and education. To effectively curb the mpox epidemic, structured measures are urgently needed to address the mpox‐related stigma and discrimination. Targeted health education should be provided to MSM, focusing on the prevention, detection, and treatment services. Hospitals should enhance the training of clinicians in key departments including infectious disease and dermatology, to improve diagnostic capability and sensitivity. Furthermore, given the absence of specific antiviral medications, supervised home quarantine may be a good option.

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Section: Discussioncontrasting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Mpox patients' experience from infection to treatment and implications for prevention and control: A multicenter qualitative study in China

Zhang,

Qi,

Yang

et al. 2024

Journal of Medical Virology

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“…reported in MSM with overlooked mpox infection, including cases that were primarily misdiagnosed as herpes. 11,12 Accordingly, both MPXV and HSV should be considered as pathogens causing oligosymptomatic proctitis.…”

Section: Proctitis Alone (Without Visible Lesions) Has Been Recentlymentioning

confidence: 99%

Anogenital herpes simplex virus infection clinically indistinguishable from mpox (formerly named monkeypox)

Kreuter

Müller

Schaller

et al. 2023

Journal of Medical Virology

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“…The MPX virus was first discovered in monkeys, but it also naturally infects tree squirrels, rope squirrels, Gambian pouched rats and dormice [ 4 ]. Several incidences of this novel endemic have been considered to be associated with sexual contact, particularly in bisexual or males [ 5 , 6 ]. Additionally, MPX can spread via body fluids, infected sores, scabs, and sharing of bedding and clothing [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Current Clinical Trials for the Monkeypox Virus

Kandeel

2023

Dr. Sulaiman Al Habib Med J

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Background Monkeypox (MPX) is a zoonotic Orthopoxvirus causing smallpox-like symptoms. Before April 2022, MPX cases outside Africa were rare. The virus can spread through skin-to-skin contact, sexual contact, respiratory droplets, and household items such as towels and blankets. Aim This study was aimed at highlighting the dire need for vaccination and treatment against this infection. Several in-process clinical trials that may help overcome MPX infection are discussed. Methods A search for recent clinical studies was conducted in the clinicaltrials.gov database. Results A total of 15 trials were identified. After February 2022, 14 new trials were launched. Of the 15 trials, 9 were observational studies, 3 were treatment studies and 3 were preventive studies. MPX clinical trial topics were classified into four broad categories: MPX virus shedding and clearance; response to MPX vaccine; antiviral treatment for MPX; and awareness regarding MPX. One medication, tecovirimat, and two vaccines are currently in clinical trials. Conclusions Few treatments and vaccines are under evaluation. Although multiple trials have been conducted, evidence to determine the present state of MPX infection is currently insufficient. Global collaboration is required to achieve complete understanding of the epidemiology, prevention and control of MPX.

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Overlooked monkeypox cases among men having sex with men during the 2022 outbreak – a retrospective study

Cited by 12 publications

References 9 publications

Mpox patients' experience from infection to treatment and implications for prevention and control: A multicenter qualitative study in China

Mpox patients' experience from infection to treatment and implications for prevention and control: A multicenter qualitative study in China

Anogenital herpes simplex virus infection clinically indistinguishable from mpox (formerly named monkeypox)

Current Clinical Trials for the Monkeypox Virus

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