Overlap connective tissue disease syndromes

Longitudinal Myelitis as a Rare First Symptom of Lupus in Overlap Syndrome

“…16 An immunological marker confirming the diagnosis of the SLE/SS overlap syndrome is the presence of anti-SS related antigen B antibody. 1 Given the prevalence of longitudinal myelitis in connective tissue diseases, SLE is the first to consider as a cause of this myelopathy. [4][5][6]12 Neuromyelitis optica has been considered in differential diagnosis.…”

“…Their simultaneous diagnosis is not necessary. 1 In the course of connective tissue diseases, one of the possible symptoms is an affection of the nervous system; and in a case of systemic lupus erythematosus (SLE), it leads to derivation of neuropsychiatric SLE as a variant of SLE with separate diagnostic criteria. One of its symptoms is myelitis, 2 usually affecting a single segment of the spine as transverse myelitis.…”

Inflammatory Myopathies with Cutaneous Involvement: from Diagnosis to Therapy

“…OS strictly predominates in females (male/ female ratio is 1:9), and usually associates with auto antibodies against anti-PM-Scl, U 1RNP and Ku antigens. 46 A distinct clinical variant is scleromyositis, an overlap of DM and systemic sclerosis.…”

Fatal Myocarditis in a Male with Systemic Sclerosis

“…Digital ulcers, joint manifestations, interstitial lung disease and gastrointestinal involvements are frequent manifestations. Cardiac manifestations are also observed [9]. Although considered as a disease serological marker, anti-PM-Scl antibody is not disease specific [9] and isn't positive in all cases.…”

“…Cardiac manifestations are also observed [9]. Although considered as a disease serological marker, anti-PM-Scl antibody is not disease specific [9] and isn't positive in all cases. In the study of Ranque et al concerning patients with myopathies related to systemic sclerosis, only 10% of patients have anti-PM-Scl antibodies [10].…”