Overexpression of α1-protease Inhibitor and Galectin-1 in Radiation-induced Early Phase of Pulmonary Fibrosis

Im, Hee-Soon; Kim, Hyung Doo; Song, Jie‐Young; Han, Young‐Soo; Lee, Do-Youn; Kim, Chan-Wha; Yun, Yeon-Sook

doi:10.4143/crt.2006.38.2.92

Cited by 5 publications

(2 citation statements)

References 27 publications

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“…Using a proteomic approach, galectin-1, in combination with α1protease inhibitor, is reported to be overexpressed in the early phase of radiation-induced pulmonary fibrosis in a mouse model (Im et al, 2006). A profibrotic role of galectin-1 in the lungs has also been proposed by Kathiriya et al in a mouse model of pulmonary fibrosis acute exacerbations.…”

Section: Variables Statisticsmentioning

confidence: 87%

Elevated level of Galectin-1 in bronchoalveolar lavage of patients with idiopathic pulmonary fibrosis

Bennett

Bargagli

Bianchi

et al. 2020

Respiratory Physiology & Neurobiology

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Galectin-1 is a carbohydrate-binding protein involved in apoptosis, cell-proliferation and differentiation, implicated in T-cell homeostasis and survival. The aim of the present study was to determine concentrations of galectin-1 in BAL fluid from patients with IPF and other interstitial lung diseases in order to validate proteomic previous findings. Methods: 36 IPF patients (16 females, mean age of 64.8 ± 8.9 years), 24 sarcoidosis patients (15 females, mean age of 56.3 ± 13.4), 7 interstitial lung diseases associated to systemic sclerosis (ILD-SSc) patients (5 females, mean age of 55.5 ± 16.4) and six healthy controls (4 females, mean age 47.8 ± 15.2) were included. Galectin-1 concentrations were determined in BAL samples by an ELISA assay. Results: Galectin-1 concentrations were significantly higher in BAL of IPF patients than in sarcoidosis and ILD-SSc patients and healthy controls. In IPF patients, galectin-1 levels showed significant inverse correlations with DL CO %, K CO % and BAL lymphocyte percentages and a positive correlation with BAL macrophage percentages. Former IPF smokers had higher concentrations of this protein compared with non-smoker IPF patients. Conclusion: Galectin-1 was confirmed a protein of interest in idiopathic pulmonary fibrosis. Its BAL concentrations were higher in IPF patients than in controls and correlated with disease severity. Galectin-1 was suggested to have a role in the pathogenesis of IPF, principally through the ERK/MAPK pathway and the inhibition of galectin-1 is a potential therapeutic target worthy of research.

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Section: Variables Statisticsmentioning

confidence: 87%

Elevated level of Galectin-1 in bronchoalveolar lavage of patients with idiopathic pulmonary fibrosis

Bennett

Bargagli

Bianchi

et al. 2020

Respiratory Physiology & Neurobiology

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“…However, cancer patients also exhibit fibrosis and increased Gal-1 production during progression or chemotherapy [ 96 , 117 ]. Radiation-induced pulmonary fibrosis was observed to increase Gal-1 expression in a murine model [ 118 ]. Thus, these findings indicate that both the abnormal expression of Gal and cancer therapy result in fibrosis ( Figure 4 ).…”

Section: The Roles Of Galectins In Cancer Metabolism Reprogrammingmentioning

confidence: 99%

Galectins in Cancer and the Microenvironment: Functional Roles, Therapeutic Developments, and Perspectives

Chang

Chan

et al. 2021

Biomedicines

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Changes in cell growth and metabolism are affected by the surrounding environmental factors to adapt to the cell’s most appropriate growth model. However, abnormal cell metabolism is correlated with the occurrence of many diseases and is accompanied by changes in galectin (Gal) performance. Gals were found to be some of the master regulators of cell–cell interactions that reconstruct the microenvironment, and disordered expression of Gals is associated with multiple human metabolic-related diseases including cancer development. Cancer cells can interact with surrounding cells through Gals to create more suitable conditions that promote cancer cell aggressiveness. In this review, we organize the current understanding of Gals in a systematic way to dissect Gals’ effect on human disease, including how Gals’ dysregulated expression affects the tumor microenvironment’s metabolism and elucidating the mechanisms involved in Gal-mediated diseases. This information may shed light on a more precise understanding of how Gals regulate cell biology and facilitate the development of more effective therapeutic strategies for cancer treatment by targeting the Gal family.

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Tissue- and cell-specific localization of galectins, β-galactose-binding animal lectins, and their potential functions in health and disease

Nio‐Kobayashi

2016

Anat Sci Int

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Overexpression of α1-protease Inhibitor and Galectin-1 in Radiation-induced Early Phase of Pulmonary Fibrosis

Cited by 5 publications

References 27 publications

Elevated level of Galectin-1 in bronchoalveolar lavage of patients with idiopathic pulmonary fibrosis

Elevated level of Galectin-1 in bronchoalveolar lavage of patients with idiopathic pulmonary fibrosis

Galectins in Cancer and the Microenvironment: Functional Roles, Therapeutic Developments, and Perspectives

Tissue- and cell-specific localization of galectins, β-galactose-binding animal lectins, and their potential functions in health and disease

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