2012
DOI: 10.1016/j.bbrc.2012.08.147
|View full text |Cite
|
Sign up to set email alerts
|

Overexpression of ubiquitous mitochondrial creatine kinase (uMtCK) accelerates tumor growth by inhibiting apoptosis of breast cancer cells and is associated with a poor prognosis in breast cancer patients

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

3
43
0

Year Published

2013
2013
2022
2022

Publication Types

Select...
9
1

Relationship

0
10

Authors

Journals

citations
Cited by 34 publications
(46 citation statements)
references
References 24 publications
3
43
0
Order By: Relevance
“…The current model of mitochondrial interactosome (MI) considers the ATP synthasome and RC complexes together with voltage-dependent anion channel (VDAC) and mitochondrial creatine kinase (MtCK) as components of intracellular energetic units [22]. Even though MI is proven in striated muscles, the functional role of it, together with MtCK, in malignant samples remains controversial [78], but it indicates that both ATP synthasome and RC complexes can form even more complex functional structures.…”
Section: Resultsmentioning
confidence: 99%
“…The current model of mitochondrial interactosome (MI) considers the ATP synthasome and RC complexes together with voltage-dependent anion channel (VDAC) and mitochondrial creatine kinase (MtCK) as components of intracellular energetic units [22]. Even though MI is proven in striated muscles, the functional role of it, together with MtCK, in malignant samples remains controversial [78], but it indicates that both ATP synthasome and RC complexes can form even more complex functional structures.…”
Section: Resultsmentioning
confidence: 99%
“…PTTG1, F2RL1) as well as genes related to the transfer of high energy phosphate from mitochondria, potentially related to the failure to eliminate cancer cells via apoptosis (e.g. CKMT1A) [48, 49]. …”
Section: Discussionmentioning
confidence: 99%
“…Mitochondria are key organelles for energy production including glucose metabolism and oxidative phosphorylation with a critical role in cell survival and apoptosis. Amount and activity of mitochondria may hence play a critical role in tumor initiation and progression [4], and it is not surprising that mutations of mitochondrial genes or alterations of the mitochondrial content have been suggested to play an important role in various cancer types [5-8]. As a consequence, an increasing number of anti-cancer drugs is under development [9-11] targeting mitochondria and associated structures.…”
Section: Introductionmentioning
confidence: 99%