Overlap Between Epilepsy and Neurodevelopmental Disorders: Insights from Clinical and Genetic Studies

Shimizu, H.; Morimoto, Yoshiro; Yamamoto, Naoki; Tayama, Tatsuyuki; Ozawa, Hiroki; Imamura, Akira

doi:10.36255/exon-publications-epilepsy-neurodevelopmental-disorders

Cited by 15 publications

(21 citation statements)

References 81 publications

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“…For instance, some chromosomal abnormalities, such as 5q14.3 and 7p22.3, were found in both ADHD and epilepsy [ 108 , 109 ]. Likewise, several single nucleotide polymorphisms (SNPs), including myocyte enhancer factor 2 (MEF2C)-related disorders and methyl-CpG binding protein 2 (MECP2), were also found to have a high rate in children with ADHD and CWE [ 110 ]. A growing body of genetic studies suggested a significant familial liability for epilepsy and comorbid ADHD in children with a history of maternal ADHD [ 99 ] and epilepsy [ 111 ], suggesting familial clusters of that ADHD and epilepsy.…”

Section: Adhd and Epilepsy: Mechanisms Of Associationmentioning

confidence: 99%

“…ADHD is a neurobiological disorder that encompasses several biological dimensions with multifactorial interactions. Thus, ADHD and epilepsy may share certain aspects of biological dimensions, despite the distinct clinical phenotypes [ 110 ]. Therefore, comprehensive omics data analysis is needed to investigate the biological overlap between ADHD and epilepsy.…”

Section: Adhd and Epilepsy: Mechanisms Of Associationmentioning

confidence: 99%

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Epilepsy and Attention Deficit Hyperactivity Disorder: Connection, Chance, and Challenges

Fan

Chiang

Chang

et al. 2023

IJMS

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Comorbidities are common in children with epilepsy, with nearly half of the patients having at least one comorbidity. Attention deficit hyperactivity disorder (ADHD) is a psychiatric disorder characterized by hyperactivity and inattentiveness level disproportional to the child’s developmental stage. The burden of ADHD in children with epilepsy is high and can adversely affect the patients’ clinical outcomes, psychosocial aspects, and quality of life. Several hypotheses were proposed to explain the high burden of ADHD in childhood epilepsy; the well-established bidirectional connection and shared genetic/non-genetic factors between epilepsy and comorbid ADHD largely rule out the possibility of a chance in this association. Stimulants are effective in children with comorbid ADHD, and the current body of evidence supports their safety within the approved dose. Nonetheless, safety data should be further studied in randomized, double-blinded, placebo-controlled trials. Comorbid ADHD is still under-recognized in clinical practice. Early identification and management of comorbid ADHD are crucial to optimize the prognosis and reduce the risk of adverse long-term neurodevelopmental outcomes. The identification of the shared genetic background of epilepsy and ADHD can open the gate for tailoring treatment options for these patients through precision medicine.

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Section: Adhd and Epilepsy: Mechanisms Of Associationmentioning

confidence: 99%

Section: Adhd and Epilepsy: Mechanisms Of Associationmentioning

confidence: 99%

Epilepsy and Attention Deficit Hyperactivity Disorder: Connection, Chance, and Challenges

Fan

Chiang

Chang

et al. 2023

IJMS

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“…In a systematic review and meta-analyses from 2015, estimates of ASD range from 11% for 22q11.2 deletion syndrome to 61% in females with RTT [34] . For all syndromes, odds ratios showed that people with ASD have a higher risk of genetic abnormalities than the general population.…”

Section: The Chronic Dynamic Systemic Encephalopathy Frameworkmentioning

confidence: 99%

The importance of genetics in an advanced integrative model of autism spectrum disorder

Ciolino¹,

Ferreira²,

Loyacono³

2022

J Transl Genet Genom

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Genes have long been considered to cause autism spectrum disorder (ASD). However, data obtained over the last 10 years indicate that the true role of genetics in ASD and the cost-benefit ratio of genetic testing following an ASD diagnosis warrant further investigation. ASD is heterogeneous with high individual complexity, and new findings related to systemic alterations in ASD (in addition to genetics) should be considered when attempting to optimize patient health. However, for some people with ASD and their families, genetic testing can identify genetic mutations or chromosomic alterations. This review mainly considers recent research (the last 5 years) on the role of genetic factors in ASD and the importance of genetic testing in a new Advanced Integrative Model of ASD.

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“…It is also suggested that in children with ADHD, epilepsy is three times more often than in the general population; thus it is assumed that ADHD and epilepsy are co-occurring conditions (e.g., Socanski et al, 2013). However, Shimizu et al (2022) believed that the background of epilepsy and neurodevelopmental conditions are biological and shared, which brings the question of the risk factors for epilepsy, such as seizures, epileptic status, and antiseizure therapy, have any imprint in ADHD emergence and if the development of the disorder in children with epilepsy can be prevented with satisfactory seizure control (Chidi et al, 2014; Drechsler et al, 2020; Shimizu et al, 2022). There is also a fact that children with recently diagnosed epilepsy at the early stages of the disease are 2.5 times more likely to develop ADHD symptoms than healthy controls (Besag et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…The International Classification of Diseases 11th Revision (ICD-11; World Health Organization [WHO], 2019) defines ADHD as a disorder with onset during the developmental period, typically early to mild childhood, with the same patterns of inattention and symptoms of hyperactivity/impulsivity. In addition, the ICD-11 clearly distinguishes between ADHD disorder and symptoms of inattention, hyperactivity, and impulsivity, which may be caused by the effects of drugs, including antiseizure medications (ASMs; Shimizu et al, 2022). In this regard, ASMs may lead to additional behavioral and attention problems (e.g., Davis et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Onset of Inattention and Hyperactivity in Children and Adolescents With Epilepsy 6 months After the Diagnosis

Rogač,

Stevanović,

Bečanović

et al. 2023

J Atten Disord

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Objective: Complete or major symptoms of ADHD are often present in epilepsy. This study evaluated inattention and hyperactivity symptoms over the first 6 months in newly diagnosed pediatric epilepsy without comorbid ADHD. Method: Children and adolescents with newly diagnosed epilepsy were followed for 6 months after starting antiseizure medications. The Nisonger Child Behavior Rating Form (NCBRF), Adverse Event Profile (AEP), and the Revised Wechsler Intelligence Scale for Children were used. Results: There was a marked increase in attention difficulties while a moderate increase in hyperactivity levels. AEP scores, changes in non-verbal aspects of intelligence, levels of hyperactivity at the follow-up, and attention at baseline were significant predictors for inattention. In contrast, only levels of hyperactivity at the baseline and inattention at the follow-up were significant predictors for hyperactivity. Conclusion: Significant inattention and hyperactivity levels originated 6 months after the diagnosis of epilepsy and starting antiseizure medication.

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Overlap Between Epilepsy and Neurodevelopmental Disorders: Insights from Clinical and Genetic Studies

Cited by 15 publications

References 81 publications

Epilepsy and Attention Deficit Hyperactivity Disorder: Connection, Chance, and Challenges

Epilepsy and Attention Deficit Hyperactivity Disorder: Connection, Chance, and Challenges

The importance of genetics in an advanced integrative model of autism spectrum disorder

Onset of Inattention and Hyperactivity in Children and Adolescents With Epilepsy 6 months After the Diagnosis

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