Overlapping biologic exacerbation clusters in asthma and chronic obstructive pulmonary disease have distinct sputum mediator and microbiome profiles

Ghebre, Michael A; Pang, Pee Hwee; Diver, Sarah; Desai, Dhananjay; Bafadhel, Mona; Haldar, Koirobi; Kebadze, Tatiana; Cohen, Suzanne; Newbold, Paul; Rapley, Laura; Woods, Jennifer; Rugman, Paul; Pavord, Ian; Johnston, Sebastian L.; Barer, Michael R.; May, Richard; Brightling, Christopher

doi:10.1183/13993003.congress-2018.pa5468

Clinical Problems 2018

DOI: 10.1183/13993003.congress-2018.pa5468

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Overlapping biologic exacerbation clusters in asthma and chronic obstructive pulmonary disease have distinct sputum mediator and microbiome profiles

Michael A Ghebre¹,

Pee Hwee Pang²,

Sarah Diver³

et al.

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2024

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COPD Pathogenesis and Alterations in the Oral, Lung, and Gut Microbiomes

Asai,

Ohkuni,

Kato

et al. 2024

Microbiology Research

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Chronic obstructive pulmonary disease (COPD) is a respiratory and systemic disease affecting more than 300 million people globally every year, and it also becomes a substantial economic burden. COPD is commonly comorbid with various underlying diseases such as cancer, cardiovascular diseases, cerebrovascular diseases, diabetes mellitus, osteoporosis, etc. It has been shown that statins can improve a significant decline in pulmonary function among COPD patients due to their pleiomorphic effect. Some systematic reviews also reported that statins reduced the risk of COPD-related events such as cancer and cardiovascular events, eventually resulting in more favorable outcomes than for non-statin user COPD patients. However, the physiological mechanism is still elucidated. Recently, it has been reported that statins influence the gut microbial composition with increased relative abundance of Akkermansia muciniphila and Faecalibacterium prausnitzii and act with pleiomorphic effects such as anti-inflammatory and anti-cancer effects through modulating gut dysbiosis. We described this review to focus on whether statins can be a useful preventive option for COPD.

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COPD Pathogenesis and Alterations in the Oral, Lung, and Gut Microbiomes

Asai,

Ohkuni,

Kato

et al. 2024

Microbiology Research

View full text Add to dashboard Cite

show abstract

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Overlapping biologic exacerbation clusters in asthma and chronic obstructive pulmonary disease have distinct sputum mediator and microbiome profiles

Cited by 1 publication

References 0 publications

COPD Pathogenesis and Alterations in the Oral, Lung, and Gut Microbiomes

COPD Pathogenesis and Alterations in the Oral, Lung, and Gut Microbiomes

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