Overlapping Cognitive Patterns in Schizophrenia and Methamphetamine Dependence

Salo, Ruth; Ravizza, Susan M.; Fassbender, Catherine

doi:10.1097/wnn.0b013e31823fc1d0

Cited by 15 publications

(8 citation statements)

References 66 publications

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“…The study of Jacobs et al (2008) revealed that patients with meth-induced psychotic disorder and those with paranoid schizophrenia have similar cognitive profiles. In contrast, Salo et al (2011) suggested that the cognitive functioning in meth users during the early stages of abstinence was worse than in patients with schizophrenia; furthermore, no correlation was found between their psychotic symptoms and task performance. However, previous studies have not considered the role of the duration of meth-induced psychosis on neurocognitive deficits.…”

Section: Introductionmentioning

confidence: 91%

“…The performance of METH + PP patients in most cognitive functioning domains was worse than that of their counterparts that did not experience persistent psychosis (METH − P and METH + BP) and the healthy control subjects. Several previous studies have reported that differentiating the clinical features of psychotic symptoms (Medhus et al, 2013;Srisurapanont et al, 2011) and cognitive profiles (Jacobs et al, 2008;Salo et al, 2011) between meth-related psychosis and schizophrenia can be challenging. Meth use may put users at a greater risk for developing psychotic symptoms.…”

Section: Cognitive Profiles Across Patient Groupsmentioning

confidence: 99%

“…Previous studies have linked the cognitive profiles of meth users with those of patients with schizophrenia (Jacobs et al, 2008;Salo et al, 2011). The study of Jacobs et al (2008) revealed that patients with meth-induced psychotic disorder and those with paranoid schizophrenia have similar cognitive profiles.…”

Section: Introductionmentioning

confidence: 99%

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Persistence of psychotic symptoms as an indicator of cognitive impairment in methamphetamine users

Chen

Lin

Chen

et al. 2015

Drug and Alcohol Dependence

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Section: Introductionmentioning

confidence: 91%

Section: Cognitive Profiles Across Patient Groupsmentioning

confidence: 99%

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Persistence of psychotic symptoms as an indicator of cognitive impairment in methamphetamine users

Chen

Lin

Chen

et al. 2015

Drug and Alcohol Dependence

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“…Despite similarities of the clinical manifestation between MAP and schizophrenia, few studies have addressed similarities and differences in the characteristics of prefrontal cortical dysfunction between the two disorders. A behavioral study reported that methamphetamine abusers in an early period of abstinence displayed greater attention deficits as indexed by Stroop interference effects than patients with schizophrenia (Salo, Ravizza & Fassbender ).…”

Section: Introductionmentioning

confidence: 99%

Characterizing prefrontal cortical activity during inhibition task in methamphetamine‐associated psychosis versus schizophrenia: a multi‐channel near‐infrared spectroscopy study

et al. 2015

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Methamphetamine abuse and dependence, frequently accompanied by schizophrenia-like psychotic symptoms [methamphetamine-associated psychosis (MAP)], is a serious public health problem worldwide. Few studies, however, have characterized brain dysfunction associated with MAP, nor investigated similarities and differences in brain dysfunction between MAP and schizophrenia. We compared prefrontal cortical activity associated with stop-signal inhibitory task in 21 patients with MAP, 14 patients with schizophrenia and 21 age- and gender-matched healthy controls using a 52-channel near-infrared spectroscopy (NIRS) system. Both the MAP and the schizophrenia groups showed significantly reduced activation in the bilateral ventrolateral prefrontal cortex compared with controls; however, only the MAP group showed reduced activation in the frontopolar prefrontal cortex. The MAP group demonstrated significant positive correlations between task performance and hemodynamic responses in the bilateral ventrolateral, polar and left dorsolateral regions of the prefrontal cortex. The MAP and schizophrenia groups demonstrated a significant difference in the relationship of impulsivity to hemodynamic changes in the bilateral premotor cortex. These findings characterize similarities and differences in prefrontal cortical dysfunction between psychosis associated with methamphetamine and schizophrenia. The reduced hemodynamic changes in the bilateral ventrolateral prefrontal cortex suggest a common underlying pathophysiology of MAP and schizophrenia, whereas those in the frontopolar prefrontal cortex point to an impaired state that is either inherent or caused specifically by methamphetamine use.

