Overlap between maculopapular exanthema and drug reaction with eosinophilia and systemic symptoms among cutaneous adverse drug reactions in a dermatology ward

Abstract

An overlapping pattern between MPE and DRESS was identified and characterized. There may be a continuum spectrum between MPE and DRESS.

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): An Interplay among Drugs, Viruses, and Immune System

“…The presence of facial edema is a characteristic presentation in DRESS syndrome, one which might be a predictor of a more serious reaction than drug-induced maculopapular exanthema (MPE) [15]. The mechanism underlying the development of facial edema is still unknown, but it may be related to the involvement of the vascular endothelial growth factor pathway [16].…”

Dysregulation of microRNA expression in the skin during cutaneous adverse drug reactions

“…The diagnosis of drug reaction with eosinophilia and systemic symptoms (DRESS), is challenging due to its heterogeneous clinical presentation and complex natural course 1 . It is therefore sometimes difficult, at an early stage, to differentiate between maculopapular exanthema (MPE) and DRESS due to overlapping clinical presentations 2,3 …”

“…1 It is therefore sometimes difficult, at an early stage, to differentiate between maculopapular exanthema (MPE) and DRESS due to overlapping clinical presentations. 2,3 To better characterize cutaneous adverse drug reactions (cADRs), several approaches have been proposed. MicroRNAs (miRNAs) are short noncoding RNA molecules usually composed of 18-25 nucleotides.…”

“…IFNγ and IL-17 conventional and Innate-like T-cell producers in adult asthmaTo the Editor, Compelling evidence outlined the importance of conventional T-helper (Th)2 and Th17 CD4 + T cells and of innate-like T cells (ILT), namely invariant natural killer T (iNKT), γδ T and mucosal-associated invariant T (MAIT) cells, as sources of inflammatory cytokines involved in asthma pathology [1][2][3][4][5]. Ideally, the analysis of the major inflammatory cells implicated in asthma severity should be performed in the airways.…”

Is DRESS syndrome a single entity or within a spectrum of adverse reactions to drug?

“…In the study by Pinto Gouveia et al . published in this issue of the BJD , the authors shed new light on drug‐induced MPE and DRESS.…”