Overexpression of TRIB3 promotes angiogenesis in human gastric cancer

Dong, Shaoting; Xia, Jianbo; Wang, Hongqiang; Sun, Li; Wu, Zhenzhen; Bin, Jianping; Liao, Yulin; N, Li; Liao, Wangjun

doi:10.3892/or.2016.5017

Cited by 25 publications

(22 citation statements)

References 30 publications

(36 reference statements)

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“…NRP1 is also expected to be a therapeutic target for gastric cancer; the study of Zhang et al showed that the new tumor homing peptide iRGD could enhance the 5-FU chemotherapy effect on gastric cancer through NRP1 [ 28 ]. Dong et al believed that the overexpression of TRIB3 was related to tumor angiogenesis and poor prognosis in gastric cancer patients and TRIB3 was a promising molecular target for antiangiogenic therapy in gastric cancer [ 29 ]. Moreover, Wu et al proposed that the expression of TRIB3 could affect the apoptosis induced by the anticancer drug adriamycin, indicating that TRIB3 expression in response of anticancer drugs may reflect the therapeutic efficacy of gastric cancer [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Implications of Novel Gene Signatures in Gastric Cancer Microenvironment

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Prognostic Implications of Novel Gene Signatures in Gastric Cancer Microenvironment

et al. 2020

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“…A wealth of evidence has demonstrated that a wide variety of molecules such as miRNAs and genes are probably associated with EC 23–25. Remarkably, TRIB3 has recently been reported to be implicated in multiple cancers including tongue squamous cell carcinoma, gastric cancer, and breast cancer 18,26,27. In the present study, the findings revealed that TRIB3 expression levels were enhanced in endometrioid adenocarcinoma compared with the normal tissues, and TRIB3 could promote apoptosis and inhibit proliferation and colony formation of EC cells and possibly plays important roles in the AKT signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

<p>TRIB3 suppresses proliferation and invasion and promotes apoptosis of endometrial cancer cells by regulating the AKT signaling pathway</p>

Liu

et al. 2019

OTT

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Objective The aim of this study was to examine the effect of TRIB3 on proliferation, apoptosis, and migration of endometrial cancer (EC) cells and explore the relationship between TRIB3 and AKT signaling pathway in EC progression. Methods Immunohistochemical analysis was performed to measure the expression level of TRIB3 in normal endometrium tissues and EC tissues. Overexpression and shRNA knockdown techniques were applied by transfecting EC cells (ISK and AN3CA), and the effect of TRIB3 on EC cell biological behaviors was evaluated. Cell Counting Kit-8 and colony formation assays were utilized to investigate EC cell proliferation ability, and flow cytometry was performed to assess the apoptosis of EC cells. Moreover, the migration and invasion of EC cells were detected by transwell assay, and the levels of MMP-2 and MMP-9 were measured by ELISA. Additionally, Western blot analysis was carried out to determine the levels of AKT and p-AKT. Results The expression level of TRIB3 was higher in EC than normal endometrium tissues, and its overexpression promoted apoptosis and suppressed proliferation of EC cells. Furthermore, TRIB3 retarded the migration and invasion of EC cells and decreased the levels of MMP-2 and MMP-9. Conversely, TRIB3 inhibition enhanced the expression levels of MMP-2 and MMP-9, and proliferation and migration of EC cells but suppressed their apoptosis. Similarly, TRIB3 overexpression reduced while its knockdown increased the level of p-AKT. Conclusion TRIB3 inhibited proliferation and migration and promoted apoptosis of EC cells probably through regulating AKT signaling pathway.

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“…Higher expression of HMGA2 has been seen in breast, ovarian and colon cancer and pancreatic adenocarcinoma [22–25]. Overexpression of TRIB3 is associated with tumor angiogenesis and a poor prognosis in patients with gastric cancer [26], and patients with high TRIB3 expression were susceptible to a recurrence of the disease, and showed poorer overall survival than those with low expression [27].…”

Section: Discussionmentioning

confidence: 99%

Ectopic Otoconin 90 expression in triple negative breast cancer cell lines is associated with metastasis functions

Pearlman¹,

Rahman²,

Upadhyay³

et al. 2019

PLoS ONE

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Triple negative breast cancer (TNBC) is an aggressive tumor with propensity to metastasize and poor treatment options. Improving treatment options would be impactful; thus, finding a tumor-specific cell surface protein with metastasis promoting functions that could be knocked out was the goal of this study. The Otoconin 90 gene (OC90), frequently amplified in tumors on chromosome 8q24.22, was identified as a potential therapeutic candidate. Normally OC90 is expressed in the cochlea with no known function in other normal tissues. In silico analysis of The Cancer Genome Atlas (TCGA) multi-tumor RNAseq cohorts revealed that OC90 is expressed in many tumor types at high prevalence and genomic amplification is associated with the elevated mRNA expression. In vitro assays in TNBC cell lines revealed OC90 expression with control over cell viability, apoptosis and invasion. RNA-seq analysis of OC90-siRNA knockdown and OC90-overexpression in BT20, BT549, HCC38 cell lines identified co-expressed transcripts, HMGA2, POLE2 and TRIB3. Altered expression of HMGA2, POLE2 and TRIB3 was predictive of survival among members of the Metabric breast cancer cohort. Thus, OC90 represents a potential therapeutic target whose knockdown could improve the treatment of TNBC.

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Overexpression of TRIB3 promotes angiogenesis in human gastric cancer

Cited by 25 publications

References 30 publications

Prognostic Implications of Novel Gene Signatures in Gastric Cancer Microenvironment

Prognostic Implications of Novel Gene Signatures in Gastric Cancer Microenvironment

<p>TRIB3 suppresses proliferation and invasion and promotes apoptosis of endometrial cancer cells by regulating the AKT signaling pathway</p>

Ectopic Otoconin 90 expression in triple negative breast cancer cell lines is associated with metastasis functions

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