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“…Of note, it has been hypothesized that METH-induced changes in dopaminergic signaling involve a change in set point for drug reward that may represent an allostatic state contributing to vulnerability to relapse and re-entry into the addiction cycle (Koob 2000). It is, therefore, likely that the already observed dysfunction of prefrontal and limbic brain areas as well as fronto-striatal loops, which has repeatedly been reported in regular METH consumers (Chang et al 2007;Salo et al 2011;Bisagno et al 2016;Okada et al 2016), is also evident in their offspring. Given that cognitive functions mediated via the prefrontal cortex are highly predictive for school readiness, school success, job success, public safety, physical and mental health (Diamond 2013), it is likely that transgenerational effects are devastating for the upcoming generations and lead to strong societal problems.…”

mentioning

confidence: 93%

On the necessity of translational cognitive-neurotoxicological research in methamphetamine abuse and addiction

Stock

Beste

2017

Arch Toxicol

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high-risk behaviors, treatment non-adherence, and repeated relapses. This ultimately contributes to maintaining continuous drug-seeking behaviors (Cadet and Bisagno 2015), and thus indirectly enhances all of the toxicological effects of METH abuse. METH is often consumed for its effects which, among others, include increased energy levels and decreases in fatigue, increased psychomotor activity and alertness, anorectic effects, increases in sex drive, and euphoria. Yet, irritability, agitation, risky sexual behaviors, (motor) stereotypies, psychosis, seizures, hyperthermia and other systemic effects are also common acute (side) effects of METH consumption (Panenka et al. 2013;Cadet and Bisagno 2015;Chomchai and Chomchai 2015). Those effects are mainly attributed to increases in both central and peripheral monoaminergic signaling, with strong effects in the noradrenergic (NA) and dopaminergic (DA) systems (5-HT) (Schep et al. 2010;Carvalho et al. 2012). Repeated consumption causes striking and long-lasting dysfunctions in monoaminergic signaling which are characterized by decreases in the levels of monoamines and their metabolites, monoamine transporter-binding sites, lower expression and/or activity of enzymes involved in the synthesis and metabolism of brain monoamine neurotransmitters, and neurodegeneration (especially of dopaminergic nerve terminals) (Carvalho et al. 2012;Halpin et al. 2014). Other indirect acute neuronal effects of METH include the release of glutamate in cortical and subcortical regions as well as glia activation (Rocher and Gardier 2001;Carvalho et al. 2012).While these effects are well known, they have mostly been regarded to affect the consuming individual. In this regard, recent findings in animals by Fujaková-Lipski et al. (2017) have shown transgenerational effects of METH exposure by looking at how neurotoxic effects of METH administered in utero alter various neurotransmitter Keywords Addiction · Methamphetamine · Neurotoxicity · Translational Humans have been consuming stimulants like amphetamine in the form of cathinone (khat) for thousands of years, but since world war two, synthetic amphetamines, especially methamphetamine (METH), have hit many societies in a worldwide surge (Carvalho et al. 2012). Due to its highly addicting properties and the comparatively low cost, the abuse of this psychostimulant has rapidly increased in the last decades and years (Chomchai and Chomchai 2015) so that METH has become one of the most abused substances worldwide (Bernheim et al. 2016). Continued METH consumption does not only have devastating effects on the health and well-being of the addicted individuals, but also affects whole communities and put a considerable strain on healthcare systems (Panenka et al. 2013;Chomchai and Chomchai 2015). In addition, while all forms of METH toxicity are undoubtedly harmful to the affected individual, we think that it is worth to direct special attention to the neurotoxic effects and as the associated neurocognitive impairments (especially deficits in execu...

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Overlapping Cognitive Patterns in Schizophrenia and Methamphetamine Dependence

Cited by 15 publications

References 66 publications

Persistence of psychotic symptoms as an indicator of cognitive impairment in methamphetamine users

Persistence of psychotic symptoms as an indicator of cognitive impairment in methamphetamine users

Characterizing prefrontal cortical activity during inhibition task in methamphetamine‐associated psychosis versus schizophrenia: a multi‐channel near‐infrared spectroscopy study

On the necessity of translational cognitive-neurotoxicological research in methamphetamine abuse and addiction

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