Background Walking and running are commonly used physical activities and rehabilitation therapies; they can effectively promote the neuromotor and cardiorespiratory functions [1-4]. Because of the convenience and controllability, treadmill exercise has become a common alternative to over-ground walking or running. It has been widely used in daily fitness, clinical rehabilitation, sport biomechanical research, and even astronaut training in space [5-7]. However, growing researches have reported the differences between