Overlap Syndrome of Asthma and COPD Predicts Low Quality of Life

Abstract

Patients with overlapping asthma and COPD differed from those patients with asthma or COPD only. Overlap syndrome was associated with low HRQoL.

Asthma‐COPD overlap syndrome—Coexistence of chronic obstructive pulmonary disease and asthma in elderly patients and parameters for their differentiation

“…showed prevalence of ACOS patients by gender increased depending on aging. Guidelines2, 4 showed the prevalence rates of ACOS have ranged between 15% and 55%,6, 7, 8 and concurrent doctor‐diagnosed asthma and COPD have been reported in between 15% and 20% of patients 9, 10, 11, 12. In Japan, Nagai et al 13.…”

“…They experience frequent exacerbations and have poor quality of life, a more decline in lung function and high mortality than asthma or COPD alone 5, 6. However, there was no generally agreed term or defining features for this category of chronic airway obstruction.…”

Mortality in Asthma-Chronic Obstructive Pulmonary Disease Overlap in the United States

“…407,409,413,414 However, there is no generally agreed term or defining features for this category of chronic airflow limitation, although a definition based upon consensus has been published for overlap in patients with existing COPD. 415 In spite of these uncertainties, there is broad agreement that patients with features of both asthma and COPD experience frequent exacerbations, 409 have poor quality of life, a more rapid decline in lung function and high mortality, 409,416 and consume a disproportionate amount of healthcare resources 417 than asthma or COPD alone. In these reports, the proportion of patients with features of both asthma and COPD is unclear and will have been influenced by the initial inclusion criteria used for the studies from which the data were drawn.…”

Current situation of asthma-COPD overlap syndrome (ACOS) in Chinese patients older than 40 years with airflow limitation: rationale and design for a multicenter, cross-sectional trial (study protocol)

“…Furthermore, lack of specific biomarkers for ACOS makes the diagnosis more difficult (5). Recurrent exacerbations, rapid disease progression, diminished health-related quality of life, rapidly deteriorating lung function, high co-morbidities, increased reversibility of airflow obstruction, eosinophilic bronchial and systemic inflammation, frequent hospitalization, and high mortality rates are frequently observed in such patients and they tend to receive an inconsistent healthcare management compared with either of the conditions alone (3)(4)(5)9,10). A stepwise approach for diagnosis and treatment of asthma, COPD, and ACOS is advised in the recent 2015 Global Initiative for Asthma (GINA) report along with differentiating features that identify and characterize ACOS (4).…”